▶Rare or very rareRespiratory disorders.trismus
▶Frequency not knownAngioedema.extrasystole.
hypersensitivity vasculitis.hypoglycaemia.pancytopenia
.parkinsonism.rhabdomyolysis.severe cutaneous
adverse reactions (SCARs).SIADH.thrombocytopenia
SIDE-EFFECTS, FURTHER INFORMATIONHaloperiol is a less
sedating antipsychotic.
lPREGNANCYManufacturer advises it is preferable to
avoid—moderate amount of data indicate no malformative
or fetal/neonatal toxicity, however there are isolated case
reports of birth defects following fetal exposure, mostly in
combination with other drugs; reproductive toxicity
shown inanimalstudies.
lHEPATIC IMPAIRMENTManufacturer advises use with
caution.
Dose adjustmentsManufacturer advises halve initial dose
and then adjust if necessary with smaller increments and
at longer intervals.
lRENAL IMPAIRMENTManufacturer advises use with
caution.
Dose adjustmentsManufacturer advises consider lower
initial dose in severe impairment and then adjust if
necessary with smaller increments and at longer intervals.
lMONITORING REQUIREMENTS
▶Manufacturer advises monitor electrolytes before
treatment initiation and periodically during treatment.
▶Manufacturer advises perform ECG before treatment
initiation and assess need for further ECGs during
treatment on an individual basis.
lPRESCRIBING AND DISPENSING INFORMATION
Palliative careFor further information on the use of
haloperidol in palliative care, seewww.palliativedrugs.com/
formulary/en/haloperidol.html.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension, oral solution
Tablet
CAUTIONARY AND ADVISORY LABELS 2
▶Haloperidol (Non-proprietary)
Haloperidol 500 microgramHaloperidol 500 microgram tablets|
28 tabletP£ 22. 05 DT = £ 22. 05
Haloperidol 1.5 mgHaloperidol 1. 5 mg tablets| 28 tabletP
£ 15. 00 DT = £ 12. 91
Haloperidol 5 mgHaloperidol 5 mg tablets| 28 tabletP£ 18. 00
DT = £ 14. 95
Haloperidol 10 mgHaloperidol 10 mg tablets| 28 tabletP
£ 27. 00 DT = £ 22. 25
Solution for injection
▶Haloperidol (Non-proprietary)
Haloperidol 5 mg per 1 mlHaloperidol 5 mg/ 1 ml solution for
injection ampoules| 10 ampouleP£ 35. 00 DT = £ 35. 00
Oral solution
CAUTIONARY AND ADVISORY LABELS 2
▶Haloperidol (Non-proprietary)
Haloperidol 1 mg per 1 mlHaloperidol 5 mg/ 5 ml oral solution sugar
free sugar-free| 100 mlP£ 35. 99 DT = £ 6. 47 sugar-free|
500 mlP£ 32. 35
Haloperidol 2 mg per 1 mlHaloperidol 10 mg/ 5 ml oral solution
sugar free sugar-free| 100 mlP£ 46. 75 DT = £ 7. 10 sugar-free|
500 mlP£ 35. 50
▶Haldol(Janssen-Cilag Ltd)
Haloperidol 2 mg per 1 mlHaldol 2 mg/ml oral solution sugar-free|
100 mlP£ 4. 45 DT = £ 7. 10
Capsule
CAUTIONARY AND ADVISORY LABELS 2
▶Serenace(Teva UK Ltd)
Haloperidol 500 microgramSerenace 500 microgram capsules|
30 capsuleP£ 1. 18 DT = £ 1. 18eiiiiF 244Pericyazine
(Periciazine)
lINDICATIONS AND DOSE
Schizophrenia (under expert supervision)|Psychoses
(severe mental or behavioural disorders only) (under
expert supervision)
▶BY MOUTH
▶Child 1–11 years:Initially 500 micrograms daily for 10 -kg
child, increased by 1 mg for each additional 5 kg; dose
may be gradually increased according to response but
maintenance should not exceed twice initial dose;
maximum 10 mg per day
▶Child 12–17 years:Initially 25 mg 3 times a day,
increased in steps of 25 mg every week, adjusted
according to response, increased if necessary up to
100 mg 3 times a day, total daily dose may alternatively
be given in^2 divided doseslUNLICENSED USETablets not licensed for use in children.
lCONTRA-INDICATIONSCNS depression.comatose states.
phaeochromocytoma
lCAUTIONSHypothyroidism
lINTERACTIONS→Appendix 1 : phenothiazines
lSIDE-EFFECTSAtrioventricular block.cardiac arrest.
consciousness impaired.contact dermatitis.glucose
tolerance impaired.hepatic disorders.hyperthermia.
nasal congestion.postural hypotension.priapism.
respiratory depression
lHEPATIC IMPAIRMENTCan precipitate coma;
phenothiazines are hepatotoxic.
lRENAL IMPAIRMENTAvoid in renal impairment.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension, oral solution
Oral solution
CAUTIONARY AND ADVISORY LABELS 2
▶Pericyazine (Non-proprietary)
Pericyazine 2 mg per 1 mlPericyazine 10 mg/ 5 ml oral solution|
100 mlP£ 55. 20 DT = £ 55. 20
Tablet
CAUTIONARY AND ADVISORY LABELS 2
▶Pericyazine (Non-proprietary)
Pericyazine 2.5 mgPericyazine 2. 5 mg tablets| 84 tabletP
£ 18. 60 DT = £ 18. 60
Pericyazine 10 mgPericyazine 10 mg tablets| 84 tabletP
£ 48. 00 DT = £ 48. 00eiiiiF 244Perphenazine
lINDICATIONS AND DOSE
Schizophrenia and other psychoses|Mania|Short-term
adjunctive management of anxiety|Severe psychomotor
agitation, excitement, and violent or dangerously
impulsive behaviour|Severe nausea and vomiting
unresponsive to other anti-emetics
▶BY MOUTH
▶Child 14–17 years (under close medical supervision):
Initially 4 mg 3 times a day, adjusted according to
response; maximum 24 mg per daylCONTRA-INDICATIONSCNS depression.comatose states.
phaeochromocytoma
lCAUTIONSHypothyroidism
lINTERACTIONS→Appendix 1 : phenothiazines
lSIDE-EFFECTSCardiac arrest.consciousness impaired.
ejaculation impaired.epilepsy.eye deposits.fatigue.246 Mental health disorders BNFC 2018 – 2019
Nervous system4