Tamsulosin hydrochloride
lINDICATIONS AND DOSE
Dysfunctional voiding (administered on expert advice)
▶BY MOUTH USING MODIFIED-RELEASE MEDICINES
▶Child 12–17 years: 400 micrograms once dailylUNLICENSED USENot licensed for use in children.
lCONTRA-INDICATIONSHistory of postural hypotension
lCAUTIONSCare with initial dose (postural hypotension).
cataract surgery (risk of intra-operativefloppy iris
syndrome)
lINTERACTIONS→Appendix 1 : alpha blockers
lSIDE-EFFECTS
▶Common or very commonDizziness.sexual dysfunction
▶UncommonAsthenia.constipation.diarrhoea.headache.
nausea.palpitations.postural hypotension.rhinitis.skin
reactions.vomiting
▶Rare or very rareAngioedema.Stevens-Johnson syndrome
.syncope
▶Frequency not knownDry mouth.epistaxis.vision
disorders
lHEPATIC IMPAIRMENTAvoid in severe impairment.
lRENAL IMPAIRMENTUse with caution if estimated
glomerularfiltration rate less than 10 mL/minute/ 1. 73 m^2.
lPATIENT AND CARER ADVICE
Driving and skilled tasksMay affect performance of skilled
tasks e.g. driving.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Modified-release tablet
CAUTIONARY AND ADVISORY LABELS 25
▶Tamsulosin hydrochloride (Non-proprietary)
Tamsulosin hydrochloride 400 microgramTamsulosin
400 microgram modified-release tablets| 30 tabletP£ 10. 47 DT =
£ 10. 47
▶Cositam XL(Consilient Health Ltd)
Tamsulosin hydrochloride 400 microgramCositam XL
400 microgram tablets| 30 tabletP£ 8. 89 DT = £ 10. 47
▶Faramsil(Sandoz Ltd)
Tamsulosin hydrochloride 400 microgramFaramsil
400 microgram modified-release tablets| 30 tabletP£ 8. 89 DT =
£ 10. 47
▶Flectone XL(Teva UK Ltd)
Tamsulosin hydrochloride 400 microgramFlectone XL
400 microgram tablets| 30 tabletP£ 9. 95 DT = £ 10. 47
▶Flomaxtra XL(Astellas Pharma Ltd)
Tamsulosin hydrochloride 400 microgramFlomaxtra XL
400 microgram tablets| 30 tabletP£ 10. 47 DT = £ 10. 47
Modified-release capsule
CAUTIONARY AND ADVISORY LABELS 25
▶Tamsulosin hydrochloride (Non-proprietary)
Tamsulosin hydrochloride 400 microgramTamsulosin
400 microgram modified-release capsules| 30 capsuleP£ 5. 07 DT
=£ 3. 87
▶Contiflo XL(Ranbaxy (UK) Ltd)
Tamsulosin hydrochloride 400 microgramContiflo XL
400 microgram capsules| 30 capsuleP£ 7. 44 DT = £ 3. 87
▶Diffundox XL(Zentiva)
Tamsulosin hydrochloride 400 microgramDiffundox XL
400 microgram capsules| 30 capsuleP£ 9. 55 DT = £ 3. 87
▶Flomax MR(Sanofi)
Tamsulosin hydrochloride 400 microgramFlomax Relief MR
400 microgram capsules| 14 capsulep£ 5. 58 | 28 capsulep
£ 10. 55
▶Pamsvax XL(Almus Pharmaceuticals Ltd, Actavis UK Ltd)
Tamsulosin hydrochloride 400 microgramPamsvax XL
400 microgram capsules| 30 capsuleP£ 1. 28 DT = £ 3. 87
▶Petyme MR(Teva UK Ltd)
Tamsulosin hydrochloride 400 microgramPetyme 400 microgram
MR capsules| 30 capsuleP£ 4. 06 DT = £ 3. 87▶Pinexel PR(Wockhardt UK Ltd)
Tamsulosin hydrochloride 400 microgramPinexel PR
400 microgram capsules| 30 capsuleP£ 2. 50 DT = £ 3. 87
▶Prosurin XL(Mylan)
Tamsulosin hydrochloride 400 microgramProsurin XL
400 microgram capsules| 30 capsuleP£ 4. 28 DT = £ 3. 87
▶Tabphyn MR(Thornton & Ross Ltd)
Tamsulosin hydrochloride 400 microgramTabphyn MR
400 microgram capsules| 30 capsuleP£ 4. 45 DT = £ 3. 87
▶Tamfrex XL(Milpharm Ltd)
Tamsulosin hydrochloride 400 microgramTamfrex XL
400 microgram capsules| 30 capsuleP£ 3. 87 DT = £ 3. 87
▶Tamurex(Somex Pharma)
Tamsulosin hydrochloride 400 microgramTamurex
400 microgram modified-release capsules| 30 capsuleP£ 3. 50 DT
=£ 3. 871.3 Urological pain
Urological pain
Treatment
Lidocaine hydrochloride gelis a useful topical application
inurethral painor to relieve the discomfort of
catheterisation.Alkalinisation of urine
Alkalinisationof urine can be undertaken with potassium
citrate. The alkalinising action may relieve the discomfort of
cystitiscaused by lower urinary tract infections.ALKALISING DRUGS
Citric acid with potassium citrate
lINDICATIONS AND DOSE
Relief of discomfort in mild urinary-tract infections|
Alkalinisation of urine
▶BY MOUTH USING ORAL SOLUTION
▶Child 1–5 years: 5 mL 3 times a day, diluted well with
water
▶Child 6–17 years: 10 mL 3 times a day, diluted well with
waterlCAUTIONSCardiac disease
lINTERACTIONS→Appendix 1 : potassium citrate
lSIDE-EFFECTSHyperkalaemia.nausea.vomiting
lRENAL IMPAIRMENTAvoid in severe impairment.
MonitoringClose monitoring required in renal
impairment—high risk of hyperkalaemia.
lPRESCRIBING AND DISPENSING INFORMATIONWhen
prepared extemporaneously, the BP states Potassium
Citrate Mixture BP consists of potassium citrate 30 %, citric
acid monohydrate 5 % in a suitable vehicle with a lemon
flavour. Extemporaneous preparations should be recently
prepared according to the following formula: potassium
citrate 3 g, citric acid monohydrate 500 mg, syrup 2. 5 mL,
quillaia tincture 0. 1 mL, lemon spirit 0. 05 mL, double-
strength chloroform water 3 mL, water to 10 mL. Contains
about 28 mmol K+/ 10 mL.
lEXCEPTIONS TO LEGAL CATEGORYProprietary brands of
potassium citrate are on sale to the public for the relief of
discomfort in mild urinary-tract infections.492 Bladder and urinary disorders BNFC 2018 – 2019
Genito-urinary system7