▶Child 5–11 years: 20 mg/kg daily in 3 divided doses, usual
max. 1 g daily, alternatively 250 mg 3 times a day
▶Child 12–17 years: 250 mg 3 times a day; maximum 4 g
per day
▶BY MOUTH USING MODIFIED-RELEASE MEDICINES
▶Child 12–17 years: 375 mg every 12 hours, dose to be
taken with food
Severe susceptible infections due to sensitive Gram-
positive and Gram-negative bacteria
▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES
▶Child 1–11 months: 40 mg/kg daily in 3 divided doses,
usual max. 1 g daily, alternatively 125 mg 3 times a day
▶Child 1–4 years: 40 mg/kg daily in 3 divided doses, usual
max. 1 g daily, alternatively 250 mg 3 times a day
▶Child 5–11 years: 40 mg/kg daily in 3 divided doses, usual
max. 1 g daily
▶Child 12–17 years: 500 mg 3 times a day; maximum 4 g
per day
Pneumonia
▶BY MOUTH USING MODIFIED-RELEASE TABLETS
▶Child 12–17 years: 750 mg every 12 hours, dose to be
taken with food
Lower urinary-tract infections
▶BY MOUTH USING MODIFIED-RELEASE MEDICINES
▶Child 12–17 years: 375 mg every 12 hours, dose to be
taken with food
Asymptomatic carriage ofHaemophilus influenzaeor mild
exacerbations in cystic fibrosis
▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES
▶Child 1–11 months: 125 mg every 8 hours
▶Child 1–6 years: 250 mg 3 times a day
▶Child 7–17 years: 500 mg 3 times a daylINTERACTIONS→Appendix 1 : cephalosporins
lSIDE-EFFECTSAkathisia.anxiety.aplastic anaemia.
arthralgia.arthritis.asthenia.colitis.confusion.
drowsiness.dyspnoea.fever.genital pruritus.
hallucination.hepatitis (transient).hypersensitivity.
insomnia.jaundice cholestatic (transient).
lymphadenopathy.lymphocytosis.muscle tone increased
.oedema.paraesthesia.proteinuria.syncope.
vasodilation
SIDE-EFFECTS, FURTHER INFORMATIONCefaclor is
associated with protracted skin reactions, especially in
children.
lPREGNANCYNot known to be harmful.
lBREAST FEEDINGPresent in milk in low concentration, but
appropriate to use.
lRENAL IMPAIRMENTManufacturer advises caution.
Dose adjustmentsNo dose adjustment required.
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Oral suspension
CAUTIONARY AND ADVISORY LABELS 9
▶Cefaclor (Non-proprietary)
Cefaclor (as Cefaclor monohydrate) 25 mg per 1 mlCefaclor
125 mg/ 5 ml oral suspension| 100 mlPs
Cefaclor (as Cefaclor monohydrate) 50 mg per 1 mlCefaclor
250 mg/ 5 ml oral suspension| 100 mlPs
▶Distaclor(Flynn Pharma Ltd)
Cefaclor (as Cefaclor monohydrate) 25 mg per 1 mlDistaclor
125 mg/ 5 ml oral suspension| 100 mlP£ 4. 13
Cefaclor (as Cefaclor monohydrate) 50 mg per 1 mlDistaclor
250 mg/ 5 ml oral suspension| 100 mlP£ 8. 26
▶Keftid(Strides Shasun (UK) Ltd)
Cefaclor (as Cefaclor monohydrate) 25 mg per 1 mlKeftid
125 mg/ 5 ml oral suspension sugar-free| 100 mlP£ 5. 16 DT =
£ 5. 16
Cefaclor (as Cefaclor monohydrate) 50 mg per 1 mlKeftid
250 mg/ 5 ml oral suspension sugar-free| 100 mlP£ 10. 32 DT =
£ 10. 32
Modified-release tablet
CAUTIONARY AND ADVISORY LABELS9, 21, 25
▶Distaclor MR(Flynn Pharma Ltd)
Cefaclor (as Cefaclor monohydrate) 375 mgDistaclor MR 375 mg
tablets| 14 tabletP£ 9. 10 DT = £ 9. 10
Capsule
CAUTIONARY AND ADVISORY LABELS 9
▶Cefaclor (Non-proprietary)
Cefaclor (as Cefaclor monohydrate) 250 mgCefaclor 250 mg
capsules| 21 capsulePsDT = £ 6. 80
▶Distaclor(Flynn Pharma Ltd)
Cefaclor (as Cefaclor monohydrate) 500 mgDistaclor 500 mg
capsules| 21 capsuleP£ 7. 50 DT = £ 7. 50
▶Keftid(Strides Shasun (UK) Ltd)
Cefaclor (as Cefaclor monohydrate) 250 mgKeftid 250 mg capsules
| 21 capsuleP£ 6. 80 DT = £ 6. 80
Cefaclor (as Cefaclor monohydrate) 500 mgKeftid 500 mg
capsules| 50 capsuleP£ 31. 99
eiiiiF 317Cefuroxime 17-Mar-2017
lINDICATIONS AND DOSE
Susceptible infections due to Gram-positive and Gram-
negative bacteria
▶BY MOUTH
▶Child 3 months–1 year: 10 mg/kg twice daily (max. per
dose 125 mg)
▶Child 2–11 years: 15 mg/kg twice daily (max. per dose
250 mg)
▶Child 12–17 years: 250 mg twice daily, dose may be
doubled in severe lower respiratory-tract infections or
if pneumonia is suspected
▶BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION
▶Neonate up to 7 days: 25 mg/kg every 12 hours, increased
if necessary to 50 mg/kg every 12 hours, increased dose
used in severe infection.▶Neonate 7 days to 20 days: 25 mg/kg every 8 hours,
increased if necessary to 50 mg/kg every 8 hours,
increased dose used in severe infection.▶Neonate 21 days to 28 days: 25 mg/kg every 6 hours,
increased if necessary to 50 mg/kg every 6 hours,
increased dose used in severe infection.▶BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION,
OR BY INTRAMUSCULAR INJECTION
▶Child: 20 mg/kg every 8 hours (max. per dose 750 mg);
increased to 50 – 60 mg/kg every 6 – 8 hours (max. per
dose 1. 5 g), increased dose used for severe infection
and cysticfibrosis
Lyme disease
▶BY MOUTH
▶Child 3 months–11 years: 15 mg/kg twice daily (max. per
dose 500 mg) for 14 – 21 days (for 28 days in Lyme
arthritis)
▶Child 12–17 years: 500 mg twice daily for 14 – 21 days (for
28 days in Lyme arthritis)
Lower urinary-tract infection
▶BY MOUTH
▶Child 12–17 years: 125 mg twice daily
Surgical prophylaxis
▶INITIALLY BY INTRAVENOUS INJECTION
▶Child: 50 mg/kg (max. per dose 1. 5 g), to be
administered up to 30 minutes before the procedure,
then (by intravenous injection or by intramuscular
injection) 30 mg/kg every 8 hours (max. per dose
750 mg) if required for up to 3 doses (for high-risk
procedures)BNFC 2018 – 2019 Bacterial infection 319
Infection5