Article
synthesis; Yilai Xu, G.P.K. and T.K. repeated key cellular biochemical experiments with both
DHHC7 and APT2; X.L. and M.Z. carried out the mouse experiments; M.Z. and H.L. drafted the
manuscript with inputs from all authors; X.Z. directed the patient study; M.E.L. provided all of
the DHHC plasmids and participated in data analysis; and H.L. directed the biochemical
studies. All authors read and approved the final manuscript.
Competing interests The authors declare no competing interests.
Additional information
Supplementary information is available for this paper at https://doi.org/10.1038/s41586-020-
2799-2.
Correspondence and requests for materials should be addressed to H.L.
Peer review information Nature thanks Bryan Dickinson, Marilyn Resh and the other,
anonymous, reviewer(s) for their contribution to the peer review of this work.
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