lCAUTIONSAvoid intravaginal preparations (particularly
those that require use of an applicator) in young girls who
are not sexually active, unless there is no alternative
lSIDE-EFFECTS
▶Common or very commonSkin reactions
▶UncommonVaginal burning
▶Frequency not knownAngioedema
lCONCEPTION AND CONTRACEPTIONCream and pessaries
damage latex condoms and diaphragms.
lPREGNANCYPregnant women need a longer duration of
treatment, usually about 7 days, to clear the infection.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Pessary
▶Gyno-Pevaryl(Janssen-Cilag Ltd)
Econazole nitrate 150 mgGyno-Pevaryl Once 150 mg vaginal
pessary| 1 pessaryP£ 3. 69
Gyno-Pevaryl 150 mg vaginal pessaries| 3 pessaryP£ 4. 17Fenticonazole nitrate
lINDICATIONS AND DOSE
Vaginal and vulva candidiasis
▶BY VAGINA USING CAPSULES
▶Child: 200 mg daily for 3 days, alternatively 600 mg
daily for 1 dose, to be inserted at night
▶BY VAGINA USING CREAM
▶Child: 1 applicatorful twice daily for 3 days
DOSE EQUIVALENCE AND CONVERSION
▶ 1 applicatorful delivers a 5 g dose of fenticonazole 2 %.lCAUTIONSAvoid intravaginal preparations (particularly
those that require use of an applicator) in young girls who
are not sexually active, unless there is no alternative
lSIDE-EFFECTSParaesthesia
lCONCEPTION AND CONTRACEPTIONIntravaginal cream and
vaginal capsules damage latex condoms and diaphragms.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Cream
EXCIPIENTS:May contain Cetostearyl alcohol (including cetyl and
stearyl alcohol), propylene glycol, woolfat and related substances
(including lanolin)
▶Gynoxin(Recordati Pharmaceuticals Ltd)
Fenticonazole nitrate 20 mg per 1 gramGynoxin 2 % vaginal cream
| 30 gramP£ 3. 74
Capsule
EXCIPIENTS:May contain Hydroxybenzoates (parabens)
▶Gynoxin(Recordati Pharmaceuticals Ltd)
Fenticonazole nitrate 200 mgGynoxin 200 mg vaginal capsules|
3 capsuleP£ 2. 42
Fenticonazole nitrate 600 mgGynoxin 600 mg vaginal capsules|
1 capsuleP£ 2. 62Miconazole 11-Oct-2017
lINDICATIONS AND DOSE
Vaginal and vulval candidiasis
▶BY VAGINA USING CAPSULES
▶Child: 1 capsule daily, ovule to be inserted at night as a
single dose, dose can be repeated once if necessarylCAUTIONS
GENERAL CAUTIONSAvoid in Acute porphyrias p. 603.
avoid intravaginal preparations (particularly those that
require use of an applicator) in young girls who are not
sexually active, unless there is no alternativelINTERACTIONS→Appendix 1 : antifungals, azoles
lSIDE-EFFECTS
▶UncommonSkin reactions
▶Frequency not knownAngioedema
lCONCEPTION AND CONTRACEPTIONGyno-Daktarin®
damages latex condoms and diaphragms.
lPREGNANCYPregnant women need a longer duration of
treatment, usually about 7 days, to clear the infection.
lBREAST FEEDINGManufacturer advises caution—no
information available.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Capsule
EXCIPIENTS:May contain hydroxybenzoates (parabens)
▶Gyno-Daktarin(Janssen-Cilag Ltd)
Miconazole nitrate 1.2 gramGyno-Daktarin 1200 mg vaginal
capsules| 1 capsuleP£ 2. 94 DT price = £ 2. 94516 Vaginal and vulval conditions BNFC 2018 – 2019
Genito-urinary system7