Nature - USA (2020-09-24)

Article

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Tracheal Nasopharyngeal Rectal BAL

CTRL

Hi D1

Lo D1

Hi D1 + AZTH

Lo D5

PrEP

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Days post infection

Vira

lload(

Log

copies / mL) 10

abcd

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Extended Data Fig. 2 | Viral loads of SARS-CoV-2-infected cynomolgus
macaques treated with HCQ. a–d, Viral loads measured by RT–qPCR in throat
swabs (a), nasal swabs (b), rectal swabs (c) and bronchoalveolar lavages (d). The
limit of detection was estimated at 2.3 log 10 copies of SARS-CoV-2 RNA per ml
and the limit of quantification was estimated at 3.9 log 10 copies per ml (dotted

horizontal line). Shaded zones indicate treatment periods. Baseline was

adjusted to day 0 on the graphs. CTRL, control; D1, treatment started on day 1;

D5, treatment started on day 5; Hi, high HCQ dose; Lo, low HCQ dose; PrEP,

pre-exposure prophylaxis.