.If ring expelled during week 1 or 2 of cycle, rinse ring
with cool water and reinsert; use additional precautions
(barrier methods) for next 7 days;
.If ring expelled during week^3 of cycle, either insert a
new ring to start a new cycleorallow a withdrawal bleed
and insert a new ring no later than 7 days after ring was
expelled; latter option only available if ring was used
continuously for at least 7 days before expulsion.
If insertion of a new ring at the start of a new cycle is
delayed, contraceptive protection is lost. A new ring
should be inserted as soon as possible; additional
precautions (barrier methods) should be used for thefirst
7 days of the new cycle. If intercourse occurred during the
extended ring-free interval, pregnancy should be
considered.
No additional contraception is required if removal of the
ring is delayed by up to 1 week ( 4 weeks of continuous
use). The 7 -day ring-free interval should be observed and
subsequently a new ring should be inserted. Contraceptive
protection may be reduced with continuous use of the ring
for more than 4 weeks—pregnancy should be ruled out
before inserting a new ring.
If the ring breaks during use, remove it and insert a new
ring immediately; additional precautions (barrier
methods) should be used for thefirst 7 days of the new
cycle.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Vaginal delivery system
▶Ethinylestradiol with etonogestrel (Non-proprietary)
Ethinylestradiol 2.7 mg, Etonogestrel 11.7 mgEthinylestradiol
2. 7 mg / Etonogestrel 11. 7 mg vaginal delivery system|
3 systemPsDT = £ 29. 70
▶NuvaRing(Merck Sharp & Dohme Ltd)
Ethinylestradiol 2.7 mg, Etonogestrel 11.7 mgNuvaRing
0. 12 mg/ 0. 015 mg per day vaginal delivery system| 3 systemP
£ 29. 70 DT = £ 29. 70
eiiiiF 498Ethinylestradiol with gestodene
lINDICATIONS AND DOSE
Contraception with 21 -day combined preparations|
Menstrual symptoms with 21 -day combined
preparations
▶BY MOUTH
▶Females of childbearing potential: 1 tablet once daily for
21 days; subsequent courses repeated after 7 -day
interval, withdrawal bleeding occurs during the 7 -day
interval, if reasonably certain woman is not pregnant,
first course can be started on any day of cycle—if
starting on day 6 of cycle or later, additional
precautions (barrier methods) necessary duringfirst
7 days, tablets should be taken at approximately the
same time each day
Contraception with 28 -day combined preparations|
Menstrual symptoms with 28 -day combined
preparations
▶BY MOUTH
▶Females of childbearing potential: 1 active tablet once
daily for 21 days, followed by 1 inactive tablet daily for
7 days; subsequent courses repeated without interval,
withdrawal bleeding occurs during the 7 -day interval of
inactivetablets being taken, if reasonably certain
woman is not pregnant,first course can be started on
any day of cycle—if starting on day 6 of cycle or later,
additional precautions (barrier methods) necessary
duringfirst 7 days, tablets should be taken at
approximately the same time each daylUNLICENSED USEConsult product literature for the
licensing status.
lINTERACTIONS→Appendix 1 : combined hormonal
contraceptives
lSIDE-EFFECTS
▶Common or very commonAbdominal pain.breast
abnormalities.depression.dizziness.increased risk of
infection.mood swings.nervousness.vaginal discharge
▶UncommonAppetite abnormal.diarrhoea.hirsutism.
hypertriglyceridaemia.sexual dysfunction.skin reactions
.vomiting
▶Rare or very rareAngioedema.chorea exacerbated.ear
disorders.embolism and thrombosis.erythema nodosum.
eye irritation.gallbladder disorders.gastrointestinal
disorders.haemolytic uraemic syndrome.hepatic
disorders.hypersensitivity.inflammatory bowel disease.
neoplasms.optic neuritis.pancreatitis.systemic lupus
erythematosus exacerbated.varicose veins exacerbated.
weight decreasedlMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Tablet
▶Ethinylestradiol with gestodene (Non-proprietary)
Ethinylestradiol 30 microgram, Gestodene
50 microgramEthinylestradiol 30 microgram / Gestodene
50 microgram tablets| 18 tabletPs
Ethinylestradiol 40 microgram, Gestodene
70 microgramEthinylestradiol 40 microgram / Gestodene
70 microgram tablets| 15 tabletPs
Ethinylestradiol 20 microgram, Gestodene
75 microgramEthinylestradiol 20 microgram / Gestodene
75 microgram tablets| 63 tabletPsDT = £ 8. 85
Ethinylestradiol 30 microgram, Gestodene
75 microgramEthinylestradiol 30 microgram / Gestodene
75 microgram tablets| 63 tabletPsDT = £ 6. 73
Ethinylestradiol 30 microgram, Gestodene
100 microgramEthinylestradiol 30 microgram / Gestodene
100 microgram tablets| 30 tabletPs
▶Aidulan(Lupin Healthcare (UK) Ltd)
Ethinylestradiol 30 microgram, Gestodene 75 microgramAidulan
30 microgram/ 75 microgram tablets| 63 tabletP£ 4. 11 DT = £ 6. 73
Ethinylestradiol 20 microgram, Gestodene 75 microgramAidulan
20 microgram/ 75 microgram tablets| 63 tabletP£ 5. 40 DT = £ 8. 85
▶Femodene(Bayer Plc)
Ethinylestradiol 30 microgram, Gestodene
75 microgramFemodene tablets| 63 tabletP£ 6. 73 DT = £ 6. 73
▶Femodette(Bayer Plc)
Ethinylestradiol 20 microgram, Gestodene
75 microgramFemodette tablets| 63 tabletP£ 8. 85 DT = £ 8. 85
▶Juliperla(Actavis UK Ltd)
Ethinylestradiol 20 microgram, Gestodene
75 microgramJuliperla 75 microgram/ 20 microgram tablets|
63 tabletP£ 5. 41 DT = £ 8. 85
▶Katya(Stragen UK Ltd)
Ethinylestradiol 30 microgram, Gestodene 75 microgramKatya
30 / 75 tablets| 63 tabletP£ 5. 03 DT = £ 6. 73
▶Millinette(Consilient Health Ltd)
Ethinylestradiol 30 microgram, Gestodene
75 microgramMillinette 30 microgram/ 75 microgram tablets|
63 tabletP£ 4. 12 DT = £ 6. 73
Ethinylestradiol 20 microgram, Gestodene
75 microgramMillinette 20 microgram/ 75 microgram tablets|
63 tabletP£ 5. 41 DT = £ 8. 85
▶Sofiperla(Actavis UK Ltd)
Ethinylestradiol 30 microgram, Gestodene
75 microgramSofiperla 75 microgram/ 30 microgram tablets|
63 tabletP£ 4. 12 DT = £ 6. 73
▶Sunya(Stragen UK Ltd)
Ethinylestradiol 20 microgram, Gestodene 75 microgramSunya
20 / 75 tablets| 63 tabletP£ 4. 86 DT = £ 8. 85502 Contraception BNFC 2018 – 2019
Genito-urinary system7