eiiiiF 159Beclometasone dipropionate 04-Jan-2016
(Beclomethasone dipropionate)
lINDICATIONS AND DOSE
Prophylaxis of asthma
▶BY INHALATION OF POWDER
▶Child 5–11 years: 100 – 200 micrograms twice daily, dose
to be adjusted as necessary
▶Child 12–17 years: 200 – 400 micrograms twice daily;
increased if necessary up to 800 micrograms twice
daily, dose to be adjusted as necessary
CLENIL MODULITE®
Prophylaxis of asthma
▶BY INHALATION OF AEROSOL
▶Child 2–11 years: 100 – 200 micrograms twice daily
▶Child 12–17 years: 200 – 400 micrograms twice daily,
adjusted according to response; increased if necessary
up to 1 mg twice daily
QVAR®PREPARATIONS
Prophylaxis of asthma
▶BY INHALATION OF AEROSOL
▶Child 12–17 years: 50 – 200 micrograms twice daily;
increased if necessary up to 400 micrograms twice daily
POTENCY
▶Qvar®has extra-fine particles, is more potent than
traditional beclometasone dipropionate CFC-
containing inhalers and is approximately twice as
potent asClenil Modulite®.
DOSE EQUIVALENCE AND CONVERSION
▶Dose adjustments may be required for some inhaler
devices, see under individual preparations.lUNLICENSED USEEasyhaler®Beclometasone Dipropionate
is not licensed for use in children under 18 years.Clenil
Modulite®- 200 and - 250 are not licensed for use in
children under 12 years.IMPORTANT SAFETY INFORMATION
MHRA/CHM ADVICE (JULY 2008)
Beclometasone dipropionate CFC-free pressurised
metered-dose inhalers (Qvar®andClenil Modulite®)are
notinterchangeable and should be prescribed by brand
name;Qvar®has extra-fine particles, is more potent
than traditional beclometasone dipropionate CFC-
containing inhalers, and is approximately twice as
potent asClenil Modulite®.lINTERACTIONS→Appendix 1 : corticosteroids
lPRESCRIBING AND DISPENSING INFORMATIONThe MHRA
has advised (July 2008 ) that beclometasone dipropionate
CFC-free inhalers should be prescribed by brand name.
CLENIL MODULITE®Clenil Modulite®is not
interchangeable with other CFC-free beclometasone
dipropionate inhalers.
QVAR®PREPARATIONSWhen switching a patient with
well-controlled asthma from another corticosteroid
inhaler, initially a 100 -microgram metered dose ofQvar®
should be prescribed for 200 – 250 micrograms of
beclometasone dipropionate or budesonide and for
100 micrograms offluticasone propionate. When
switching a patient with poorly controlled asthma from
another corticosteroid inhaler, initially a 100 -microgram
metered dose ofQvar®should be prescribed for
100 micrograms of beclometasone dipropionate,
budesonide, orfluticasone propionate; the dose ofQvar®
should be adjusted according to response.
lPATIENT AND CARER ADVICESteroid card should be issued
with high doses of inhaled beclometasone dipropionate.Medicines for Children leaflet: Beclometasone for asthma
prevention (prophylaxis)www.medicinesforchildren.org.uk/
beclometasone-inhaler-asthma-prevention-prophylaxis- 0
lPROFESSION SPECIFIC INFORMATION
Dental practitioners’formulary
Clenil Modulite® 50 micrograms/metered inhalation may
be prescribed.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: cream, ointment
Inhalation powder
CAUTIONARY AND ADVISORY LABELS8, 10
▶Easyhaler (beclometasone)(Orion Pharma (UK) Ltd)
Beclometasone dipropionate 200 microgram per
1 doseEasyhaler Beclometasone 200 micrograms/dose dry powder
inhaler| 200 doseP£ 14. 93 DT = £ 14. 93
Pressurised inhalation
CAUTIONARY AND ADVISORY LABELS8, 10
▶Clenil Modulite(Chiesi Ltd)
Beclometasone dipropionate 50 microgram per 1 doseClenil
Modulite 50 micrograms/dose inhaler| 200 doseP£ 3. 70 DT =
£ 3. 70
Beclometasone dipropionate 100 microgram per 1 doseClenil
Modulite 100 micrograms/dose inhaler| 200 doseP£ 7. 42 DT =
£ 7. 42
Beclometasone dipropionate 200 microgram per 1 doseClenil
Modulite 200 micrograms/dose inhaler| 200 doseP£ 16. 17 DT =
£ 16. 17
Beclometasone dipropionate 250 microgram per 1 doseClenil
Modulite 250 micrograms/dose inhaler| 200 doseP£ 16. 29 DT =
£ 16. 29
▶Qvar(Teva UK Ltd)
Beclometasone dipropionate 50 microgram per 1 doseQvar 50
inhaler| 200 doseP£ 7. 87 DT = £ 3. 70
Beclometasone dipropionate 100 microgram per 1 doseQvar 100
inhaler| 200 doseP£ 17. 21 DT = £ 7. 42
▶Qvar Autohaler(Teva UK Ltd)
Beclometasone dipropionate 50 microgram per 1 doseQvar 50
Autohaler| 200 doseP£ 7. 87 DT = £ 7. 87
Beclometasone dipropionate 100 microgram per 1 doseQvar 100
Autohaler| 200 doseP£ 17. 21 DT = £ 17. 21
▶Qvar Easi-Breathe(Teva UK Ltd)
Beclometasone dipropionate 50 microgram per 1 doseQvar
50 micrograms/dose Easi-Breathe inhaler| 200 doseP£ 7. 74 DT =
£ 7. 87
Beclometasone dipropionate 100 microgram per 1 doseQvar
100 micrograms/dose Easi-Breathe inhaler| 200 doseP£ 16. 95
DT = £ 17. 21eiiiiF 159Budesonide 21-Dec-2017
lDRUG ACTIONBudesonide is a glucocorticoid, which exerts
significant local anti-inflammatory effects.lINDICATIONS AND DOSE
Bronchopulmonary dysplasia with spontaneous
respiration
▶BY INHALATION OF NEBULISED SUSPENSION
▶Neonate: 500 micrograms twice daily.▶Child 1–4 months: 500 micrograms twice daily
Bronchopulmonary dysplasia with spontaneous
respiration (severe symptoms)
▶BY INHALATION OF NEBULISED SUSPENSION
▶Child 1–4 months (body-weight 2.5 kg and above): 1 mg
twice daily
Prophylaxis of mild to moderate asthma (in patients
stabilised on twice daily dose)
▶BY INHALATION OF POWDER
▶Child 6–11 years: 200 – 400 micrograms once daily, dose
to be given in the evening160 Airways disease, obstructive BNFC 2018 – 2019
Respiratory system3