fractionation technique; it may also contain clotting
factors II, VII, and X.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Powder and solvent for solution for injection
▶AlphaNine(Grifols UK Ltd)
Factor IX high purity 1000 unitAlphaNine 1 , 000 unit powder and
solvent for solution for injection vials| 1 vialP£ 390. 00
Factor IX high purity 1500 unitAlphaNine 1 , 500 unit powder and
solvent for solution for injection vials| 1 vialPs
▶Haemonine(Biotest (UK) Ltd)
Factor IX high purity 500 unitHaemonine 500 unit powder and
solvent for solution for injection vials| 1 vialP£ 300. 00 (Hospital
only)
Factor IX high purity 1000 unitHaemonine 1 , 000 unit powder and
solvent for solution for injection vials| 1 vialP£ 600. 00 (Hospital
only)
▶Replenine-VF(Bio Products Laboratory Ltd)
Factor IX high purity 500 unitReplenine-VF 500 unit powder and
solvent for solution for injection vials| 1 vialP£ 180. 00
Factor IX high purity 1000 unitReplenine-VF 1 , 000 unit powder and
solvent for solution for injection vials| 1 vialP£ 360. 00
Powder and solvent for solution for infusion
▶BeneFIX(Pfizer Ltd)
Nonacog alfa 250 unitBeneFIX 250 unit powder and solvent for
solution for infusion vials| 1 vialP£ 151. 80 (Hospital only)
Nonacog alfa 500 unitBeneFIX 500 unit powder and solvent for
solution for infusion vials| 1 vialP£ 303. 60 (Hospital only)
Nonacog alfa 1000 unitBeneFIX 1 , 000 unit powder and solvent for
solution for infusion vials| 1 vialP£ 607. 20 (Hospital only)
Nonacog alfa 2000 unitBeneFIX 2 , 000 unit powder and solvent for
solution for infusion vials| 1 vialP£ 1 , 214. 40 (Hospital only)
Nonacog alfa 3000 unitBeneFIX 3 , 000 unit powder and solvent for
solution for infusion vials| 1 vialP£ 1 , 821. 60 (Hospital only)Factor XIII fraction, dried
(Human fibrin-stabilising factor, dried)
lINDICATIONS AND DOSE
Congenital factor XIII deficiency
▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION
▶Child:(consult haematologist)lCAUTIONSVaccination against hepatitis A and hepatitis B
may be required
lSIDE-EFFECTS
▶Rare or very rareAnaphylactoid reaction.dyspnoea.skin
reactionslMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Powder and solvent for solution for injection
▶Fibrogammin P(CSL Behring UK Ltd)
Factor XIII 250 unitFibrogammin 250 unit powder and solvent for
solution for injection vials| 1 vialP£ 106. 58
Factor XIII 1250 unitFibrogammin 1 , 250 unit powder and solvent for
solution for injection vials| 1 vialP£ 532. 90Fibrinogen, dried
(Human fibrinogen)
lINDICATIONS AND DOSE
Treatment of haemorrhage in congenital
hypofibrinogenaemia or afibrinogenaemia
▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION
▶Child:(consult haematologist)lCAUTIONSRisk of thrombosis
lSIDE-EFFECTS
▶Common or very commonFever.thromboembolism▶Frequency not knownChest pain.chills.cough.dyspnoea.
nausea.skin reactions.tachycardia.vomiting
lPREGNANCYManufacturer advises not known to be
harmful—no information available.
lBREAST FEEDINGManufacturer advises avoid—no
information available.
lPRESCRIBING AND DISPENSING INFORMATIONFibrinogen
is prepared from human plasma.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Powder for solution for infusion
▶Riastap(CSL Behring UK Ltd)
Fibrinogen 1 gramRiastap 1 g powder for solution for infusion vials
| 1 vialP£ 400. 00Protein C concentrate
lINDICATIONS AND DOSE
Congenital protein C deficiency
▶BY INTRAVENOUS INJECTION
▶Child:(consult haematologist)lCAUTIONSHypersensitivity to heparins.vaccination
against hepatitis A and hepatitis B may be required
lSIDE-EFFECTS
▶Rare or very rareDizziness.fever.skin reactions
▶Frequency not knownHaemothorax.hyperhidrosis.
restlessness
lPRESCRIBING AND DISPENSING INFORMATIONProtein C is
prepared from human plasma.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Powder and solvent for solution for injection
▶Ceprotin(Baxalta UK Ltd)
Protein C 500 unitCeprotin 500 unit powder and solvent for solution
for injection vials| 1 vialP£ 2 , 000. 00
Protein C 1000 unitCeprotin 1000 unit powder and solvent for
solution for injection vials| 1 vialP£ 1 , 000. 00BLOOD AND RELATED PRODUCTS›
HAEMOSTATIC PRODUCTSFactor VIII inhibitor bypassing
fraction
lINDICATIONS AND DOSE
Treatment and prophylaxis of haemorrhage in patients
with congenital factor VIII deficiency (haemophilia A)
and factor VIII inhibitors|Treatment of haemorrhage in
non-haemophiliac patients with acquired factor VIII
inhibitors
▶BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION
▶Child:(consult haematologist)lCONTRA-INDICATIONSDisseminated intravascular
coagulation
lCAUTIONSVaccination against hepatitis A and hepatitis B
may be required
lSIDE-EFFECTS
▶Common or very commonDizziness.headache.
hypersensitivity.hypotension.skin reactions
▶Frequency not knownAbdominal discomfort.anamnestic
reaction.angioedema.chest discomfort.chills.cough.
diarrhoea.disseminated intravascular coagulation.
drowsiness.dyspnoea.embolism and thrombosis.fever.
flushing.hypertension.ischaemic stroke.malaise.
myocardial infarction.nausea.paraesthesia.respiratory86 Bleeding disorders BNFC 2018 – 2019
Cardiovascular system2