lDIRECTIONS FOR ADMINISTRATIONOlanzapine
orodispersible tablet may be placed on the tongue and
allowed to dissolve, or dispersed in water, orange juice,
apple juice, milk, or coffee.
lPATIENT AND CARER ADVICEPatients or carers should be
given advice on how to administer orodispersible tablets.
Medicines for Children leaflet: Olanzapine for schizophrenia,
bipolar disorder, mania and agitationwww.medicinesforchildren.
org.uk/olanzapine-schizophrenia-bipolar-disorder-mania-and-
agitationlMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension, oral solution
Tablet
CAUTIONARY AND ADVISORY LABELS 2
▶Olanzapine (Non-proprietary)
Olanzapine 2.5 mgOlanzapine 2. 5 mg tablets| 28 tabletP
£ 21. 85 DT = £ 5. 03
Olanzapine 5 mgOlanzapine 5 mg tablets| 28 tabletP£ 43. 70
DT = £ 10. 72
Olanzapine 7.5 mgOlanzapine 7. 5 mg tablets| 28 tabletP
£ 62. 27 DT = £ 29. 71 | 56 tabletP£ 12. 10 – £ 131. 10
Olanzapine 10 mgOlanzapine 10 mg tablets| 28 tabletP£ 87. 40
DT = £ 18. 98
Olanzapine 15 mgOlanzapine 15 mg tablets| 28 tabletP
£ 119. 18 DT = £ 24. 58
Olanzapine 20 mgOlanzapine 20 mg tablets| 28 tabletP
£ 158. 90 DT = £ 36. 83
▶Zalasta(Consilient Health Ltd)
Olanzapine 2.5 mgZalasta 2. 5 mg tablets| 28 tabletP£ 18. 57
DT = £ 5. 03
Olanzapine 5 mgZalasta 5 mg tablets| 28 tabletP£ 37. 14 DT =
£ 10. 72
Olanzapine 7.5 mgZalasta 7. 5 mg tablets| 56 tabletP£ 111. 43
Olanzapine 10 mgZalasta 10 mg tablets| 28 tabletP£ 74. 29 DT
=£ 18. 98
Olanzapine 15 mgZalasta 15 mg tablets| 28 tabletP£ 101. 30
DT = £ 24. 58
Olanzapine 20 mgZalasta 20 mg tablets| 28 tabletP£ 135. 06
DT = £ 36. 83
▶Zyprexa(Eli Lilly and Company Ltd)
Olanzapine 2.5 mgZyprexa 2. 5 mg tablets| 28 tabletP£ 21. 85
DT = £ 5. 03
Olanzapine 5 mgZyprexa 5 mg tablets| 28 tabletP£ 43. 70 DT =
£ 10. 72
Olanzapine 7.5 mgZyprexa 7. 5 mg tablets| 56 tabletP£ 131. 10
Olanzapine 10 mgZyprexa 10 mg tablets| 28 tabletP£ 87. 40 DT
=£ 18. 98
Olanzapine 15 mgZyprexa 15 mg tablets| 28 tabletP£ 119. 18
DT = £ 24. 58
Olanzapine 20 mgZyprexa 20 mg tablets| 28 tabletP£ 158. 90
DT = £ 36. 83
Oral lyophilisate
▶Zyprexa(Eli Lilly and Company Ltd)
Olanzapine 5 mgZyprexa 5 mg Velotabs sugar-free| 28 tabletP
£ 48. 07 DT = £ 48. 07
Olanzapine 10 mgZyprexa 10 mg Velotabs sugar-free|
28 tabletP£ 87. 40 DT = £ 87. 40
Olanzapine 15 mgZyprexa 15 mg Velotabs sugar-free|
28 tabletP£ 131. 10 DT = £ 131. 10
Olanzapine 20 mgZyprexa 20 mg Velotabs sugar-free|
28 tabletP£ 174. 79 DT = £ 174. 79
Orodispersible tablet
CAUTIONARY AND ADVISORY LABELS 2
EXCIPIENTS:May contain Aspartame
▶Olanzapine (Non-proprietary)
Olanzapine 5 mgOlanzapine 5 mg orodispersible tablets sugar free
sugar-free| 28 tabletP£ 15. 27 – £ 27. 03 DT = £ 21. 53
Olanzapine 5 mg orodispersible tablets| 28 tabletP£ 30. 00 DT =
£ 25. 63
Olanzapine 10 mgOlanzapine 10 mg orodispersible tablets|
28 tabletP£ 50. 00 DT = £ 43. 25
Olanzapine 10 mg orodispersible tablets sugar free sugar-free|
28 tabletP£ 27. 37 – £ 49. 74 DT = £ 34. 53
Olanzapine 15 mgOlanzapine 15 mg orodispersible tablets sugar free
sugar-free| 28 tabletP£ 30. 86 – £ 66. 76 DT = £ 36. 60Olanzapine 15 mg orodispersible tablets| 28 tabletP£ 50. 00 DT =
£ 44. 33
Olanzapine 20 mgOlanzapine 20 mg orodispersible tablets sugar
free sugar-free| 28 tabletP£ 47. 19 – £ 96. 14 DT = £ 78. 52
Olanzapine 20 mg orodispersible tablets| 28 tabletP£ 80. 00 DT =
£ 70. 23
▶Zalasta(Consilient Health Ltd)
Olanzapine 5 mgZalasta 5 mg orodispersible tablets sugar-free|
28 tabletP£ 40. 85 DT = £ 21. 53
Olanzapine 10 mgZalasta 10 mg orodispersible tablets sugar-free|
28 tabletP£ 74. 29 DT = £ 34. 53
Olanzapine 15 mgZalasta 15 mg orodispersible tablets sugar-free|
28 tabletP£ 111. 43 DT = £ 36. 60
Olanzapine 20 mgZalasta 20 mg orodispersible tablets sugar-free|
28 tabletP£ 148. 57 DT = £ 78. 52
eiiiiF 244Quetiapine
lDRUG ACTIONQuetiapine is a dopamine D 1 , dopamine D 2 ,
5 -HT 2 , alpha 1 -adrenoceptor, and histamine- 1 receptor
antagonist.lINDICATIONS AND DOSE
Schizophrenia
▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES
▶Child 12–17 years (under expert supervision):Initially
25 mg twice daily, adjusted according to response.
adjusted in steps of 25 – 50 mg; maximum 750 mg per
day
▶BY MOUTH USING MODIFIED-RELEASE MEDICINES
▶Child 12–17 years (under expert supervision):Initially
50 mg once daily, adjusted according to response.
adjusted in steps of 50 mg daily, usual dose
400 – 800 mg once daily; maximum 800 mg per day
Treatment of mania in bipolar disorder
▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES
▶Child 12–17 years (under expert supervision): 25 mg twice
daily for day 1 , then 50 mg twice daily for day 2 , then
100 mg twice daily for day 3 , then 150 mg twice daily
for day 4 , then 200 mg twice daily for day 5 , then
adjusted in steps of up to 100 mg daily, adjusted
according to response, usual dose 400 – 600 mg daily in
2 divided doses
DOSE EQUIVALENCE AND CONVERSION
▶Patients can be switched from immediate-release to
modified-release tablets at the equivalent daily dose;
to maintain clinical response, dose titration may be
required.lUNLICENSED USENot licensed for use in children.
lCAUTIONSCerebrovascular disease.patients at risk of
aspiration pneumonia.treatment of depression in patients
under 25 years (increased risk of suicide)
lINTERACTIONS→Appendix 1 : quetiapine
lSIDE-EFFECTS
▶Common or very commonAppetite increased.asthenia.
dysarthria.dyspepsia.dyspnoea.fever.headache.
irritability.palpitations.peripheral oedema.postural
hypotension.rhinitis.sleep disorders.suicidal behaviour
(particularly on initiation).suicidal ideation (particularly
on initiation).syncope.vision blurred.vomiting.
withdrawal syndrome
▶UncommonAnaemia.bradycardia.diabetes mellitus.
dysphagia.hyponatraemia.hypothyroidism.sexual
dysfunction.skin reactions.thrombocytopenia
▶Rare or very rareAngioedema.breast swelling.
gastrointestinal disorders.hepatic disorders.hypothermia
.menstrual disorder.metabolic syndrome.pancreatitis.
rhabdomyolysis.severe cutaneous adverse reactions
(SCARs).SIADH
lPREGNANCYUse only if potential benefit outweighs risk.
lBREAST FEEDINGManufacturer advises avoid.252 Mental health disorders BNFC 2018 – 2019
Nervous system4