Article
Extended Data Fig. 6 | Cytokines and chemokines in the plasma of
SARS-CoV-2-exposed cynomolgus macaques treated with HCQ. a, b, Heat
maps of the plasmatic concentrations of 20 cytokines. Each column represents
one cytokine or chemokine; the colour scale (in pg ml−1) is shown at the bottom.
The asterisk indicates a significant difference in the concentration of TNF at
2 d.p.i. between the control group and the Hi D1 and/or Hi D1 + AZTH groups, as
shown in d. ‘X’ indicates that no measurement was determined for this time
point. c, d, Concentrations of IL-1R A and TNF at 2 d.p.i. Each plot represents one
macaque. Symbols represent mean of duplicate measurements for individual
macaques of two replicates for IL-1R A and a single replicate for TNF. Statistical
significance was determined using a two-sided Mann–Whitney U-test without
correction and P values are indicated on the graphs (c, d).