PART TWO: GETTING WELL AGAIN
◊ Bacterial phagocytosis by human neutrophils is de-
pressed by malonate.
◊ Malonate chelates calcium.
◊ Malonate drops the resting potential of muscle.
◊ Malonate causes air hunger (dyspnea).
◊ Methyl malonate is toxic to the kidney.
◊ Acetoacetyl Co A can transfer its Co A to malonic acid
to make malonyl Co A. This could lead to acetoacetate
buildup, namely ketonuria and possibly a block in fat
utilization of even numbered carbon atoms, leaving odd
numbered carbons to predominate.
◊ Malonic acid reacts with aldehydes.
◊ Thallium is chelated by malonic acid into a stable com-
pound. (This could explain accumulation effect in a tu-
mor.)
◊ A color test for malonates is tetra hydroquinoline-N-
propinal to form blue-violet compounds. It is sensitive to
0.01 mg malonate.
◊ Malonate complexes with zinc and magnesium, thereby
depleting them.
◊ A fall in malate concentration due to malonate causes
depletion of NADP.
◊ Malonate induces ketonemia.
◊ Malonate reduces oxygen uptake. Coenzyme Q10 is re-
quired to make ATP.
◊ Malonate raises cholesterol.
◊ D-malic acid complexes with malic dehydrogenase and
NADH, but is enzymatically inactive.
◊ Maleic acid is competitive inhibitor of succinic dehy-
drogenase.
◊ Synergism between rotenone and malonate occurs in
mitochondria.
◊ Malonate causes oxidation of NADH and cytochromes.
◊ Rats can convert malonate to acetate in the presence of
malonyl Co A.
◊ Malonate reduces survival of infected animals.
◊ Malonate fed to dogs is recovered as methyl malonate in
urine.
◊ Malonate can pick up an amino group from glutamine,
thereby destroying it.