lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: capsule, oral suspension, oral solution,
solution for injection
Tablet
▶Pyridoxine hydrochloride (Non-proprietary)
Pyridoxine hydrochloride 10 mgPyridoxine 10 mg tablets|
28 tablet £ 12. 95 DT = £ 12. 95 | 28 tabletP£ 16. 95 DT = £ 12. 95
Pyridoxine hydrochloride 20 mgPyridoxine 20 mg tablets|
500 tabletGs
Pyridoxine hydrochloride 50 mgPyridoxine 50 mg tablets|
28 tabletpsDT = £ 12. 00
Solution for injection
▶Pyridoxine hydrochloride (Non-proprietary)
Pyridoxine hydrochloride 25 mg per 1 mlSicovit B 650 mg/ 2 ml
solution for injection vials| 5 vialPs
Pyridoxine hydrochloride 50 mg per 1 mlVitamin B 6 Streuli
100 mg/ 2 ml solution for injection ampoules| 10 ampoulePs
Capsule
▶Pyridoxine hydrochloride (Non-proprietary)
Pyridoxine hydrochloride 100 mgVitamin B6 100mg capsules|
120 capsule £ 6. 00Riboflavin
(Riboflavine; Vitamin B 2 )
lINDICATIONS AND DOSE
Metabolic diseases
▶BY MOUTH
▶Neonate: 50 mg 1 – 2 times a day, adjusted according to
response.▶Child: 50 – 100 mg 1 – 2 times a day, adjusted according
to response to up to 400 mg dailylUNLICENSED USENot licensed in children.
lSIDE-EFFECTSUrine discolouration
lPREGNANCYCrosses the placenta but no adverse effects
reported, information at high doses limited.
lBREAST FEEDINGPresent in breast milk but no adverse
effects reported, information at high doses limited.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: tablet, modified-release tablet, capsule,
oral suspension, oral solution
Modified-release tablet
▶Riboflavin (Non-proprietary)
Riboflavin 100 mgVitamin B2 100mg modified-release tablets|
60 tablet £ 4. 46
Capsule
▶Riboflavin (Non-proprietary)
Riboflavin 50 mgRiboflavin 50 mg capsules| 30 capsule £ 3. 13
▶B- 2 - 50 (Bio-Tech Pharmacal Inc)
Riboflavin 50 mgB- 2 - 50 capsules| 100 capsules
▶E-B 2 (Ennogen Healthcare Ltd)
Riboflavin 50 mgE-B 250 mg capsules| 30 capsule £ 84. 70
Riboflavin 100 mgE-B2 100mg capsules| 30 capsule £ 89. 20Thiamine
(Vitamin B 1 )
lINDICATIONS AND DOSE
Maple syrup urine disease
▶BY MOUTH
▶Neonate: 5 mg/kg daily, dose to be adjusted as necessary.▶Child: 5 mg/kg daily, dose to be adjusted as necessaryMetabolic disorders|Congenital lactic acidosis
▶INITIALLY BY MOUTH, OR BY INTRAVENOUS INFUSION
▶Neonate: 50 – 200 mg once daily, dose to be adjusted as
necessary, the total dose may alternatively be given in
2 – 3 divided doses, administer intravenous infusion over
30 minutes.▶Child: 100 – 300 mg once daily, dose to be adjusted as
necessary, the total dose may alternatively be given in
2 – 3 divided doses, administer intravenous infusion
over 30 minutes, (by mouth) increased if necessary up
to 2 g dailylUNLICENSED USENot licensed in children.IMPORTANT SAFETY INFORMATION
MHRA/CHM ADVICE (SEPTEMBER 2007)
Although potentially serious allergic adverse reactions
may rarely occur during, or shortly after, parenteral
administration, the CHM has recommended that:
.This should not preclude the use of parenteral
thiamine in patients where this route of
administration is required, particularly in patients at
risk of Wernicke-Korsakoff syndrome where treatment
with thiamine is essential;
.Intravenous administration should be by infusion over
30 minutes;
.Facilities for treating anaphylaxis (including
resuscitation facilities) should be available when
parenteral thiamine is administered.lCAUTIONSAnaphylaxis may occasionally follow injection
lSIDE-EFFECTSAbdominal pain.diarrhoea.
gastrointestinal disorder.nausea.palpitations.
respiratory distress.shock.skin reactions.tachycardia.
vomiting
lBREAST FEEDINGSeverely thiamine-deficient mothers
should avoid breast-feeding as toxic methyl-glyoxal
present in milk.
lPRESCRIBING AND DISPENSING INFORMATION
▶With intravenous useSome preparations may contain phenol
as a preservative.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension, oral solution
Modified-release tablet
▶Thiamine (Non-proprietary)
Thiamine hydrochloride 100 mgVitamin B1 100mg modified-
release tablets| 90 tablet £ 4. 46
Tablet
▶Thiamine (Non-proprietary)
Thiamine hydrochloride 25 mgVitamin B 125 mg tablets|
100 tabletps
Thiamine hydrochloride 50 mgThiamine 50 mg tablets|
28 tabletp£ 1. 32 – £ 1. 80 | 100 tabletsDT = £ 4. 72 | 100 tabletp
£ 6. 72 DT = £ 4. 72
Thiamine hydrochloride 100 mgThiamine 100 mg tablets|
28 tabletp£ 1. 91 – £ 6. 72 | 100 tabletp£ 11. 55 DT = £ 6. 83 |
100 tabletsDT = £ 6. 83
▶Benerva(Teofarma)
Thiamine hydrochloride 50 mgBenerva 50 mg tablets|
100 tabletp£ 4. 00 DT = £ 4. 72
Thiamine hydrochloride 100 mgBenerva 100 mg tablets|
100 tabletp£ 6. 29 DT = £ 6. 83
▶Tyvera(Auden McKenzie (Pharma Division) Ltd)
Thiamine hydrochloride 100 mgTyvera 100 mg tablets|
100 tabletp£ 6. 99 DT = £ 6. 83
Solution for injection
▶Thiamine (Imported)
Thiamine hydrochloride 50 mg per 1 mlBevitine 100 mg/ 2 ml
solution for injection ampoules| 5 ampoulePs
Thiamine hydrochloride 100 mg per 1 mlVitamin B 1 Streuli
100 mg/ 1 ml solution for injection ampoules| 10 ampoulePs628 Vitamin deficiency BNFC 2018 – 2019
Blood and nutrition9