Nature - USA (2020-09-24)

ND

ND

ND

BaselineDay 2Day 5Day 11/1 3

MF

3M

F1

MF

2

MF

5

MF

6

MF

4

MF

7

MF

8

CTRL

Baseline Day 2Day 5Day 11/13

MF

9

MF10

MF12

MF11

MF13

Hi D1

MF14

MF15

MF16

MF17

Baseline Day 2Day 5 Day 11/13

Lo D1

Baseline Day 2Day 5Day 11/13

MF18

MF19

MF20

MF21

MF22

Hi D1 + AZTH

MF23

MF24

MF25

MF26

Baseline Day 2 Day 5Day 11/13

Lo D5

MF27

MF28

MF29

MF30

MF31

PrEP

Baseline Day 2 Day 5

a

b

c

d

e

f

g

h

LesiNoonnetype Scor 0 e

Pleural GGthickenningO1 1

Crazy-paConsolidatioving pattern3n3

OperatorDateTimepoint^ Animal Localisation GGOthickenningPleural Crazy-papattervingn ConsolidationextensLesionion effuPleusionral scorTotal e

Cranialright lobe

Middle right lobe

Caudal right lobe

Cranialleftlobe culmen

Cranial left lobe lingula

Caudal left lobe

Accessory lobe

Pleural space

Total

LesionNoextensneionScore 0

25 < 25% < x < 50% of the of lobethe lobe^12

75 50 < x < < x < 100% 75% of of the the lobelobe^34

Pleural NoeffusneionScore 0

SlightMild (^12)
Severe 3
Extended Data Fig. 3 | Representative transversal slices of lung CT scans
from SARS-CoV-2-infected cynomolgus macaques treated with HCQ.
Imaging was performed at baseline and day 2, 5 and 11 or 13 post-exposure to
S A R S - C oV-2. a–f, Images are presented for each macaque according to their
group, with a window level of −300 and a window width of 1,600. g, h, CT
scoring scales (g) and example of the analysis worksheet (h). Total CT score is
the sum of all lung lobe scores including lesion type, extension contributions
and pleural effusion severity. ND, not determined.