Nature - USA (2020-09-24)

Extended Data Fig. 2 | Fluorescent microscope image of DNA-coated
compressed tetrahedral clusters. DNA strands are f luorescently labelled.
The image shows that the single-stranded DNA can be selectively
functionalized onto the TPM patches and that the polystyrene surfaces are
nearly bare. Note that the polystyrene surfaces need not be completely bare of
DNA strands: the areal coverage of DNA just has to be much lower on the
polystyrene surfaces than on the TPM patches, so that the DNA melting
temperatures for the sphere–patch or sphere–sphere interactions are lower
than for the patch–patch interaction. The melting temperatures for the
polystyrene–polystyrene and polystyrene–TPM interactions are always
6–20 °C below that of the TPM–TPM interaction. Inset, illustration of
DNA-coated compressed clusters: red, DNA-coated TPM patches; white,
polystyrene spheres not coated with DNA. Scale bar, 5 μm.