0
100
200
300
400
600
012461810 214 61820
MF1
MF2
MF3
MF4
MF5
MF6
MF7
MF8
0
100
200
300
400
600
012461810 214 61820
MF9
MF10
MF11
MF12
MF13
0
100
200
300
400
600
012461810 214 61820
MF14
MF15
MF16
MF17
0
100
200
300
400
600
012461810 214 61820
MF23
MF24
MF25
MF26
0
100
200
300
400
600
012461810 214 61820
MF 18
MF 19
MF 20
MF 21
MF 22
0
100
200
300
400
600
0246
Lo D5 Hi D1 + AZTH
CTRL Hi D1 Lo D1
MF 34
MF 35
MF 32
MF 33
MF 36
MF 37
PK Hi
PK Lo
PK Hi + AZTH
Days post infection
Days post infection
Days post treatment
IU / mL
abc
d e f
IU / mL
Extended Data Fig. 7 | Plasma ALT levels of cynomolgus macaques treated
with HCQ. In addition to the six SARS-CoV-2-infected groups, three groups of
two macaques were treated but not infected to follow HCQ pharmacokinetics.
a–f, ALT levels in the plasma are shown for all infected macaques (a–e) and the
uninfected, HCQ-treated macaques (f). Shaded zones indicate treatment
periods.