lPRESCRIBING AND DISPENSING INFORMATIONInsulin
lispro is a biological medicine. Biological medicines must
be prescribed and dispensed by brand name, seeBiological
medicinesandBiosimilar medicines, under Guidance on
prescribing p. 1.
lNATIONAL FUNDING/ACCESS DECISIONS
NICE decisions
▶Continuous subcutaneous insulin infusion for the treatment of
diabetes mellitus (type 1 ) (July 2008 )NICE TA151
Continuous subcutaneous insulin infusion is
recommended as an option in children over 12 years with
type 1 diabetes:
.who suffer repeated or unpredictable hypoglycaemia,
whilst attempting to achieve optimal glycaemic control
with multiple-injection regimens,or
.whose glycaemic control remains inadequate (HbA 1 c
over 8. 5 %[ 69 mmol/mol]) despite optimised multiple-
injection regimens (including the use of long-acting
insulin analogues where appropriate).
Continuous subcutaneous insulin infusion is also
recommended as an option for children under^12 years
with type 1 diabetes for whom multiple-injection regimens
are considered impractical or inappropriate. Children on
insulin pumps should undergo a trial of multiple-injection
therapy between the ages of 12 and 18 years.
http://www.nice.org.uk/TA151
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Solution for injection
▶Humalog(Eli Lilly and Company Ltd)
Insulin lispro 100 unit per 1 mlHumalog 100 units/ml solution for
injection 10 ml vials| 1 vialP£ 16. 61 DT = £ 16. 61
Humalog 100 units/ml solution for injection 3 ml cartridges|
5 cartridgeP£ 28. 31 DT = £ 28. 31
▶Humalog Junior KwikPen(Eli Lilly and Company Ltd)
Insulin lispro 100 unit per 1 mlHumalog Junior KwikPen
100 units/ml solution for injection 3 ml pre-filled pen| 5 pre-filled
disposable injectionP£ 29. 46 DT = £ 29. 46
▶Humalog KwikPen(Eli Lilly and Company Ltd)
Insulin lispro 100 unit per 1 mlHumalog KwikPen 100 units/ml
solution for injection 3 ml pre-filled pen| 5 pre-filled disposable
injectionP£ 29. 46 DT = £ 29. 46
Insulin lispro 200 unit per 1 mlHumalog KwikPen 200 units/ml
solution for injection 3 ml pre-filled pen| 5 pre-filled disposable
injectionP£ 58. 92
INSULINS›INTERMEDIATE-ACTING
eiiiiF 454
Biphasic isophane insulin
(Biphasic Isophane Insulin Injection—intermediate
acting)lINDICATIONS AND DOSE
Diabetes mellitus
▶BY SUBCUTANEOUS INJECTION
▶Child:According to requirementslINTERACTIONS→Appendix 1 : insulins
lSIDE-EFFECTS
▶Rare or very rareAngioedema
▶Frequency not knownHypokalaemia.weight increased
lPRESCRIBING AND DISPENSING INFORMATIONA sterile
buffered suspension of either porcine or human insulin
complexed with protamine sulfate (or another suitable
protamine) in a solution of insulin of the same species.
Check product container—the proportions of the two
components should be checked carefully (the order in
which the proportions are stated may not be the same in
other countries).
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Suspension for injection
▶Humulin M 3 (Eli Lilly and Company Ltd)
Insulin human (as Insulin soluble human) 30 unit per 1 ml,
Insulin human (as Insulin isophane human) 70 unit per
1mlHumulin M3 100units/ml suspension for injection 3 ml cartridges
| 5 cartridgeP£ 19. 08 DT = £ 19. 08
Humulin M3 100units/ml suspension for injection 10 ml vials|
1 vialP£ 15. 68
▶Humulin M 3 KwikPen(Eli Lilly and Company Ltd)
Insulin human (as Insulin soluble human) 30 unit per 1 ml,
Insulin human (as Insulin isophane human) 70 unit per
1mlHumulin M 3 KwikPen 100 units/ml suspension for injection 3 ml
pre-filled pen| 5 pre-filled disposable injectionP£ 21. 70 DT =
£ 21. 70
▶Hypurin Porcine 30 / 70 Mix(Wockhardt UK Ltd)
Insulin porcine (as Insulin soluble porcine) 30 unit per 1 ml,
Insulin porcine (as Insulin isophane porcine) 70 unit per
1mlHypurin Porcine 30 / 70 Mix 100 units/ml suspension for injection
3 ml cartridges| 5 cartridgeP£ 46. 95
Hypurin Porcine 30 / 70 Mix 100 units/ml suspension for injection 10 ml
vials| 1 vialP£ 31. 30
▶Insuman Comb 15 (Sanofi)
Insulin human (as Insulin soluble human) 15 unit per 1 ml, Insulin
human (as Insulin isophane human) 85 unit per 1 mlInsuman
Comb15 100units/ml suspension for injection 3 ml cartridges|
5 cartridgeP£ 17. 50
▶Insuman Comb 25 (Sanofi)
Insulin human (as Insulin soluble human) 25 unit per 1 ml, Insulin
human (as Insulin isophane human) 75 unit per 1 mlInsuman
Comb25 100units/ml suspension for injection 5 ml vials| 1 vialP
£ 5. 61
Insuman Comb25 100units/ml suspension for injection 3 ml pre-filled
SoloStar pen| 5 pre-filled disposable injectionP£ 19. 80
Insuman Comb25 100units/ml suspension for injection 3 ml cartridges
| 5 cartridgeP£ 17. 50
▶Insuman Comb 50 (Sanofi)
Insulin human (as Insulin isophane human) 50 unit per 1 ml,
Insulin human (as Insulin soluble human) 50 unit per
1mlInsuman Comb50 100units/ml suspension for injection 3 ml
cartridges| 5 cartridgeP£ 17. 50
eiiiiF 454Isophane insulin
(Isophane Insulin Injection; Isophane Protamine
Insulin Injection; Isophane Insulin (NPH)—
intermediate acting)lINDICATIONS AND DOSE
Diabetes mellitus
▶BY SUBCUTANEOUS INJECTION
▶Child:According to requirementslINTERACTIONS→Appendix 1 : insulins
lPREGNANCYRecommended where longer-acting insulins
are needed.
lPRESCRIBING AND DISPENSING INFORMATIONA sterile
suspension of bovine or porcine insulin or of human
insulin in the form of a complex obtained by the addition
of protamine sulfate or another suitable protamine.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Suspension for injection
▶Humulin I(Eli Lilly and Company Ltd)
Insulin human (as Insulin isophane human) 100 unit per
1mlHumulin I 100 units/ml suspension for injection 10 ml vials|
1 vialP£ 15. 68
Humulin I 100 units/ml suspension for injection 3 ml cartridges|
5 cartridgeP£ 19. 08 DT = £ 19. 08BNFC 2018 – 2019 Diabetes mellitus 457
Endocrine system6