BNF for Children (BNFC) 2018-2019

Cyclophosphamide (as Cyclophosphamide monohydrate) 1 gramCyclophosphamide 1 g powder for solution for injection vials| 1 vialP£ ...

Ifosfamide 2 gramIfosfamide 2 g powder for concentrate for solution for injection vials| 1 vialP£ 228. 09 Melphalan lINDICATIONS ...

lMEDICINAL FORMS There can be variation in the licensing of different medicines containing the same drug. Forms available from s ...

SIDE-EFFECTS, FURTHER INFORMATIONCardiotoxicity is cumulative and may be irreversible, however responds to treatment if detected ...

Caelyx 20 mg/ 10 ml concentrate for solution for infusion vials| 1 vialP£ 360. 23 Powder for solution for injection ▶Doxorubin(m ...

lHEPATIC IMPAIRMENTUse with caution—consult local treatment protocol. lMONITORING REQUIREMENTS ▶Cardiac toxicityCardiac function ...

lMONITORING REQUIREMENTS ▶Haematological monitoringCytarabine is a potent myelosuppressant and requires careful haematological m ...

Mercaptopurine (6-Mercaptopurine) lINDICATIONS AND DOSE Severe ulcerative colitis|Severe Crohn’s disease ▶BY MOUTH ▶Child 2–17 y ...

Severe psoriasis unresponsive to conventional therapy (specialist use only) ▶BY MOUTH ▶Child 2–17 years:Initially 200 micrograms ...

thrombosis.fatigue.haemorrhage.hemiparesis. hypotension.increased risk of infection.infertility. leukoencephalopathy.malaise.men ...

▶Nordimet(Nordic Pharma Ltd) Methotrexate 25 mg per 1 mlNordimet 15 mg/ 0. 6 ml solution for injection pre-filled pens| 1 pre-fi ...

Pregnancy and reproductive functionin Cytotoxic drugs p. 531. lBREAST FEEDINGDiscontinue breast-feeding. lHEPATIC IMPAIRMENT Dos ...

ANTINEOPLASTIC DRUGS›PLATINUM COMPOUNDS Carboplatin 10-Jun-2016 lINDICATIONS AND DOSE Stage 4 neuroblastoma|Germ cell tumours|Lo ...

lMEDICINAL FORMS There can be variation in the licensing of different medicines containing the same drug. Solution for infusion ...

Raynaud’s phenomenon.reflexes absent.seizure. sensation abnormal.SIADH.skin reactions.stroke. thrombocytopenia.vertigo.vomiting ...

CAUTIONS, FURTHER INFORMATION ▶Hypersensitivity reactionsSerious hypersensitivity reactions, including life-threatening anaphyla ...

lMEDICINAL FORMS There can be variation in the licensing of different medicines containing the same drug. Powder for solution fo ...

lMONITORING REQUIREMENTS ▶Monitor plasma-mitotane concentration—consult product literature. lPRESCRIBING AND DISPENSING INFORMAT ...

Scottish Medicines Consortium (SMC) Decisions TheScottish Medicines Consortiumhas advised (October 2016 ) that pegaspargase (Onc ...

2.1 Cytotoxic drug-induced side effects DETOXIFYING DRUGS›UROPROTECTIVE DRUGS Mesna lINDICATIONS AND DOSE Urothelial toxicity fo ...