Nature - USA (2020-10-15)

3

nature research | reporting summary

October 2018

Animals and other organisms

Policy information about studies involving animals; ARRIVE guidelines recommended for reporting animal research

Laboratory animals All animals used in this study were of the species Mus musculus and the strain C57BL/6. Animals used for behavioral

experiments were males 2-3 months old (see methods).

Wild animals The study did not involve wild animals.

Field-collected samples The study did not involve samples collected from the field.

Ethics oversight Mice were maintained under standard conditions at the Goodman Cancer Research Centre (GCRC) animal facility, and all

experiments were carried out under the Canadian Council on Animal Care (CCAC) guidelines and were approved by both McGill

University and the University of Montréal (see methods).

Note that full information on the approval of the study protocol must also be provided in the manuscript.