Reboxetine
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toreboxetine.oAnecdotal
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure toreboxetine. Avoid.
oStudy
▶Antifungals, azoles(miconazole)are predicted to increase the
concentration ofreboxetine. Use with caution and adjust dose.
oTheoretical
▶Cobicistatis predicted to increase the exposure toreboxetine.
Avoid.oStudy
▶Enzalutamideis predicted to decrease the exposure to
reboxetine.oAnecdotal
▶HIV-protease inhibitorsare predicted to increase the exposure
toreboxetine. Avoid.oStudy
▶Idelalisibis predicted to increase the exposure toreboxetine.
Avoid.oStudy
▶Reboxetineis predicted to increase the risk of a hypertensive
crisis when given withlinezolid. Avoid.rTheoretical
▶Reboxetineis predicted to increase the risk of hypokalaemia
when given withloop diuretics.oTheoretical
▶Macrolides(clarithromycin)are predicted to increase the
exposure toreboxetine. Avoid.oStudy
▶Mitotaneis predicted to decrease the exposure toreboxetine.
oAnecdotal
▶Reboxetineis predicted to increase the risk of a hypertensive
crisis when given withmoclobemide. Avoid.rTheoretical
▶Reboxetineis predicted to increase the risk of a hypertensive
crisis when given withmonoamine-oxidase A and B inhibitors,
irreversible. Avoid.rTheoretical
▶Reboxetineis predicted to increase the risk of a hypertensive
crisis when given withmonoamine-oxidase B inhibitors
(rasagiline, selegiline). Avoid.rTheoretical
▶Rifampicinis predicted to decrease the exposure toreboxetine.
oAnecdotal
▶Reboxetineis predicted to increase the risk of hypokalaemia
when given withthiazide diuretics.oAnecdotal
Regorafenib→seeTABLE 15p. 850 (myelosuppression),TABLE 4p. 847
(antiplatelet effects)
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toregorafenib. Avoid.oStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure toregorafenib. Avoid.
oStudy
▶Cobicistatis predicted to increase the exposure toregorafenib.
Avoid.oStudy
▶Regorafenibis predicted to increase the risk of bleeding events
when given withcoumarins.rStudy
▶Enzalutamideis predicted to decrease the exposure to
regorafenib. Avoid.oStudy
▶Grapefruit juiceis predicted to increase the exposure to
regorafenib. Avoid.oTheoretical
▶HIV-protease inhibitorsare predicted to increase the exposure
toregorafenib. Avoid.oStudy
▶Idelalisibis predicted to increase the exposure toregorafenib.
Avoid.oStudy→Also seeTABLE 15p. 850
▶Macrolides(clarithromycin)are predicted to increase the
exposure toregorafenib. Avoid.oStudy
▶Regorafenibis predicted to increase the exposure to
methotrexate.rTheoretical→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure toregorafenib.
Avoid.oStudy→Also seeTABLE 15p. 850
▶Regorafenibis predicted to increase the exposure toNSAIDs
(mefenamic acid). Avoid.oTheoretical→Also seeTABLE 4
p. 847
▶Regorafenibis predicted to increase the risk of bleeding events
when given withphenindione.rTheoretical
▶Rifampicinis predicted to decrease the exposure to
regorafenib. Avoid.oStudy
▶Regorafenibis predicted to increase the exposure tostatins
(atorvastatin, fluvastatin, rosuvastatin).rTheoretical
Remifentanil→see opioids
Repaglinide→seeTABLE 14p. 850 (antidiabetic drugs)▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
torepaglinide. Monitor blood glucose and adjust dose.
oStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure torepaglinide.o
Study
▶Ciclosporinmoderately increases the exposure torepaglinide.
oStudy
▶Clopidogrelincreases the exposure torepaglinide. Avoid.
rStudy
▶Cobicistatis predicted to increase the exposure torepaglinide.
oStudy
▶Enzalutamideis predicted to decrease the exposure to
repaglinide. Monitor blood glucose and adjust dose.o
Study
▶Fibrates(gemfibrozil)increase the exposure torepaglinide.
Avoid.rStudy
▶HIV-protease inhibitorsare predicted to increase the exposure
torepaglinide.oStudy
▶Idelalisibis predicted to increase the exposure torepaglinide.
oStudy
▶Iron chelators(deferasirox)moderately increase the exposure
torepaglinide. Avoid.oStudy
▶Leflunomideis predicted to increase the exposure to
repaglinide.oStudy
▶Macrolides(clarithromycin)are predicted to increase the
exposure torepaglinide.oStudy
▶Mitotaneis predicted to decrease the exposure torepaglinide.
Monitor blood glucose and adjust dose.oStudy
▶Opicaponeis predicted to increase the exposure torepaglinide.
Avoid.oStudy
▶Pitolisantis predicted to decrease the exposure torepaglinide.
qTheoretical
▶Rifampicinis predicted to decrease the exposure to
repaglinide. Monitor blood glucose and adjust dose.o
Study
▶Teriflunomideis predicted to increase the exposure to
repaglinide.oStudy
▶Trimethoprimslightly increases the exposure torepaglinide.
Avoid or monitor blood glucose.oStudy
Retigabine→see antiepileptics
Retinoids→seeTABLE 5p. 847 (thromboembolism)
acitretin.adapalene.alitretinoin.bexarotene.isotretinoin.
tazarotene.tretinoin..▶Avoid concomitant use of keratolytics in patients taking
acitretinandisotretinoin.
▶Since systemic absorption can follow topical application of
isotretinoin, the possibility of interactions should be borne
in mind.
▶Alcohol (beverage)potentially increases the concentration of
acitretin. Avoid and for 2 months after stoppingacitretin,
p. 749.oStudy
▶Antiarrhythmics(amiodarone)are predicted to increase the
exposure toalitretinoin. Adjustalitretinoindose.o
Theoretical
▶Antifungals, azoles(fluconazole, itraconazole, ketoconazole,
miconazole, voriconazole)are predicted to increase the
exposure toalitretinoin. Adjustalitretinoindose.o
Theoretical
▶Antifungals, azoles(fluconazole, ketoconazole, voriconazole)are
predicted to increase the risk of tretinoin toxicity when given
withtretinoin.oStudy
▶Clopidogrelis predicted to increase the exposure to
alitretinoin. Adjustalitretinoindose.oTheoretical
▶Cobicistatis predicted to increase the exposure toalitretinoin.
Adjustalitretinoindose.oTheoretical
▶Fibrates(gemfibrozil)are predicted to increase the exposure to
alitretinoin. Adjustalitretinoindose.oTheoretical
▶Fibrates(gemfibrozil)increase the concentration of
bexarotene. Avoid.rStudy
▶HIV-protease inhibitorsare predicted to increase the exposure
toalitretinoin. Adjustalitretinoindose.oTheoretical980 Reboxetine—Retinoids BNFC 2018 – 2019
Interactions|Appendix 1A1