BNF for Children (BNFC) 2018-2019

lHEPATIC IMPAIRMENT
Dose adjustmentsForimmediate-release tablets, initially
25 mg daily, increased daily in steps of 25 – 50 mg.
Formodified-release tablets, initially^50 mg daily,
increased daily in steps of 50 mg.

lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension, oral solution, powder
Modified-release tablet
CAUTIONARY AND ADVISORY LABELS2, 23, 25
▶Atrolak XL(Accord Healthcare Ltd)
Quetiapine (as Quetiapine fumarate) 50 mgAtrolak XL 50 mg
tablets| 60 tabletP£ 67. 65 DT = £ 67. 66
Quetiapine (as Quetiapine fumarate) 150 mgAtrolak XL 150 mg
tablets| 60 tabletP£ 107. 45 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 200 mgAtrolak XL 200 mg
tablets| 60 tabletP£ 113. 10 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 300 mgAtrolak XL 300 mg
tablets| 60 tabletP£ 169. 99 DT = £ 170. 00
Quetiapine (as Quetiapine fumarate) 400 mgAtrolak XL 400 mg
tablets| 60 tabletP£ 226. 19 DT = £ 226. 20
▶Biquelle XL(Aspire Pharma Ltd)
Quetiapine (as Quetiapine fumarate) 50 mgBiquelle XL 50 mg
tablets| 60 tabletP£ 29. 45 DT = £ 67. 66
Quetiapine (as Quetiapine fumarate) 150 mgBiquelle XL 150 mg
tablets| 60 tabletP£ 49. 45 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 200 mgBiquelle XL 200 mg
tablets| 60 tabletP£ 49. 45 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 300 mgBiquelle XL 300 mg
tablets| 60 tabletP£ 74. 45 DT = £ 170. 00
Quetiapine (as Quetiapine fumarate) 400 mgBiquelle XL 400 mg
tablets| 60 tabletP£ 98. 95 DT = £ 226. 20
▶Brancico XL(Zentiva)
Quetiapine (as Quetiapine fumarate) 50 mgBrancico XL 50 mg
tablets| 60 tabletP£ 12. 00 DT = £ 67. 66
Quetiapine (as Quetiapine fumarate) 150 mgBrancico XL 150 mg
tablets| 60 tabletP£ 26. 00 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 200 mgBrancico XL 200 mg
tablets| 60 tabletP£ 26. 00 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 300 mgBrancico XL 300 mg
tablets| 60 tabletP£ 45. 00 DT = £ 170. 00
Quetiapine (as Quetiapine fumarate) 400 mgBrancico XL 400 mg
tablets| 60 tabletP£ 60. 00 DT = £ 226. 20
▶Mintreleq XL(Aristo Pharma Ltd)
Quetiapine (as Quetiapine fumarate) 50 mgMintreleq XL 50 mg
tablets| 60 tabletP£ 14. 99 DT = £ 67. 66
Quetiapine (as Quetiapine fumarate) 150 mgMintreleq XL 150 mg
tablets| 60 tabletP£ 29. 99 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 200 mgMintreleq XL 200 mg
tablets| 60 tabletP£ 29. 99 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 300 mgMintreleq XL 300 mg
tablets| 60 tabletP£ 49. 99 DT = £ 170. 00
Quetiapine (as Quetiapine fumarate) 400 mgMintreleq XL 400 mg
tablets| 60 tabletP£ 64. 99 DT = £ 226. 20
▶Seroquel XL(AstraZeneca UK Ltd)
Quetiapine (as Quetiapine fumarate) 50 mgSeroquel XL 50 mg
tablets| 60 tabletP£ 67. 66 DT = £ 67. 66
Quetiapine (as Quetiapine fumarate) 150 mgSeroquel XL 150 mg
tablets| 60 tabletP£ 113. 10 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 200 mgSeroquel XL 200 mg
tablets| 60 tabletP£ 113. 10 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 300 mgSeroquel XL 300 mg
tablets| 60 tabletP£ 170. 00 DT = £ 170. 00
Quetiapine (as Quetiapine fumarate) 400 mgSeroquel XL 400 mg
tablets| 60 tabletP£ 226. 20 DT = £ 226. 20
▶Sondate XL(Teva UK Ltd)
Quetiapine (as Quetiapine fumarate) 50 mgSondate XL 50 mg
tablets| 60 tabletP£ 14. 98 DT = £ 67. 66
Quetiapine (as Quetiapine fumarate) 150 mgSondate XL 150 mg
tablets| 60 tabletP£ 29. 98 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 200 mgSondate XL 200 mg
tablets| 60 tabletP£ 29. 98 DT = £ 113. 10
Quetiapine (as Quetiapine fumarate) 300 mgSondate XL 300 mg
tablets| 60 tabletP£ 49. 98 DT = £ 170. 00
Quetiapine (as Quetiapine fumarate) 400 mgSondate XL 400 mg
tablets| 60 tabletP£ 64. 98 DT = £ 226. 20

▶Zaluron XL(Fontus Health Ltd)

Quetiapine (as Quetiapine fumarate) 50 mgZaluron XL 50 mg

tablets| 60 tabletP£ 27. 96 DT = £ 67. 66

Quetiapine (as Quetiapine fumarate) 150 mgZaluron XL 150 mg

tablets| 60 tabletP£ 46. 96 DT = £ 113. 10

Quetiapine (as Quetiapine fumarate) 200 mgZaluron XL 200 mg

tablets| 60 tabletP£ 46. 96 DT = £ 113. 10

Quetiapine (as Quetiapine fumarate) 300 mgZaluron XL 300 mg

tablets| 60 tabletP£ 70. 71 DT = £ 170. 00

Quetiapine (as Quetiapine fumarate) 400 mgZaluron XL 400 mg

tablets| 60 tabletP£ 93. 98 DT = £ 226. 20

Tablet

CAUTIONARY AND ADVISORY LABELS 2

▶Quetiapine (Non-proprietary)

Quetiapine (as Quetiapine fumarate) 25 mgQuetiapine 25 mg

tablets| 60 tabletP£ 38. 05 DT = £ 11. 16

Quetiapine (as Quetiapine fumarate) 100 mgQuetiapine 100 mg

tablets| 60 tabletP£ 107. 45 DT = £ 43. 54

Quetiapine (as Quetiapine fumarate) 150 mgQuetiapine 150 mg

tablets| 60 tabletP£ 107. 45 DT = £ 51. 42

Quetiapine (as Quetiapine fumarate) 200 mgQuetiapine 200 mg

tablets| 60 tabletP£ 107. 45 DT = £ 43. 69

Quetiapine (as Quetiapine fumarate) 300 mgQuetiapine 300 mg

tablets| 60 tabletP£ 161. 50 DT = £ 72. 57

▶Seroquel(AstraZeneca UK Ltd)

Quetiapine (as Quetiapine fumarate) 25 mgSeroquel 25 mg tablets

| 60 tabletP£ 48. 60 DT = £ 11. 16

Quetiapine (as Quetiapine fumarate) 100 mgSeroquel 100 mg

tablets| 60 tabletP£ 135. 72 DT = £ 43. 54

Quetiapine (as Quetiapine fumarate) 200 mgSeroquel 200 mg

tablets| 60 tabletP£ 135. 72 DT = £ 43. 69

Quetiapine (as Quetiapine fumarate) 300 mgSeroquel 300 mg

tablets| 60 tabletP£ 204. 00 DT = £ 72. 57

Oral suspension

▶Quetiapine (Non-proprietary)

Quetiapine (as Quetiapine fumarate) 20 mg per 1 mlQuetiapine

20 mg/ml oral suspension sugar free sugar-free| 150 mlP£ 95. 00

DT = £ 95. 00

eiiiiF 244

Risperidone 07-Feb-2018

lDRUG ACTIONRisperidone is a dopamine D 2 , 5 -HT 2 A,

alpha 1 -adrenoceptor, and histamine- 1 receptor

antagonist.

lINDICATIONS AND DOSE

Acute and chronic psychosis

▶BY MOUTH

▶Child 12–17 years (under expert supervision): 2 mg daily in

1 – 2 divided doses for day 1 , then 4 mg daily in

1 – 2 divided doses for day 2 , slower titration is

appropriate in some patients; usual dose 4 – 6 mg daily,

doses above 10 mg daily only if benefit considered to

outweigh risk; maximum 16 mg per day

Short-term monotherapy of mania in bipolar disorder

(under expert supervision)

▶BY MOUTH

▶Child 12–17 years:Initially 500 micrograms once daily,

then adjusted in steps of 0. 5 – 1 mg daily, adjusted

according to response; usual dose 2. 5 mg daily in

1 – 2 divided doses; maximum 6 mg per day

Short-term treatment (up to 6 weeks) of persistent

aggression in conduct disorder (under expert

supervision)

▶BY MOUTH

▶Child 5–17 years (body-weight up to 50 kg):Initially

250 micrograms once daily, then increased in steps of

250 micrograms once daily on alternate days, adjusted

according to response; usual dose 500 micrograms

once daily; maximum 750 micrograms per day

▶Child 5–17 years (body-weight 50 kg and above):Initially

500 micrograms once daily, then increased in steps of

500 micrograms once daily on alternate continued→

BNFC 2018 – 2019 Psychoses and schizophrenia 253

Nervous system

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