Oral drops
EXCIPIENTS:May contain Alcohol
▶One-Alpha(LEO Pharma)
Alfacalcidol 2 microgram per 1 mlOne-Alpha 2 micrograms/ml oral
drops sugar-free| 10 mlP£ 21. 30 DT = £ 21. 30
Capsule
EXCIPIENTS:May contain Sesame oil
▶Alfacalcidol (Non-proprietary)
Alfacalcidol 250 nanogramAlfacalcidol 250 nanogram capsules|
30 capsuleP£ 5. 00 DT = £ 4. 82
Alfacalcidol 500 nanogramAlfacalcidol 500 nanogram capsules|
30 capsuleP£ 10. 00 DT = £ 9. 68
Alfacalcidol 1 microgramAlfacalcidol 1 microgram capsules|
30 capsuleP£ 14. 00 DT = £ 13. 49 | 30 capsulesDT = £ 13. 49
▶One-Alpha(LEO Pharma)
Alfacalcidol 250 nanogramOne-Alpha 250 nanogram capsules|
30 capsuleP£ 3. 37 DT = £ 4. 82
Alfacalcidol 500 nanogramOne-Alpha 0. 5 microgram capsules|
30 capsuleP£ 6. 27 DT = £ 9. 68
Alfacalcidol 1 microgramOne-Alpha 1 microgram capsules|
30 capsuleP£ 8. 75 DT = £ 13. 49
eiiiiF 630Calcitriol
(1,25-Dihydroxycholecalciferol)
lINDICATIONS AND DOSE
Vitamin D dependent rickets|Hypophosphataemic rickets
|Persistent hypocalcaemia due to hypoparathyroidism|
Pseudo-hypoparathyroidism (limited experience)
▶BY MOUTH
▶Child 1 month–11 years:Initially 15 nanograms/kg once
daily (max. per dose 250 nanograms), increased in
steps of 5 nanograms/kg daily (max. per dose
250 nanograms) if required, dose to be increased every
2 – 4 weeks
▶Child 12–17 years:Initially 250 nanograms once daily,
increased in steps of 5 nanograms/kg daily (max. per
dose^250 nanograms) if required, dose to be increased
every 2 – 4 weeks; usual dose 0. 5 – 1 microgram dailylUNLICENSED USENot licensed for use in children.
lCAUTIONSTake care to ensure correct dose in infants
lINTERACTIONS→Appendix 1 : vitamin D substances
lSIDE-EFFECTS
▶Common or very commonUrinary tract infection
▶Frequency not knownApathy.arrhythmia.dehydration.
drowsiness.fever.growth retardation.muscle weakness.
paralytic ileus.polydipsia.psychiatric disorder.sensory
disorder.urinary disorders.weight decreased
lHEPATIC IMPAIRMENTManufacturer advises avoid—no
information available.
lRENAL IMPAIRMENTManufacturer advises avoid—no
information available.
MonitoringMonitor plasma-calcium concentration in
renal impairment.
lMONITORING REQUIREMENTS
▶Monitor plasma calcium, phosphate, and creatinine during
dosage titration.
▶Monitor plasma-calcium concentration in patients
receiving high doses.
lDIRECTIONS FOR ADMINISTRATIONContents of capsule
may be administered by oral syringe.
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension, oral solution
Capsule
▶Calcitriol (Non-proprietary)
Calcitriol 250 nanogramCalcitriol 250 nanogram capsules|
30 capsuleP£ 5. 41 – £ 18. 04 | 100 capsulePsDT = £ 18. 04
Calcitriol 500 nanogramCalcitriol 500 nanogram capsules|
30 capsuleP£ 9. 68 – £ 32. 25 | 100 capsulePsDT = £ 32. 25
▶Rocaltrol(Roche Products Ltd)
Calcitriol 250 nanogramRocaltrol 250 nanogram capsules|
100 capsuleP£ 18. 04 DT = £ 18. 04
Calcitriol 500 nanogramRocaltrol 500 nanogram capsules|
100 capsuleP£ 32. 25 DT = £ 32. 25eiiiiF 630Colecalciferol
(Cholecalciferol; Vitamin D 3 )
lINDICATIONS AND DOSE
Prevention of vitamin D deficiency
▶BY MOUTH
▶Child: 400 units dailylUNLICENSED USEAdcal-D 3 ®,Calceos®, andFultium-D 3 ®
800 units andFultium-D 3 ® 20000 units are not licensed for
use in children under 12 years.Cacit®D 3 ,Calcichew-D 3 ®
Forte,Calcichew-D 3 ® 500 mg/ 400 unit, andKalcipos-D®
not licensed for use in children (age range not specified by
manufacturers).Accrete D 3 ®,Calfovit D 3 ®, andNatecal
D 3 ®not licensed for use in children under 18 years.
lCAUTIONSTake care to ensure correct dose in infants
lINTERACTIONS→Appendix 1 : vitamin D substances
lSIDE-EFFECTSLaryngeal oedema
lRENAL IMPAIRMENT
MonitoringMonitor plasma-calcium concentration in
renal impairment.
lMONITORING REQUIREMENTSMonitor plasma-calcium
concentration in patients receiving high doses.
lDIRECTIONS FOR ADMINISTRATION
INVITA D3®ORAL SOLUTIONMay be mixed with a small
amount of milk or cold or lukewarm food immediately
before administration.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: tablet, capsule, oral suspension, oral
solution, oral drops
Tablet
▶Colecalciferol (Non-proprietary)
Colecalciferol 400 unitColecalciferol 400 unit tablets| 60 tablet
£ 15. 50
Colecalciferol 800 unitColecalciferol 800 unit tablets|
30 tabletP£ 3. 60 DT = £ 3. 60
Colecalciferol 5000 unitD 35 , 000 unit tablets| 60 tablet £ 5. 00
Colecalciferol 10000 unitColecalciferol 10 , 000 unit tablets|
30 tablet £ 36. 00
Colecalciferol 20000 unitColecalciferol 20 , 000 unit tablets|
20 tablet £ 36. 00
▶Aciferol D 3 (Rhodes Pharma Ltd)
Colecalciferol 400 unitAciferol D3 400unit tablets| 90 tablet £ 9. 99
Colecalciferol 2200 unitAciferol D 32 , 200 unit tablets| 90 tablet
£ 25. 99
Colecalciferol 3000 unitAciferol D 33 , 000 unit tablets| 60 tablet
£ 14. 99
Colecalciferol 5000 unitAciferol D 35 , 000 unit tablets| 60 tablet
£ 19. 99
Colecalciferol 10000 unitAciferol D 310 , 000 unit tablets| 30 tablet
£ 13. 99
Colecalciferol 20000 unitAciferol D 320 , 000 unit tablets| 30 tablet
£ 18. 99
▶Cubicole D 3 (Cubic Pharmaceuticals Ltd)
Colecalciferol 400 unitCubicole D3 400unit tablets| 30 tablet
£ 5. 95
▶Desunin(Meda Pharmaceuticals Ltd)
Colecalciferol 800 unitDesunin 800 unit tablets| 30 tabletP
£ 3. 60 DT = £ 3. 60 | 90 tabletP£ 10. 17
Colecalciferol 4000 unitDesunin 4 , 000 unit tablets|
70 tabletP£ 15. 90 DT = £ 15. 90
▶E-D 3 (Ennogen Healthcare Ltd)
Colecalciferol 400 unitE-D3 400unit tablets| 30 tablet £ 78. 50BNFC 2018 – 2019 Vitamin deficiency 631
Blood and nutrition9