Oral suspension
CAUTIONARY AND ADVISORY LABELS 9
▶Clarithromycin (Non-proprietary)
Clarithromycin 25 mg per 1 mlClarithromycin 125 mg/ 5 ml oral
suspension| 70 mlP£ 3. 75 DT = £ 3. 39
Clarithromycin 50 mg per 1 mlClarithromycin 250 mg/ 5 ml oral
suspension| 70 mlP£ 5. 25 DT = £ 4. 60
▶Klaricid(Mylan)
Clarithromycin 25 mg per 1 mlKlaricid Paediatric 125 mg/ 5 ml oral
suspension| 70 mlP£ 5. 26 DT = £ 3. 39 | 100 mlP£ 9. 04
Clarithromycin 50 mg per 1 mlKlaricid Paediatric 250 mg/ 5 ml oral
suspension| 70 mlP£ 10. 51 DT = £ 4. 60
Powder for solution for infusion
ELECTROLYTES:May contain Sodium
▶Clarithromycin (Non-proprietary)
Clarithromycin 500 mgClarithromycin 500 mg powder for solution
for infusion vials| 1 vialP£ 11. 25 DT = £ 9. 45
Clarithromycin 500 mg powder for concentrate for solution for infusion
vials| 1 vialP£ 8. 98 DT = £ 9. 45
▶Klaricid(Mylan)
Clarithromycin 500 mgKlaricid IV 500 mg powder for solution for
infusion vials| 1 vialP£ 9. 45 DT = £ 9. 45
eiiiiF 328
Erythromycin
lINDICATIONS AND DOSE
Susceptible infections in patients with penicillin
hypersensitivity (e.g. respiratory-tract infections
(including Legionella infection), skin and oral infections,
and campylobacter enteritis)
▶BY MOUTH
▶Neonate: 12. 5 mg/kg every 6 hours.
▶Child 1 month–1 year: 125 mg 4 times a day, total daily
dose may alternatively be given in two divided doses,
increased to 250 mg 4 times a day, dose increase may
be used in severe infections
▶Child 2–7 years: 250 mg 4 times a day, total daily dose
may alternatively be given in two divided doses,
increased to 500 mg 4 times a day, dose increase may
be used in severe infections
▶Child 8–17 years: 250 – 500 mg 4 times a day, total daily
dose may alternatively be given in two divided doses,
increased to 500 – 1000 mg 4 times a day, dose increase
may be used in severe infections
▶BY INTRAVENOUS INFUSION
▶Neonate: 10 – 12. 5 mg/kg every 6 hours.
▶Child: 12. 5 mg/kg every 6 hours (max. per dose 1 g)
Lyme disease (under expert supervision)
▶BY MOUTH
▶Child: 12. 5 mg/kg 4 times a day (max. per dose 500 mg)
for^14 –^21 days
Chlamydial ophthalmia
▶BY MOUTH
▶Neonate: 12. 5 mg/kg every 6 hours.
▶Child 1 month–1 year: 125 mg 4 times a day, increased to
250 mg every 6 hours, dose increase for severe
infections, total daily dose may alternatively be given
in two divided doses
▶Child 2–7 years: 250 mg 4 times a day, increased to
500 mg every 6 hours, dose increase for severe
infections, total daily dose may alternatively be given
in two divided doses
▶Child 8–17 years: 250 – 500 mg 4 times a day, increased
to 500 – 1000 mg every 6 hours, dose increase for severe
infections, total daily dose may alternatively be given
in two divided doses
▶BY INTRAVENOUS INFUSION
▶Neonate: 10 – 12. 5 mg/kg every 6 hours.
▶Child: 12. 5 mg/kg every 6 hours (max. per dose 1 g)
Early syphilis
▶BY MOUTH
▶Child 12–17 years: 500 mg 4 times a day for 14 days
Uncomplicated genital chlamydia|Non-gonococcal
urethritis
▶BY MOUTH
▶Child 1 month–1 year: 12. 5 mg/kg 4 times a day for
14 days
▶Child 2–11 years: 250 mg twice daily for 14 days
▶Child 12–17 years: 500 mg twice daily for 14 days
Pelvic inflammatory disease
▶BY MOUTH
▶Child 1 month–1 year: 12. 5 mg/kg 4 times a day for
14 days
▶Child 2–11 years: 250 mg twice daily for 14 days
▶Child 12–17 years: 500 mg twice daily for 14 days
Prevention and treatment of pertussis
▶BY MOUTH
▶Neonate: 12. 5 mg/kg every 6 hours.▶Child 1 month–1 year: 125 mg 4 times a day, total daily
dose may alternatively be given in two divided doses,
increased to 250 mg 4 times a day, dose increase may
be used in severe infections
▶Child 2–7 years: 250 mg 4 times a day, total daily dose
may alternatively be given in two divided doses,
increased to 500 mg 4 times a day, dose increase may
be used in severe infections
▶Child 8–17 years: 250 – 500 mg 4 times a day, total daily
dose may alternatively be given in two divided doses,
increased to 500 – 1000 mg 4 times a day, dose increase
may be used in severe infections
▶BY INTRAVENOUS INFUSION
▶Neonate: 10 – 12. 5 mg/kg every 6 hours.▶Child: 12. 5 mg/kg every 6 hours (max. per dose 1 g)
Prevention of secondary case of diphtheria in non-
immune patient
▶BY MOUTH
▶Child 1 month–1 year: 125 mg every 6 hours for 7 days,
treat for further 10 days if nasopharyngeal swabs
positive afterfirst 7 days’treatment
▶Child 2–7 years: 250 mg every 6 hours for 7 days, treat
for further 10 days if nasopharyngeal swabs positive
afterfirst 7 days’treatment
▶Child 8–17 years: 500 mg every 6 hours for 7 days, treat
for further 10 days if nasopharyngeal swabs positive
afterfirst 7 days’treatment
Prevention of secondary case of invasive group A
streptococcal infection in penicillin allergic patients
▶BY MOUTH
▶Child 1 month–1 year: 125 mg every 6 hours for 10 days
▶Child 2–7 years: 250 mg every 6 hours for 10 days
▶Child 8–17 years: 250 – 500 mg every 6 hours for 10 days
Prevention of pneumococcal infection in asplenia or in
patients with sickle-cell disease (if penicillin-allergic)
▶BY MOUTH
▶Child 1 month–1 year: 125 mg twice daily, antibiotic
prophylaxis is not fully reliable
▶Child 2–7 years: 250 mg twice daily, antibiotic
prophylaxis is not fully reliable. It may be discontinued
in those over 5 years of age with sickle-cell disease who
have received pneumococcal immunisation and who do
not have a history of severe pneumococcal infection
▶Child 8–17 years: 500 mg twice daily, antibiotic
prophylaxis is not fully reliable. It may be discontinued
in those with sickle-cell disease who have received
pneumococcal immunisation and who do not have a
history of severe pneumococcal infection continued→BNFC 2018 – 2019 Bacterial infection 331
Infection5