Nature - USA (2020-09-24)

Article

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ASAT
Albumin
Creatin
K
Creatinine
Haptoglobi
n
LDH
CRP
Total protein
g/Lm
g/LI
U/Lg
/L
mg/L
IU/L
g/LI
U/L
CTRL Hi D1
MF 1
MF 2
MF 3
MF 4
MF 5
MF 6
MF 7
MF 8
MF 9
MF 10
MF 11
MF 12
MF 13
Lo D1
MF 14
MF 15
MF 16
MF 17
Hi D1 + AZTH
MF 18
MF 19
MF 20
MF 21
MF 22
Lo D5
MF 23
MF 24
MF 25
MF 26
042 6
042 6
042 6
MF 34
MF 35
MF 32
MF 33
MF 36
MF 37
PK Hi
PK Lo
PK Hi

• AZTH
  PK
  abcfd e
  Days post infection post Days treatment
  042 6
  042 6
  042 6
  042 6
  042 6
  Extended Data Fig. 8 | Biochemistry analysis of cynomolgus macaques
  treated with HCQ. In addition to the six SARS-CoV-2-infected groups, three
  groups of two macaques were treated but not infected to follow HCQ
  pharmacokinetics. a–f, AST, albumin, creatine kinase, creatinine, haptoglobin,
  LDH, C-reactive protein (CRP) and total proteins levels were analysed in the
  plasma of all infected (a–e) and uninfected, treated (f) groups. Shaded zones
  indicate treatment periods.