lLESS SUITABLE FOR PRESCRIBINGLess suitable for
prescribing (compared with other tetracyclines,
minocycline is associated with a greater risk of lupus-
erythematosus-like syndrome; it sometimes causes
irreversible pigmentation).lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension, oral solution
Tablet
CAUTIONARY AND ADVISORY LABELS6, 9
▶Minocycline (Non-proprietary)
Minocycline (as Minocycline hydrochloride) 50 mgMinocycline
50 mg tablets| 28 tabletP£ 8. 50 DT = £ 6. 19
Minocycline (as Minocycline hydrochloride) 100 mgMinocycline
100 mg tablets| 28 tabletP£ 14. 50 DT = £ 14. 01
Modified-release capsule
CAUTIONARY AND ADVISORY LABELS6, 25
▶Minocycline (Non-proprietary)
Minocycline (as Minocycline hydrochloride) 100 mgMinocycline
100 mg modified-release capsules| 56 capsuleP£ 20. 08 DT =
£ 20. 08
▶Acnamino MR(Dexcel-Pharma Ltd)
Minocycline (as Minocycline hydrochloride) 100 mgAcnamino MR
100 mg capsules| 56 capsuleP£ 21. 14 DT = £ 20. 08
▶Minocin MR(Meda Pharmaceuticals Ltd)
Minocycline (as Minocycline hydrochloride) 100 mgMinocin MR
100 mg capsules| 56 capsuleP£ 20. 08 DT = £ 20. 08
Capsule
CAUTIONARY AND ADVISORY LABELS6, 9
▶Aknemin(Almirall Ltd)
Minocycline (as Minocycline hydrochloride) 50 mgAknemin 50
capsules| 56 capsuleP£ 15. 27 DT = £ 15. 27
Minocycline (as Minocycline hydrochloride) 100 mgAknemin
100 mg capsules| 28 capsuleP£ 13. 09 DT = £ 13. 09
eiiiiF 352Oxytetracycline
lINDICATIONS AND DOSE
Susceptible infections (e.g. chlamydia, rickettsia and
mycoplasma)
▶BY MOUTH
▶Child 12–17 years: 250 – 500 mg 4 times a day
Acne
▶BY MOUTH
▶Child 12–17 years: 500 mg twice daily for at least
3 months, if there is no improvement after thefirst
3 months another oral antibacterial should be used,
maximum improvement usually occurs after 4 to
6 months but in more severe cases treatment may need
to be continued for 2 years or longerlINTERACTIONS→Appendix 1 : tetracyclines
lSIDE-EFFECTSGastrointestinal discomfort.hepatic
steatosis.increased risk of infection.renal impairment
lRENAL IMPAIRMENTMay exacerbate renal failure and
shouldnotbe given to patients with renal impairment.
lPROFESSION SPECIFIC INFORMATION
Dental practitioners’formulary
Oxytetracycline Tablets may be prescribed.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension
Tablet
CAUTIONARY AND ADVISORY LABELS7, 9, 23
▶Oxytetracycline (Non-proprietary)
Oxytetracycline (as Oxytetracycline dihydrate)
250 mgOxytetracycline 250 mg tablets| 28 tabletP£ 0. 79 DT =
£ 0. 47eiiiiF 352Tetracycline
lINDICATIONS AND DOSE
Susceptible infections (e.g. chlamydia, rickettsia,
mycoplasma)
▶BY MOUTH
▶Child 12–17 years: 250 mg 4 times a day, increased if
necessary to 500 mg 3 – 4 times a day, increased dose
used in severe infections
Acne
▶BY MOUTH
▶Child 12–17 years: 500 mg twice daily for at least
3 months, if there is no improvement after thefirst
3 months another oral antibacterial should be used,
maximum improvement usually occurs after 4 to
6 months but in more severe cases treatment may need
to be continued for 2 years or longer
Non-gonococcal urethritis
▶BY MOUTH
▶Child 12–17 years: 500 mg 4 times a day for 7 – 14 days
( 21 days if failure or relapse afterfirst course)lINTERACTIONS→Appendix 1 : tetracyclines
lSIDE-EFFECTS
▶Rare or very rareAgranulocytosis.aplastic anaemia.
nephritis.renal impairment
▶Frequency not knownGastrointestinal discomfort.hepatic
steatosis.overgrowth of nonsusceptible organisms.toxic
epidermal necrolysis
lHEPATIC IMPAIRMENT
Dose adjustmentsMax. 1 g daily in divided doses.
lRENAL IMPAIRMENTMay exacerbate renal failure and
shouldnotbe given to patients with renal impairment.
lDIRECTIONS FOR ADMINISTRATIONTablets should be
swallowed whole with plenty offluid while sitting or
standing.
lPATIENT AND CARER ADVICECounselling on
administration advised.
lPROFESSION SPECIFIC INFORMATION
Dental practitioners’formulary
Tetracycline Tablets may be prescribed.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: capsule, oral solution
Tablet
CAUTIONARY AND ADVISORY LABELS7, 9, 23
▶Tetracycline (Non-proprietary)
Tetracycline hydrochloride 250 mgTetracycline 250 mg tablets|
28 tabletP£ 13. 90 DT = £ 1. 27ANTIBACTERIALS›OTHER
Chloramphenicol
lDRUG ACTIONChloramphenicol is a potent broad-
spectrum antibiotic.lINDICATIONS AND DOSE
Life threatening infections particularly those caused by
Haemophilus influenzae|Typhoid fever
▶BY MOUTH, OR BY INTRAVENOUS INJECTION, OR BY
INTRAVENOUS INFUSION
▶Child: 12. 5 mg/kg every 6 hours, dose may be doubled
in severe infections such as septicaemia, meningitis
and epiglottitis providing plasma-chloramphenicol
concentrations are measured and high doses reduced
as soon as indicated354 Bacterial infection BNFC 2018 – 2019
Infection5