Extended Data Fig. 1 | Overview of radical side-chain installation and
relevant previous literature. a, Retrosynthetic analysis highlights the
chemoselective advantages of using carbon radical reagents paired with the
radical acceptor Dha (right) over the typical heterolytic 2e− reagents (left) for
the site-specific modification of proteins. b, c, Our previous work on radical
addition to Dha^14 ,^17 (b) and the mechanism highlighting unwanted side
reactions (red) (c). d, e, Summaries of previous works^24 ,^25 using photocatalysts
for ‘on-peptide’ radical generation for site-selective peptide modification,
highlighting their limitations and potential for undesired side reactions (red).