Prophylaxis of graft rejection following kidney
transplantation, starting within 24 hours of
transplantation
▶BY MOUTH
▶Neonate:Initially 150 micrograms/kg twice daily.
▶Child:Initially 150 micrograms/kg twice daily, a lower
initial dose of 100 micrograms/kg twice daily has been
used in adolescents to prevent very high‘trough’
concentrations
Prophylaxis of graft rejection following heart
transplantation following antibody induction, starting
within 5 days of transplantation
▶BY MOUTH
▶Neonate:Initially 50 – 150 micrograms/kg twice daily.
▶Child:Initially 50 – 150 micrograms/kg twice daily
Prophylaxis of graft rejection following heart
transplantation without antibody induction, starting
within 12 hours of transplantation
▶BY MOUTH
▶Neonate:Initially 150 micrograms/kg twice daily, dose to
be given as soon as clinically possible ( 8 – 12 hours after
discontinuation of intravenous infusion).
▶Child:Initially 150 micrograms/kg twice daily, dose to
be given as soon as clinically possible ( 8 – 12 hours after
discontinuation of intravenous infusion)
Allograft rejection resistant to conventional
immunosuppressive therapy
▶BY MOUTH
▶Child:Seek specialist advice
PROGRAF®CAPSULES
Prophylaxis of graft rejection following liver
transplantation, starting 12 hours after transplantation
▶BY MOUTH
▶Neonate:Initially 150 micrograms/kg twice daily.
▶Child:Initially 150 micrograms/kg twice daily
Prophylaxis of graft rejection following kidney
transplantation, starting within 24 hours of
transplantation
▶BY MOUTH
▶Neonate:Initially 150 micrograms/kg twice daily.
▶Child:Initially 150 micrograms/kg twice daily, a lower
initial dose of 100 micrograms/kg twice daily has been
used in adolescents to prevent very high‘trough’
concentrations
Prophylaxis of graft rejection following heart
transplantation following antibody induction, starting
within 5 days of transplantation
▶BY MOUTH
▶Neonate:Initially 50 – 150 micrograms/kg twice daily.
▶Child:Initially 50 – 150 micrograms/kg twice daily
Prophylaxis of graft rejection following heart
transplantation without antibody induction, starting
within 12 hours of transplantation
▶BY MOUTH
▶Neonate:Initially 150 micrograms/kg twice daily, dose to
be given as soon as clinically possible ( 8 – 12 hours after
discontinuation of intravenous infusion).
▶Child:Initially 150 micrograms/kg twice daily, dose to
be given as soon as clinically possible ( 8 – 12 hours after
discontinuation of intravenous infusion)
Allograft rejection resistant to conventional
immunosuppressive therapy
▶BY MOUTH
▶Child:Seek specialist advice
PROGRAF®INFUSION
Prophylaxis of graft rejection following liver
transplantation, starting 12 hours after transplantation
when oral route not appropriate
▶BY CONTINUOUS INTRAVENOUS INFUSION
▶Neonate:Initially 50 micrograms/kg daily for up to
7 days (then transfer to oral therapy), dose to be
administered over 24 hours.▶Child:Initially 50 micrograms/kg daily for up to 7 days
(then transfer to oral therapy), dose to be administered
over 24 hours
Prophylaxis of graft rejection following kidney
transplantation, starting within 24 hours of
transplantation when oral route not appropriate
▶BY CONTINUOUS INTRAVENOUS INFUSION
▶Neonate:Initially 75 – 100 micrograms/kg daily for up to
7 days (then transfer to oral therapy), dose to be
administered over 24 hours.▶Child:Initially 75 – 100 micrograms/kg daily for up to
7 days (then transfer to oral therapy), dose to be
administered over 24 hours
Prophylaxis of graft rejection following heart
transplantation without antibody induction, starting
within 12 hours of transplantation
▶BY CONTINUOUS INTRAVENOUS INFUSION
▶Neonate:Initially 30 – 50 micrograms/kg daily for up to
7 days (then transfer to oral therapy), dose to be
administered over 24 hours.▶Child:Initially 30 – 50 micrograms/kg daily for up to
7 days (then transfer to oral therapy), dose to be
administered over 24 hours
Allograft rejection resistant to conventional
immunosuppressive therapy
▶BY CONTINUOUS INTRAVENOUS INFUSION
▶Child:Seek specialist advice (consult local protocol)
TACNI®
Prophylaxis of graft rejection following liver
transplantation, starting 12 hours after transplantation
▶BY MOUTH
▶Neonate:Initially 150 micrograms/kg twice daily.▶Child:Initially 150 micrograms/kg twice daily
Prophylaxis of graft rejection following kidney
transplantation, starting within 24 hours of
transplantation
▶BY MOUTH
▶Neonate:Initially 150 micrograms/kg twice daily.▶Child:Initially 150 micrograms/kg twice daily, a lower
initial dose of 100 micrograms/kg twice daily has been
used in adolescents to prevent very high‘trough’
concentrations
Prophylaxis of graft rejection following heart
transplantation following antibody induction, starting
within 5 days of transplantation
▶BY MOUTH
▶Neonate:Initially 50 – 150 micrograms/kg twice daily.▶Child:Initially 50 – 150 micrograms/kg twice
daily continued→BNFC 2018 – 2019 Immune system disorders and transplantation 523
Immune system and malignant disease8