▶Humulin I KwikPen(Eli Lilly and Company Ltd)
Insulin human (as Insulin isophane human) 100 unit per
1mlHumulin I KwikPen 100 units/ml suspension for injection 3 ml pre-
filled pen| 5 pre-filled disposable injectionP£ 21. 70 DT = £ 21. 70
▶Hypurin Bovine Isophane(Wockhardt UK Ltd)
Insulin bovine (as Insulin isophane bovine) 100 unit per
1mlHypurin Bovine Isophane 100 units/ml suspension for injection
10 ml vials| 1 vialP£ 27. 72
▶Hypurin Porcine Isophane(Wockhardt UK Ltd)
Insulin porcine (as Insulin isophane porcine) 100 unit per
1mlHypurin Porcine Isophane 100 units/ml suspension for injection
3 ml cartridges| 5 cartridgeP£ 46. 95
Hypurin Porcine Isophane 100 units/ml suspension for injection 10 ml
vials| 1 vialP£ 31. 30
▶Insulatard(Novo Nordisk Ltd)
Insulin human (as Insulin isophane human) 100 unit per
1mlInsulatard 100 units/ml suspension for injection 10 ml vials|
1 vialP£ 7. 48
▶Insulatard InnoLet(Novo Nordisk Ltd)
Insulin human (as Insulin isophane human) 100 unit per
1mlInsulatard InnoLet 100 units/ml suspension for injection 3 ml pre-
filled pen| 5 pre-filled disposable injectionP£ 20. 40 DT = £ 21. 70
▶Insulatard Penfill(Novo Nordisk Ltd)
Insulin human (as Insulin isophane human) 100 unit per
1mlInsulatard Penfill 100 units/ml suspension for injection 3 ml
cartridges| 5 cartridgeP£ 22. 90 DT = £ 19. 08
▶Insuman Basal(Sanofi)
Insulin human (as Insulin isophane human) 100 unit per
1mlInsuman Basal 100 units/ml suspension for injection 5 ml vials|
1 vialP£ 5. 61
Insuman Basal 100 units/ml suspension for injection 3 ml cartridges|
5 cartridgeP£ 17. 50 DT = £ 19. 08
▶Insuman Basal SoloStar(Sanofi)
Insulin human (as Insulin isophane human) 100 unit per
1mlInsuman Basal 100 units/ml suspension for injection 3 ml pre-
filled SoloStar pen| 5 pre-filled disposable injectionP£ 19. 80 DT
=£ 21. 70INSULINS›INTERMEDIATE-ACTING
COMBINED WITH RAPID-ACTING
eiiiiF 454Biphasic insulin aspart
(Intermediate-acting insulin)
lINDICATIONS AND DOSE
Diabetes mellitus
▶BY SUBCUTANEOUS INJECTION
▶Child:Administer up to 10 minutes before or soon after
a meal, according to requirementslINTERACTIONS→Appendix 1 : insulins
lPRESCRIBING AND DISPENSING INFORMATIONCheck
product container—the proportions of the two
components should be checked carefully (the order in
which the proportions are stated may not be the same in
other countries).lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Suspension for injection
▶NovoMix 30 FlexPen(Novo Nordisk Ltd)
Insulin aspart 30 unit per 1 ml, Insulin aspart (as Insulin aspart
protamine) 70 unit per 1 mlNovoMix 30 FlexPen 100 units/ml
suspension for injection 3 ml pre-filled pen| 5 pre-filled disposable
injectionP£ 29. 89 DT = £ 29. 89
▶NovoMix 30 Penfill(Novo Nordisk Ltd)
Insulin aspart 30 unit per 1 ml, Insulin aspart (as Insulin aspart
protamine) 70 unit per 1 mlNovoMix 30 Penfill 100 units/ml
suspension for injection 3 ml cartridges| 5 cartridgeP£ 28. 79 DT
=£ 28. 79eiiiiF 454Biphasic insulin lispro
(Intermediate-acting insulin)
lINDICATIONS AND DOSE
Diabetes mellitus
▶BY SUBCUTANEOUS INJECTION
▶Child:Administer up to 15 minutes before or soon after
a meal, according to requirementslCAUTIONSChildren under 12 years (use only if benefit
likely compared to soluble insulin)
lINTERACTIONS→Appendix 1 : insulins
lPRESCRIBING AND DISPENSING INFORMATIONCheck
product container—the proportions of the two
components should be checked carefully (the order in
which the proportions are stated may not be the same in
other countries).lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Suspension for injection
▶Humalog Mix 25 (Eli Lilly and Company Ltd)
Insulin lispro 25 unit per 1 ml, Insulin lispro (as Insulin lispro
protamine) 75 unit per 1 mlHumalog Mix25 100units/ml suspension
for injection 10 ml vials| 1 vialP£ 16. 61
Humalog Mix25 100units/ml suspension for injection 3 ml cartridges|
5 cartridgeP£ 29. 46 DT = £ 29. 46
▶Humalog Mix 25 KwikPen(Eli Lilly and Company Ltd)
Insulin lispro 25 unit per 1 ml, Insulin lispro (as Insulin lispro
protamine) 75 unit per 1 mlHumalog Mix 25 KwikPen 100 units/ml
suspension for injection 3 ml pre-filled pen| 5 pre-filled disposable
injectionP£ 30. 98 DT = £ 30. 98
▶Humalog Mix 50 (Eli Lilly and Company Ltd)
Insulin lispro 50 unit per 1 ml, Insulin lispro (as Insulin lispro
protamine) 50 unit per 1 mlHumalog Mix50 100units/ml
suspension for injection 3 ml cartridges| 5 cartridgeP£ 29. 46 DT
=£ 29. 46
▶Humalog Mix 50 KwikPen(Eli Lilly and Company Ltd)
Insulin lispro 50 unit per 1 ml, Insulin lispro (as Insulin lispro
protamine) 50 unit per 1 mlHumalog Mix 50 KwikPen 100 units/ml
suspension for injection 3 ml pre-filled pen| 5 pre-filled disposable
injectionP£ 30. 98 DT = £ 30. 98INSULINS›LONG-ACTING
eiiiiF 454Insulin degludec 14-Mar-2017
(Recombinant human insulin analogue—long
acting)lINDICATIONS AND DOSE
Diabetes mellitus
▶BY SUBCUTANEOUS INJECTION
▶Child 1–17 years:Dose to be given according to
requirementslINTERACTIONS→Appendix 1 : insulins
lSIDE-EFFECTS
▶UncommonPeripheral oedema
lPREGNANCYEvidence of the safety of long-acting insulin
analogues in pregnancy is limited, therefore isophane
insulin is recommended where longer-acting insulins are
needed; insulin detemir may also be considered.
lPRESCRIBING AND DISPENSING INFORMATIONInsulin
degludec (Tresiba®) is available in strengths of
100 units/mL (allows 1 -unit dose adjustment) and
200 units/mL (allows 2 -unit dose adjustment)—ensure
correct strength prescribed.458 Diabetes mellitus and hypoglycaemia BNFC 2018 – 2019
Endocrine system6