Prevention of recurrence of rheumatic fever
▶BY MOUTH
▶Child 1 month–1 year: 125 mg twice daily
▶Child 2–17 years: 250 mg twice daily
Acne
▶BY MOUTH
▶Child 1–23 months: 250 mg once daily, alternatively
125 mg twice daily
▶Child 12–17 years: 500 mg twice daily
Gastro-intestinal stasis
▶BY MOUTH
▶Neonate: 3 mg/kg 4 times a day.▶Child: 3 mg/kg 4 times a day
▶BY INTRAVENOUS INFUSION
▶Neonate: 3 mg/kg 4 times a day.▶Child 1–11 months: 3 mg/kg 4 times a daylUNLICENSED USENot licensed for use in gastro-intestinal
stasis.
lCAUTIONSAvoid in Acute porphyrias p. 603 .neonate
under 2 weeks (risk of hypertrophic pyloric stenosis)
lINTERACTIONS→Appendix 1 : macrolides
lPREGNANCYNot known to be harmful.
lBREAST FEEDINGOnly small amounts in milk—not known
to be harmful.
lHEPATIC IMPAIRMENTMay cause idiosyncratic
hepatotoxicity.
lRENAL IMPAIRMENT
Dose adjustmentsReduce dose in severe renal impairment
(ototoxicity).
lDIRECTIONS FOR ADMINISTRATION
▶With intravenous useDilute reconstituted solution further in
glucose 5 % (neutralised with Sodium bicarbonate) or
sodium chloride 0. 9 % to a concentration of 1 – 5 mg/mL;
give over 20 – 60 minutes. Concentration of up to 10 mg/mL
may be used influid-restriction if administered via a
central venous catheter.
lPRESCRIBING AND DISPENSING INFORMATIONFlavours of
oral liquid formulations may include banana.
lPATIENT AND CARER ADVICE
Medicines for Children leaflet: Erythromycin for bacterial
infectionswww.medicinesforchildren.org.uk/erythromycin-for-
bacterial-infections
lPROFESSION SPECIFIC INFORMATION
Dental practitioners’formulary
Erythromycin tablets e/c may be prescribed. Erythromycin
ethyl succinate oral suspension may be prescribed.
Erythromycin stearate tablets may be prescribed.
Erythromycin ethyl succinate tablets may be prescribed.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Gastro-resistant tablet
CAUTIONARY AND ADVISORY LABELS5, 9, 25
▶Erythromycin (Non-proprietary)
Erythromycin 250 mgErythromycin 250 mg gastro-resistant tablets
| 28 tabletP£ 2. 25 DT = £ 1. 28 | 500 tabletP£ 22. 86 – £ 27. 20
Tablet
CAUTIONARY AND ADVISORY LABELS 9
▶Erythromycin (Non-proprietary)
Erythromycin (as Erythromycin ethyl succinate)
500 mgErythromycin ethyl succinate 500 mg tablets|
28 tabletP£ 15. 95 DT = £ 10. 78
▶Erythrocin(AMCo)
Erythromycin (as Erythromycin stearate) 250 mgErythrocin
250 tablets| 100 tabletP£ 18. 20 DT = £ 18. 20
Erythromycin (as Erythromycin stearate) 500 mgErythrocin
500 tablets| 100 tabletP£ 36. 40 DT = £ 36. 40▶Erythrolar(Ennogen Pharma Ltd)
Erythromycin (as Erythromycin stearate) 250 mgErythrolar
250 mg tablets| 100 tabletP£ 22. 80 DT = £ 18. 20
Erythromycin (as Erythromycin stearate) 500 mgErythrolar
500 mg tablets| 100 tabletP£ 45. 60 DT = £ 36. 40
▶Erythroped A(AMCo)
Erythromycin (as Erythromycin ethyl succinate)
500 mgErythroped A 500 mg tablets| 28 tabletP£ 10. 78 DT =
£ 10. 78
Oral suspension
CAUTIONARY AND ADVISORY LABELS 9
▶Erythromycin (Non-proprietary)
Erythromycin (as Erythromycin ethyl succinate) 25 mg per
1mlErythromycin ethyl succinate 125 mg/ 5 ml oral suspension|
100 mlP£ 4. 80 DT = £ 4. 75
Erythromycin ethyl succinate 125 mg/ 5 ml oral suspension sugar free
sugar-free| 100 mlP£ 4. 99 DT = £ 3. 61
Erythromycin (as Erythromycin ethyl succinate) 50 mg per
1mlErythromycin ethyl succinate 250 mg/ 5 ml oral suspension|
100 mlP£ 8. 18 DT = £ 8. 14
Erythromycin ethyl succinate 250 mg/ 5 ml oral suspension sugar free
sugar-free| 100 mlP£ 7. 43 DT = £ 6. 22
Erythromycin (as Erythromycin ethyl succinate) 100 mg per
1mlErythromycin ethyl succinate 500 mg/ 5 ml oral suspension|
100 mlP£ 14. 54 DT = £ 14. 54
Erythromycin ethyl succinate 500 mg/ 5 ml oral suspension sugar free
sugar-free| 100 mlPs
▶Erythroped(AMCo)
Erythromycin (as Erythromycin ethyl succinate) 25 mg per
1mlErythroped PI SF 125 mg/ 5 ml oral suspension sugar-free|
140 mlP£ 3. 06
Erythromycin (as Erythromycin ethyl succinate) 50 mg per
1mlErythroped SF 250 mg/ 5 ml oral suspension sugar-free|
140 mlP£ 5. 95
Erythromycin (as Erythromycin ethyl succinate) 100 mg per
1mlErythroped Forte SF 500 mg/ 5 ml oral suspension sugar-free|
140 mlP£ 10. 56 DT = £ 10. 56
Powder for solution for infusion
▶Erythromycin (Non-proprietary)
Erythromycin (as Erythromycin lactobionate)
1 gramErythromycin 1 g powder for solution for infusion vials|
1 vialP£ 18. 45 – £ 22. 92ANTIBACTERIALS›MONOBACTAMS
Aztreonam
lDRUG ACTIONAztreonam is a monocyclic beta-lactam
(‘monobactam’) antibiotic with an antibacterial spectrum
limited to Gram-negative aerobic bacteria including
Pseudomonas aeruginosa,Neisseria meningitidis, and
Haemophilus influenzae; it should not be used alone for
‘blind’treatment since it is not active against Gram-
positive organisms. Aztreonam is also effective against
Neisseria gonorrhoeae(but not against concurrent
chlamydial infection).lINDICATIONS AND DOSE
Gram-negative infections includingPseudomonas
aeruginosa,Haemophilus influenzae, andNeisseria
meningitidis
▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION
▶Neonate up to 7 days: 30 mg/kg every 12 hours.▶Neonate 7 days to 28 days: 30 mg/kg every 6 – 8 hours.▶Child 1 month–11 years: 30 mg/kg every 6 – 8 hours
▶Child 12–17 years: 1 g every 8 hours, alternatively 2 g
every 12 hours
Severe gram-negative infections includingPseudomonas
aeruginosa,Haemophilus influenzae,Neisseria
meningitidis, and lung infections in cystic fibrosis
▶BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION
▶Child 2–11 years: 50 mg/kg every 6 – 8 hours (max. per
dose 2 g 4 times a day)332 Bacterial infection BNFC 2018 – 2019
Infection5