▶Rifampicinmoderately decreases the exposure tocabozantinib.
Avoid.oStudy
▶Rifampicinis predicted to moderately increase the clearance of
caffeine citrate. Monitor and adjust dose.oStudy
▶Rifampicinis predicted to decrease the exposure tocalcium
channel blockers(amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nimodipine). Monitor and adjust
dose.oStudy
▶Rifampicingreatly decreases the exposure tocalcium channel
blockers(diltiazem, verapamil).rStudy
▶Rifampicinmoderately decreases the exposure tocalcium
channel blockers(nifedipine). Avoid.rStudy
▶Rifampicinmoderately decreases the exposure tocanagliflozin.
Adjustcanagliflozindose.oStudy
▶Rifampicinis predicted to decrease the exposure tocannabis
extract. Avoid.rTheoretical
▶Rifampicindecreases the concentration ofcaspofungin. Adjust
caspofungindose,p. 372.oStudy
▶Rifampicinis predicted to decrease the exposure toceritinib.
Avoid.rStudy
▶Rifampicindecreases the concentration ofchloramphenicol.
oStudy
▶Rifampicinis predicted to decrease the exposure to
chlordiazepoxide.oTheoretical
▶Rifampicindecreases the concentration ofciclosporin.r
Study
▶Rifampicinis predicted to alter the effects ofcilostazol.
oTheoretical
▶Rifampicinis predicted to decrease the exposure tocinacalcet.
Monitor and adjust dose.oStudy
▶Rifampicindecreases the exposure toclomethiazole. Monitor
and adjust dose.oStudy
▶Rifampicindecreases the exposure toclozapine.r
Anecdotal
▶Rifampicinis predicted to decrease the exposure tocobicistat.
Avoid.rTheoretical
▶Rifampicinis predicted to decrease the exposure to
cobimetinib. Avoid.rTheoretical
▶Rifampicinis predicted to decrease the efficacy ofcombined
hormonal contraceptives. For FSRH guidance, see
Contraceptives, interactionsp. 497.rStudy
▶Rifampicinis predicted to decrease the exposure to
corticosteroids(budesonide, deflazacort, dexamethasone,
fludrocortisone, hydrocortisone, methylprednisolone,
prednisolone, prednisone, triamcinolone). Monitor and adjust
dose.oStudy
▶Rifampicinis predicted to decrease the exposure to
corticosteroids(fluticasone).qTheoretical
▶Rifampicindecreases the anticoagulant effect ofcoumarins.
rStudy
▶Rifampicinis predicted to markedly decrease the exposure to
crizotinib. Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure todabigatran.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure todabrafenib.
Avoid.oTheoretical
▶Rifampicinis predicted to moderately decrease the exposure
todaclatasvir. Avoid.rStudy
▶Rifampicindecreases the exposure todapsone.oStudy
▶Rifampicinis predicted to decrease the exposure to
darifenacin.oTheoretical
▶Rifampicinis predicted to decrease the exposure todasabuvir.
Avoid.rTheoretical
▶Rifampicinis predicted to markedly decrease the exposure to
dasatinib. Avoid.rStudy
▶Rifampicinis predicted to slightly decrease the exposure to
delamanid. Avoid.oStudy
▶Rifampicinis predicted to decrease the efficacy ofdesogestrel.
For FSRH guidance, seeContraceptives, interactionsp. 497.
rTheoretical
▶Rifampicinmoderately decreases the exposure todiazepam.
Avoid.oStudy
▶Rifampicindecreases the concentration ofdigoxin.o
Study
▶Rifampicindecreases the exposure todolutegravir. Adjust
dose.rStudy
▶Rifampicinis predicted to decrease the exposure toduloxetine.
oTheoretical
▶Rifampicinis predicted to decrease the exposure toedoxaban.
oStudy
▶Rifampicinslightly decreases the exposure toefavirenz. Adjust
dose.rStudy
▶Rifampicinis predicted to decrease the exposure toelbasvir.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure toeliglustat.
Avoid.rStudy
▶Rifampicinis predicted to increase the exposure to
eluxadoline. Avoid.oTheoretical
▶Rifampicinis predicted to decrease the concentration of
elvitegravir. Avoid.rTheoretical
▶Rifampicinis predicted to decrease the effects ofergotamine.
oTheoretical
▶Rifampicinis predicted to decrease the exposure toerlotinib.
Avoid or adjusterlotinibdose.rStudy
▶Rifampicinis predicted to decrease the efficacy ofetonogestrel.
For FSRH guidance, seeContraceptives, interactionsp. 497.
rTheoretical
▶Rifampicinis predicted to decrease the exposure toetravirine.
Avoid.rTheoretical
▶Rifampicinis predicted to decrease the concentration of
everolimus. Avoid or adjust dose.rStudy
▶Rifampicinmoderately decreases the exposure toexemestane.
oStudy
▶Rifampicinis predicted to decrease the exposure to
fesoterodine. Avoid.oStudy
▶Rifampicinis predicted to decrease the exposure tofingolimod.
oStudy
▶Rifampicinis predicted to decrease the exposure to
fosaprepitant. Avoid.oTheoretical
▶Rifampicinis predicted to decrease the exposure togefitinib.
Avoid.rStudy
▶Rifampicinmarkedly affects the exposure toglecaprevir.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure to
grazoprevir. Avoid.rStudy
▶Rifampicinis predicted to decrease the concentration of
guanfacine. Adjustguanfacinedose,p. 231.oStudy
▶Rifampicindecreases the concentration ofhaloperidol. Adjust
dose.oStudy
▶Rifampicinis predicted to moderately to markedly decrease
the exposure toHIV-protease inhibitors(atazanavir, darunavir,
fosamprenavir, lopinavir, saquinavir). Avoid.rStudy
▶Rifampicinslightly decreases the exposure toHIV-protease
inhibitors(ritonavir).rStudy
▶Rifampicinis predicted to decrease the exposure toHIV-
protease inhibitors(tipranavir). Avoid.rStudy
▶Rifampicinis predicted to decrease the effects ofhormone
replacement therapy.oAnecdotal
▶Rifampicinis predicted to decrease the exposure toibrutinib.
Avoid or adjustibrutinibdose.rStudy
▶Rifampicinis predicted to decrease the exposure toidelalisib.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure toimatinib.
Avoid.oStudy
▶Rifampicinis predicted to decrease the exposure toirinotecan.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure toiron
chelators(deferasirox). Monitor serum ferritin and adjust dose.
oStudy
▶Rifampicinis predicted to decrease the exposure toivabradine.
Adjust dose.oTheoretical
▶Rifampicinis predicted to moderately to markedly decrease
the exposure toivacaftor. Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure toixazomib.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure tolapatinib.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure toledipasvir.
Avoid.rTheoreticalBNFC 2018 – 2019 Rifampicin—Rifampicin 983
Interactions|Appendix 1A1