▶Grapefruit juiceis predicted to increase the exposure to
praziquantel.oStudy
▶H 2 receptor antagonists(cimetidine)moderately increase the
exposure topraziquantel.oStudy
▶HIV-protease inhibitorsare predicted to moderately increase
the exposure topraziquantel.nStudy
▶Idelalisibis predicted to moderately increase the exposure to
praziquantel.nStudy
▶Macrolides(clarithromycin)are predicted to moderately
increase the exposure topraziquantel.nStudy
▶Mitotaneis predicted to markedly decrease the exposure to
praziquantel. Avoid.oStudy
▶Rifampicinis predicted to markedly decrease the exposure to
praziquantel. Avoid.oStudy
Prazosin→see alpha blockers
Prednisolone→see corticosteroids
Prednisone→see corticosteroids
Pregabalin→see antiepileptics
Prilocaine→see anaesthetics, local
Primaquine→see antimalarials
Primidone→see antiepileptics
Procarbazine→seeTABLE 15p. 850 (myelosuppression),TABLE 13
p. 850 (serotonin syndrome)
FOOD AND LIFESTYLEProcarbazine is a mild monoamine-
oxidase inhibitor and might rarely interact with tyramine-rich
foods (such as mature cheese, salami, pickled herring,Bovril®,
Oxo®,Marmite®or any similar meat or yeast extract or
fermented soya bean extract, and some beers, lagers or
wines).
▶Alcohol (beverage)potentially causes a disulfiram-like
reaction when given withprocarbazine.oAnecdotal
▶Antiepileptics(carbamazepine, phenobarbital, phenytoin,
primidone)are predicted to increase the risk of
hypersensitivity reactions when given withprocarbazine.
rAnecdotal
▶Antiepileptics(fosphenytoin)are predicted to increase the risk
of hypersensitivity when given withprocarbazine.r
Anecdotal
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
procarbazine. Public Health England advises avoid (refer to
Green Book).rTheoretical
Prochlorperazine→see phenothiazines
Procyclidine→seeTABLE 10p. 849 (antimuscarinics)
▶SSRIs(paroxetine)slightly increase the exposure to
procyclidine. Monitor and adjust dose.oStudy
Proguanil→see antimalarials
Promazine→see phenothiazines
Promethazine→see antihistamines, sedating
Propafenone→see antiarrhythmics
Propantheline→seeTABLE 10p. 849 (antimuscarinics)
Propiverine→seeTABLE 10p. 849 (antimuscarinics)
▶Propiverineis predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.o
Theoretical
Propofol→seeTABLE 8p. 848 (hypotension),TABLE 11p. 849 (CNS
depressant effects)
▶Antiepileptics(valproate)potentially increase the
concentration ofpropofol. Adjust dose.rTheoretical
Propranolol→see beta blockers, non-selective
Propylthiouracil→seeTABLE 15p. 850 (myelosuppression)
▶Propylthiouracilis predicted to decrease the effects of
metyrapone. Avoid.oTheoretical
Proton pump inhibitors
esomeprazole.lansoprazole.omeprazole.pantoprazole.
rabeprazole..
▶Antifungals, azoles(voriconazole)increase the exposure to
proton pump inhibitors(esomeprazole, omeprazole). Adjust
dose.oStudy
▶Proton pump inhibitorsdecrease the absorption ofantifungals,
azoles(itraconazole). Administeritraconazolecapsules with an
acidic beverage.oStudy
▶Proton pump inhibitorsdecrease the absorption ofantifungals,
azoles(ketoconazole). Administerketoconazolewith an acidic
beverage.oStudy
▶Proton pump inhibitorsdecrease the absorption ofantifungals,
azoles(posaconazole)(oral suspension). Avoid.oStudy
▶Proton pump inhibitorsare predicted to decrease the
absorption ofbosutinib.oStudy
▶Proton pump inhibitorsare predicted to decrease the
absorption ofceritinib.oTheoretical
▶Esomeprazoleis predicted to increase the exposure to
cilostazol.oTheoretical
▶Omeprazoleis predicted to increase the exposure tocilostazol.
Adjustcilostazoldose.oStudy
▶Proton pump inhibitors(esomeprazole, omeprazole)potentially
increase the exposure toclobazam. Adjust dose.o
Theoretical
▶Proton pump inhibitors(esomeprazole, omeprazole)are
predicted to decrease the efficacy ofclopidogrel. Avoid.
oStudy
▶Proton pump inhibitorsare predicted to slightly to moderately
decrease the exposure todasatinib. Avoid.rStudy
▶Proton pump inhibitorsare predicted to decrease the
absorption ofdipyridamole(immediate release tablets).
oTheoretical
▶Proton pump inhibitorsare predicted to slightly decrease the
exposure toerlotinib. Avoid.oStudy
▶Proton pump inhibitorsare predicted to decrease the exposure
togefitinib.rTheoretical
▶HIV-protease inhibitors(tipranavir)decrease the exposure to
proton pump inhibitors. Avoid.rStudy
▶Proton pump inhibitorsdecrease the exposure toHIV-protease
inhibitors(atazanavir). Avoid or adjust dose.rStudy
▶Proton pump inhibitorsincrease the exposure toHIV-protease
inhibitors(saquinavir). Avoid.rStudy
▶Proton pump inhibitorsare predicted to decrease the exposure
toledipasvir. Adjust dose, seeledipasvir with sofosbuvirp. 401.
oTheoretical
▶Proton pump inhibitorsdecrease the clearance ofmethotrexate
(high-dose). Use with caution or avoid.rStudy
▶Proton pump inhibitorsare predicted to decrease the exposure
topazopanib. Avoid or administer concurrently without food.
oStudy
▶Proton pump inhibitorsare predicted to decrease the exposure
torilpivirine. Avoid.rStudy
▶Proton pump inhibitorspotentially decrease the exposure to
sofosbuvir. Adjust dose, seeledipasvir with sofosbuvirp. 401,
sofosbuvir with velpatasvir, and sofosbuvir with velpatasvir and
voxilaprevir.oStudy
▶Esomeprazoleis predicted to slightly to moderately increase
the exposure toSSRIs(citalopram, escitalopram). Monitor and
adjust dose.rTheoretical
▶Omeprazoleslightly to moderately increases the exposure to
SSRIs(citalopram, escitalopram). Monitor and adjust dose.
rStudy
▶Proton pump inhibitorsare predicted to decrease the
concentration ofvelpatasvir. Adjust dose, seesofosbuvir with
velpatasvir.oStudy
▶Proton pump inhibitorsare predicted to decrease the exposure
tovoxilaprevir. Adjust dose, seesofosbuvir with velpatasvir
and voxilaprevir.oStudy
Proxymetacaine→see anaesthetics, local
Pseudoephedrine→see sympathomimetics, vasoconstrictor
Pyrazinamide
▶Allopurinolis predicted to increase the risk of hyperuricaemia
when given withpyrazinamide.oTheoretical
▶Pyrazinamideis predicted to decrease the effects of
sulfinpyrazone.oTheoretical
Pyridostigmine→seeTABLE 6p. 848 (bradycardia),TABLE 20p. 851
(neuromuscular blocking effects)
▶Aminoglycosidesare predicted to decrease the effects of
pyridostigmine.oTheoretical→Also seeTABLE 20p. 851
Pyrimethamine→see antimalarials
Quetiapine→seeTABLE 8p. 848 (hypotension),TABLE 11p. 849 (CNS
depressant effects)
BNFC 2018 – 2019 Praziquantel—Quetiapine 977
Interactions
|Appendix 1
A1