Nature - USA (2020-09-24)

CTRL

Hi D1

Lo D1

Hi D1 + AZTH

Lo D5

PrEP

MF 1

MF 2

MF 3

MF 4

MF 5

MF 6

MF 7

MF 8

MF 9

MF 10

MF 11

MF 12

MF 13

MF 14

MF 15

MF16

MF17

MF18

MF19

MF20

MF21

MF22

MF23

MF24

MF25

MF26

MF27

MF28

MF29

MF30

MF31

WBC LymphocytesNeutrophils Monocytes

0

5

15

20

10

-8-4 02 4281216 0 428

0

5

15

20

10

-8-4 02 4281216 0 428

0

5

15

20

10

-8-4 02 4281216 0 428

0

5

15

20

10

-8-4 02 4281216 0 428

0

5

15

20

10

-8-4 02 4281216 0 428

0

5

15

20

10

-8-4 02 4281216 0 428

0

10

5

-8-4 02 4281216 0 428

0

10

5

-8-4 02 4281216 0 428

0

10

5

-8-4 02 42812160 428

0

10

5

-8-4 02 4281216 0 428

0

10

5

-8-4 02 4281216 0 428

0

10

5

-8-4 02 42812160 428

0

5

15

10

-8-4 02 42812160 428

0

5

15

10

-8-4 02 42812160 428

0

5

15

10

-8-4 02 4281216 0 428

0

5

15

10

-8-4 02 4281216 0 428

0

5

15

10

-8-4 02 4281216 0 428

0

5

15

10

-8-4 02 4281216 0 428

0.0

0.5

1.5

4.0

1.0

-8-4 024281216 0 428

3.0

0.0

0.5

1.5

4.0

1.0

-8-4 024281216 0 428

3.0

0.0

0.5

1.5

4.0

1.0

-8-4 024281216 0 428

3.0

0.0

0.5

1.5

4.0

1.0

-8-4 024281216 0 428

3.0

0.0

0.5

1.5

4.0

1.0

-8-4 024281216 0 428

3.0

0.0

0.5

1.5

4.0

1.0

-8-4 024281216 0 428

3.0

Days post infection

x 10

3 cells / μL

abcd

Extended Data Fig. 5 | Complete blood count of SARS-CoV-2-infected
cynomolgus macaques treated with HCQ. a–d, Absolute numbers of white
blood cells (WBC) (a), lymphocytes (b), neutrophils (c) and monocytes (d) in

SARS-CoV-2-infected macaques. Baseline was adjusted to day 0 on the graphs,

and to the first day of treatment (day 7 pre-exposure) for the PrEP group.

Shaded zones indicate treatment periods.