BNF for Children (BNFC) 2018-2019

▶Macrolides(clarithromycin)are predicted to increase the
exposure tozopiclone. Adjust dose.oTheoretical
▶Macrolides(erythromycin)are predicted to increase the
exposure tozopiclone. Adjust dose.oStudy
▶Mitotaneis predicted to decrease the exposure tozopiclone.
Adjust dose.oStudy
▶Netupitantis predicted to increase the exposure tozopiclone.
Adjust dose.oStudy
▶Nilotinibis predicted to increase the exposure tozopiclone.
Adjust dose.oStudy
▶Rifampicinis predicted to decrease the exposure tozopiclone.
Adjust dose.oStudy
Zuclopenthixol→seeTABLE 8p. 848 (hypotension),TABLE 9p. 849 (QT-
interval prolongation),TABLE 11p. 849 (CNS depressant effects)
▶Zuclopenthixolis predicted to decrease the effects ofdopamine
receptor agonists. Avoid.oTheoretical→Also seeTABLE 8
p. 848→Also seeTABLE 9p. 849
▶Zuclopenthixolis predicted to decrease the effects oflevodopa.
Avoid or monitor worsening parkinsonian symptoms.r
Theoretical→Also seeTABLE 8p. 848
▶Zuclopenthixolpotentially increases the risk of neurotoxicity
when given withlithium.rAnecdotal→Also seeTABLE 9
p. 849

BNFC 2018 – 2019 Zopiclone—Zuclopenthixol 1011

Interactions

|Appendix 1

A1