BNF for Children (BNFC) 2018-2019

(singke) #1
CAMCOLIT®MODIFIED-RELEASE TABLET

Treatment of mania|Treatment of bipolar disorder|
Treatment of recurrent depression|Treatment of
aggressive or self-harming behaviour
▶BY MOUTH
▶Child 12–17 years:Initially 1 – 1. 5 g daily, dose adjusted
according to serum-lithium concentration, doses are
initially divided throughout the day, but once daily
administration is preferred when serum-lithium
concentration stabilised
Prophylaxis of mania|Prophylaxis of bipolar disorder|
Prophylaxis of recurrent depression|Prophylaxis of
aggressive or self-harming behaviour
▶BY MOUTH
▶Child 12–17 years:Initially 300 – 400 mg daily, dose
adjusted according to serum-lithium concentration,
doses are initially divided throughout the day, but once
daily administration is preferred when serum-lithium
concentration stabilised
LISKONUM®
Treatment of mania|Treatment of bipolar disorder|
Treatment of recurrent depression|Treatment of
aggressive or self-harming behaviour
▶BY MOUTH
▶Child 12–17 years:Initially 225 – 675 mg twice daily, dose
adjusted according to serum-lithium concentration,
doses are initially divided throughout the day, but once
daily administration is preferred when serum-lithium
concentration stabilised
Prophylaxis of mania|Prophylaxis of bipolar disorder|
Prophylaxis of recurrent depression|Prophylaxis of
aggressive or self-harming behaviour
▶BY MOUTH
▶Child 12–17 years:Initially 225 – 450 mg twice daily, dose
adjusted according to serum-lithium concentration,
doses are initially divided throughout the day, but once
daily administration is preferred when serum-lithium
concentration stabilised

lUNLICENSED USENot licensed for aggressive or self-
harming behaviour. Not licensed for concomitant therapy
with antidepressant medication in children who have had
an incomplete response to treatment for acute depression
in bipolar disorder.Camcolit®brand not licensed for use in
children.
lINTERACTIONS→Appendix 1 : lithium

lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension
Modified-release tablet
CAUTIONARY AND ADVISORY LABELS10, 25
▶Lithium carbonate (Non-proprietary)
Lithium carbonate 400 mgLithium carbonate 400 mg modified-
release tablets| 100 tabletPsDT = £ 4. 02
▶Camcolit(Essential Pharma Ltd)
Lithium carbonate 400 mgCamcolit 400 modified-release tablets|
100 tabletP£ 48. 18 DT = £ 4. 02
▶Liskonum(Teofarma)
Lithium carbonate 450 mgLiskonum 450 mg modified-release
tablets| 60 tabletP£ 11. 84 DT = £ 11. 84
▶Priadel (lithium carbonate)(Sanofi)
Lithium carbonate 200 mgPriadel 200 mg modified-release tablets
| 100 tabletP£ 2. 76 DT = £ 2. 76
Lithium carbonate 400 mgPriadel 400 mg modified-release tablets
| 100 tabletP£ 4. 02 DT = £ 4. 02
Tablet
CAUTIONARY AND ADVISORY LABELS 10
▶Lithium carbonate (Non-proprietary)
Lithium carbonate 250 mgLithium carbonate 250 mg tablets|
100 tabletP£ 87. 00 DT = £ 87. 00

eiiiiF 232

Lithium citrate


lINDICATIONS AND DOSE
Treatment and prophylaxis of mania|Treatment and
prophylaxis of bipolar disorder|Treatment and
prophylaxis of recurrent depression|Treatment and
prophylaxis of aggressive or self-harming behaviour
▶BY MOUTH
▶Child:Dose adjusted according to serum-lithium
concentration; doses are initially divided throughout
the day, but once daily administration is preferred
when serum-lithium concentration stabilised
DOSE EQUIVALENCE AND CONVERSION
▶Preparations vary widely in bioavailability;
changing the preparation requires the same
precautions as initiation of treatment.
LI-LIQUID®
Treatment and prophylaxis of mania|Treatment and
prophylaxis of bipolar disorder|Treatment and
prophylaxis of recurrent depression|Treatment and
prophylaxis of aggressive or self-harming behaviour
▶BY MOUTH
▶Child:Dose adjusted according to serum-lithium
concentration
DOSE EQUIVALENCE AND CONVERSION
▶ForLi-Liquid®: lithium citrate tetrahydrate 509 mg is
equivalent to lithium carbonate 200 mg.
PRIADEL®LIQUID
Treatment and prophylaxis of mania|Treatment and
prophylaxis of bipolar disorder|Treatment and
prophylaxis of recurrent depression|Treatment and
prophylaxis of aggressive or self-harming behaviour
▶BY MOUTH
▶Child:Dose adjusted according to serum-lithium
concentration, doses are initially divided throughout
the day, but once daily administration is preferred
when serum-lithium concentration stabilised
DOSE EQUIVALENCE AND CONVERSION
▶ForPriadel®liquid: lithium citrate tetrahydrate 520 mg
is equivalent to lithium carbonate 204 mg.

lUNLICENSED USENot licensed for use in children.
lINTERACTIONS→Appendix 1 : lithium

lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Oral solution
CAUTIONARY AND ADVISORY LABELS 10
▶Lithium citrate (Non-proprietary)
Lithium citrate 101.8 mg per 1 mlLithium citrate 509 mg/ 5 ml oral
solution| 150 mlPsDT = £ 5. 79
Lithium citrate 104 mg per 1 mlLithium citrate 520 mg/ 5 ml oral
solution sugar free sugar-free| 150 mlPs
Lithium citrate 203.6 mg per 1 mlLithium citrate 1. 018 g/ 5 ml oral
solution| 150 mlPsDT = £ 11. 58
▶Li-Liquid(Rosemont Pharmaceuticals Ltd)
Lithium citrate 101.8 mg per 1 mlLi-Liquid 509 mg/ 5 ml oral
solution| 150 mlP£ 5. 79 DT = £ 5. 79
Lithium citrate 203.6 mg per 1 mlLi-Liquid 1. 018 g/ 5 ml oral
solution| 150 mlP£ 11. 58 DT = £ 11. 58
▶Priadel (lithium citrate)(Sanofi)
Lithium citrate 104 mg per 1 mlPriadel 520 mg/ 5 ml liquid sugar-
free| 150 mlP£ 6. 73

234 Mental health disorders BNFC 2018 – 2019


Nervous system

4

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