Oxycodone hydrochloride 10 mgShortec 10 mg capsules|
56 capsuleP£ 13. 72 DT = £ 22. 86 b
Oxycodone hydrochloride 20 mgShortec 20 mg capsules|
56 capsuleP£ 27. 43 DT = £ 45. 71 beiiiiF 273Papaveretum 14-Mar-2018
lINDICATIONS AND DOSE
Postoperative analgesia|Severe chronic pain
▶BY SUBCUTANEOUS INJECTION, OR BY INTRAMUSCULAR
INJECTION
▶Neonate: 115 micrograms/kg every 4 hours if required.▶Child 1–11 months: 154 micrograms/kg every 4 hours if
required
▶Child 1–5 years: 1. 93 – 3. 85 mg every 4 hours if required
▶Child 6–11 years: 3. 85 – 7. 7 mg every 4 hours if required
▶Child 12–17 years: 7. 7 – 15. 4 mg every 4 hours if required
▶BY INTRAVENOUS INJECTION
▶Neonate:Use 25 to 50 % of the corresponding
subcutaneous/intramuscular dose.▶Child:Use 25 to 50 % of the corresponding
subcutaneous/intramuscular dose
Premedication
▶BY SUBCUTANEOUS INJECTION, OR BY INTRAMUSCULAR
INJECTION
▶Neonate: 115 micrograms/kg.▶Child 1–11 months: 154 micrograms/kg
▶Child 1–5 years: 1. 93 – 3. 85 mg
▶Child 6–11 years: 3. 85 – 7. 7 mg
▶Child 12–17 years: 7. 7 – 15. 4 mgIMPORTANT SAFETY INFORMATION
Donotconfuse with papaverine.lCONTRA-INDICATIONSHeart failure secondary to chronic
lung disease.phaeochromocytoma
lCAUTIONSSupraventricular tachycardia
lINTERACTIONS→Appendix 1 : opioids
lSIDE-EFFECTSBiliary spasm.dysuria.hypothermia.mood
altered.postural hypotension.sexual dysfunction.
ureteral spasm
lBREAST FEEDINGTherapeutic doses unlikely to affect
infant.
lRENAL IMPAIRMENTAvoid use or reduce dose; opioid
effects increased and prolonged and increased cerebral
sensitivity occurs.
lPRESCRIBING AND DISPENSING INFORMATIONThe name
Omnopon®was formerly used for papaveretum
preparations.
Papaveretum is a mixture of 253 parts of morphine
hydrochloride, 23 parts of papaverine hydrochloride and
20 parts of codeine hydrochloride.
lLESS SUITABLE FOR PRESCRIBINGPapaveretum is less
suitable for prescribing.
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: solution for injection
Solution for injection
▶Papaveretum (Non-proprietary)
Papaveretum 15.4 mg per 1 mlPapaveretum 15. 4 mg/ 1 ml solution
for injection ampoules| 10 ampouleP£ 48. 96 b
eiiiiF 273Pethidine hydrochloride
(Meperidine)
lINDICATIONS AND DOSE
Obstetric analgesia
▶BY SUBCUTANEOUS INJECTION, OR BY INTRAMUSCULAR
INJECTION
▶Child 12–17 years: 1 mg/kg (max. per dose 100 mg), then
1 mg/kg after 1 – 3 hours if required; maximum 400 mg
per daylCONTRA-INDICATIONSPhaeochromocytoma
lCAUTIONSAccumulation of metabolites may result in
neurotoxicity.cardiac arrhythmias.not suitable for severe
continuing pain.severe cor pulmonale
lINTERACTIONS→Appendix 1 : opioids
lSIDE-EFFECTSAnxiety.asthenia.biliary spasm.
coordination abnormal.delirium.dysuria.hypothermia.
seizure.syncope.tremor
Overdose Convulsions reported in overdosage.
lBREAST FEEDINGPresent in milk but not known to be
harmful.
lRENAL IMPAIRMENTAvoid use or reduce dose; opioid
effects increased and prolonged and increased cerebral
sensitivity occurs.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: solution for injection
Solution for injection
▶Pethidine hydrochloride (Non-proprietary)
Pethidine hydrochloride 10 mg per 1 mlPethidine 50 mg/ 5 ml
solution for injection ampoules| 10 ampouleP£ 52. 91 b
Pethidine hydrochloride 50 mg per 1 mlPethidine 50 mg/ 1 ml
solution for injection ampoules| 10 ampouleP£ 5. 11 DT =
£ 5. 11 b
Pethidine 100 mg/ 2 ml solution for injection ampoules|
10 ampouleP£ 4. 66 DT = £ 4. 66 beiiiiF 273Tramadol hydrochloride
lINDICATIONS AND DOSE
Moderate to severe pain
▶BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS
INJECTION, OR BY INTRAVENOUS INFUSION
▶Child 12–17 years: 50 – 100 mg every 4 – 6 hours,
intravenous injection to be given over 2 – 3 minutes
Moderate to severe acute pain
▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES
▶Child 12–17 years:Initially 100 mg, then 50 – 100 mg
every 4 – 6 hours; Usual maximum 400 mg/ 24 hours
Moderate to severe chronic pain
▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES
▶Child 12–17 years:Initially 50 mg, then, adjusted
according to response; Usual maximum
400 mg/ 24 hours
Postoperative pain
▶BY INTRAVENOUS INJECTION
▶Child 12–17 years:Initially 100 mg, then 50 mg every
10 – 20 minutes if required up to total maximum 250 mg
(including initial dose) infirst hour, then 50 – 100 mg
every 4 – 6 hours, intravenous injection to be given over
2 – 3 minutes; maximum 600 mg per day continued→BNFC 2018 – 2019 Pain 287
Nervous system4