specific length of time, the subjects
were asked to recreate that length of
time by pressing a key. Typically, with
longer time intervals, people under-
represent time (that is, hold the key
down for a shorter period of time than
reality). In the study, those who
received microdoses held the key
longer, better representing the actual
time interval.
Does this mean microdosing makes
you smarter? Terhune and his
co-authors were cautious in overint-
erpreting their finding. For one, it’s not
clear that perceiving time more
accurately is preferable. The brain
seems to favor underrepresenting
time for reasons that are unclear.
Disrupting the brain’s default way of
representing time, though, may
beneficial in certain daily tasks or
creative pursuits. That’s not clear yet,
and the relationship between time
perception and cognitive function
needs to be further developed.
Importantly, though, the finding does
show that microdoses changed brain
function in some way, despite not
inducing a strong drug “feeling.”
As Terhune and others start testing
the meatier microdosing claims with
rigorous methods, the era of psyche-
delic research that James Fadiman
had a hand in creating is closing.
Organizations that fund psychedelic
research are showing more interest in
testing microdoses alongside placebo
controls. One study, according to its
Web site, will test “the short-term
effects of various sizes of LSD
microdose on creativity, cognitive
flexibility and well-being” and “brain
activity, cognitive functions and mood”
over a four-week period.
So what’s riding on these studies?
For those who are already convinced
of microdosing’s powers, probably not
much. But quite a lot is at stake for
our broader understanding of the
brain and the potential for drugs—
LSD or otherwise—to enhance
cognitive abilities. Unlike large doses
of psychedelics, microdoses don’t
dissolve your ego. You don’t become
a better version of yourself by falling
apart and coming back together, like
the Saskatchewan alcoholics. Instead,
the mythology around microdosing
tells a different, and perhaps even
more compelling, story. Through
straightforward pharmacology,
microdoses may activate just the right
amount of receptors for us to be our
better selves.
—Sam RoseInfections and Drugs
to Treat Them Tied
to Eating Disorders
in Teens
A new study adds to growing evi-
dence that immune system dysfunc-
tion and altered gut microbes may
contribute to the development of
eating disordersWHEN Cynthia Bulik started studying
eating disorders back in the early
1980s, what she read in the scientific
literature clashed with what she saw
in the clinic. At the time, theories
about the causes of these conditions
were focused primarily on explana-
tions based on family dynamics and
sociocultural factors.
These descriptions could not
explain how, despite dangerously low
body weights, patients with eating
KATARZYNA BIALASIEWICZGETTY IMAGESNEWS