Serious susceptible infections due to sensitive Gram-
positive and Gram-negative bacteria
▶BY MOUTH
▶Child 1 month–11 years: 25 mg/kg 2 – 4 times a day (max.
per dose 1 g 4 times a day)
▶Child 12–17 years: 1 – 1. 5 g 3 – 4 times a day
Prophylaxis of recurrent urinary-tract infection
▶BY MOUTH
▶Child: 12. 5 mg/kg once daily (max. per dose 125 mg),
dose to be taken at nightlINTERACTIONS→Appendix 1 : cephalosporins
lSIDE-EFFECTSAgitation.arthritis.confusion.fatigue.
gastrointestinal discomfort.genital pruritus.
hallucination.hepatitis (transient).hypersensitivity.
jaundice cholestatic (transient).joint disorders.vaginal
discharge
lPREGNANCYNot known to be harmful.
lBREAST FEEDINGPresent in milk in low concentration, but
appropriate to use.
lRENAL IMPAIRMENT
Dose adjustmentsReduce dose in moderate impairment.
lPATIENT AND CARER ADVICE
Medicines for Children leaflet: Cefalexin for bacterial
infectionswww.medicinesforchildren.org.uk/cefalexin-
bacterial-infections- 0
lPROFESSION SPECIFIC INFORMATION
Dental practitioners’formulary
Cefalexin Capsules may be prescribed. Cefalexin Tablets
may be prescribed. Cefalexin Oral Suspension may be
prescribed.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Oral suspension
CAUTIONARY AND ADVISORY LABELS 9
▶Cefalexin (Non-proprietary)
Cefalexin 25 mg per 1 mlCefalexin 125 mg/ 5 ml oral suspension
sugar free sugar-free| 100 mlP£ 0. 84
Cefalexin 125 mg/ 5 ml oral suspension| 100 mlP£ 4. 90 DT =
£ 0. 84
Cefalexin 50 mg per 1 mlCefalexin 250 mg/ 5 ml oral suspension
sugar free sugar-free| 100 mlP£ 1. 72 – £ 1. 90
Cefalexin 250 mg/ 5 ml oral suspension| 100 mlP£ 5. 25 DT =
£ 1. 90
Cefalexin 100 mg per 1 mlCefalexin 500 mg/ 5 ml oral suspension|
100 mlPs
▶Keflex(Flynn Pharma Ltd)
Cefalexin 25 mg per 1 mlKeflex 125 mg/ 5 ml oral suspension|
100 mlP£ 0. 84 DT = £ 0. 84
Cefalexin 50 mg per 1 mlKeflex 250 mg/ 5 ml oral suspension|
100 mlP£ 1. 40 DT = £ 1. 90
Tablet
CAUTIONARY AND ADVISORY LABELS 9
▶Cefalexin (Non-proprietary)
Cefalexin 250 mgCefalexin 250 mg tablets| 28 tabletP£ 5. 02
DT = £ 1. 50
Cefalexin 500 mgCefalexin 500 mg tablets| 21 tabletP£ 5. 88
DT = £ 1. 84
▶Keflex(Flynn Pharma Ltd)
Cefalexin 250 mgKeflex 250 mg tablets| 28 tabletP£ 1. 60 DT =
£ 1. 50
Cefalexin 500 mgKeflex 500 mg tablets| 21 tabletP£ 2. 08 DT =
£ 1. 84
Capsule
CAUTIONARY AND ADVISORY LABELS 9
▶Cefalexin (Non-proprietary)
Cefalexin 250 mgCefalexin 250 mg capsules| 28 capsuleP
£ 4. 01 DT = £ 1. 46
Cefalexin 500 mgCefalexin 500 mg capsules| 21 capsuleP
£ 4. 45 DT = £ 1. 79 | 100 capsuleP£ 9. 43
▶Keflex(Flynn Pharma Ltd)
Cefalexin 250 mgKeflex 250 mg capsules| 28 capsuleP£ 1. 46
DT = £ 1. 46Cefalexin 500 mgKeflex 500 mg capsules| 21 capsuleP£ 1. 98
DT = £ 1. 79eiiiiF 317Cefradine
(Cephradine)
lINDICATIONS AND DOSE
Susceptible infections due to sensitive Gram-positive and
Gram-negative bacteria|Surgical prophylaxis
▶BY MOUTH
▶Child 7–11 years: 25 – 50 mg/kg daily in 2 – 4 divided doses
▶Child 12–17 years: 250 – 500 mg 4 times a day,
alternatively 0. 5 – 1 g twice daily; increased if necessary
up to 1 g 4 times a day, increased dose may be used in
severe infections
Prevention ofStaphylococcus aureuslung infection in
cystic fibrosis
▶BY MOUTH
▶Child 7–17 years: 2 g twice dailylUNLICENSED USENot licensed for use in children for
prevention ofStaphylococcus aureuslung infection in
cysticfibrosis.
lINTERACTIONS→Appendix 1 : cephalosporins
lSIDE-EFFECTSAkathisia.aplastic anaemia.arthralgia.
blood disorder.chest tightness.confusion.
gastrointestinal discomfort.glossitis.hepatitis (transient)
.hypersensitivity.increased risk of infection.jaundice
cholestatic.muscle tone increased.nervousness.oedema
.sleep disorder
lPREGNANCYNot known to be harmful.
lBREAST FEEDINGPresent in milk in low concentration, but
appropriate to use.
lRENAL IMPAIRMENT
Dose adjustmentsReduce dose if estimated glomerular
filtration rate less than 20 mL/minute/ 1. 73 m^2.
lPROFESSION SPECIFIC INFORMATION
Dental practitioners’formulary
Cefradine Capsules may be prescribed.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Capsule
CAUTIONARY AND ADVISORY LABELS 9
▶Cefradine (Non-proprietary)
Cefradine 250 mgCefradine 250 mg capsules| 20 capsuleP
£ 6. 00 DT = £ 2. 25
Cefradine 500 mgCefradine 500 mg capsules| 20 capsuleP
£ 8. 75 DT = £ 3. 33
▶Nicef(Strides Shasun (UK) Ltd)
Cefradine 250 mgNicef 250 mg capsules| 20 capsuleP£ 3. 55
DT = £ 2. 25 | 100 capsuleP£ 9. 39
Cefradine 500 mgNicef 500 mg capsules| 20 capsuleP£ 5. 58
DT = £ 3. 33 | 100 capsuleP£ 33. 72ANTIBACTERIALS›CEPHALOSPORINS,
SECOND-GENERATION
eiiiiF 317Cefaclor
lINDICATIONS AND DOSE
Susceptible infections due to sensitive Gram-positive and
Gram-negative bacteria
▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES
▶Child 1–11 months: 20 mg/kg daily in 3 divided doses,
alternatively 62. 5 mg 3 times a day
▶Child 1–4 years: 20 mg/kg daily in 3 divided doses,
alternatively 125 mg 3 times a day318 Bacterial infection BNFC 2018 – 2019
Infection5