▶Ephynal(Imported (Italy))
Alpha tocopheryl acetate 100 mgEphynal 100 mg chewable tablets
| 30 tablets
Capsule
▶E-Caps(Ennogen Healthcare Ltd)
Alpha tocopherol 75 unitE-Caps 75 unit capsules| 100 capsule
£ 109. 50
Alpha tocopherol 100 unitE-Caps 100 unit capsules| 30 capsule
£ 84. 40
Alpha tocopherol 200 unitE-Caps 200 unit capsules| 30 capsule
£ 89. 50
Alpha tocopherol 400 unitE-Caps 400 unit capsules| 30 capsule
£ 128. 50
Alpha tocopherol 1000 unitE-Caps 1 , 000 unit capsules| 30 capsule
£ 130. 20
▶Vita-E(Typharm Ltd)
Alpha tocopherol 75 unitVita-E 75 unit capsules| 100 capsule £ 4. 35
Alpha tocopherol 200 unitVita-E 200 unit capsules| 30 capsule
£ 3. 35 | 100 capsule £ 10. 34
Alpha tocopherol 400 unitVita-E 400 unit capsules| 30 capsule
£ 5. 04 | 100 capsule £ 16. 44VITAMINS AND TRACE ELEMENTS›VITAMIN K
Menadiol sodium phosphate
lINDICATIONS AND DOSE
Supplementation in vitamin K malabsorption
▶BY MOUTH
▶Child 1–11 years: 5 – 10 mg daily, dose to be adjusted as
necessary
▶Child 12–17 years: 10 – 20 mg daily, dose to be adjusted as
necessarylCONTRA-INDICATIONSInfants.neonates
lCAUTIONSG 6 PD deficiency (risk of haemolysis).vitamin E
deficiency (risk of haemolysis)
lPREGNANCYAvoid in late pregnancy and labour unless
benefit outweighs risk of neonatal haemolytic anaemia,
hyperbilirubinaemia, and kernicterus in neonate.lMEDICINAL FORMS
Forms available from special-order manufacturers include:
tablet, oral suspension, oral solutionPhytomenadione
(Vitamin K 1 )
lINDICATIONS AND DOSE
Neonatal prophylaxis of vitamin-K deficiency bleeding
▶BY INTRAMUSCULAR INJECTION
▶Preterm neonate: 400 micrograms/kg (max. per dose
1 mg) for 1 dose, to be given at birth, the intravenous
route may be used in preterm neonates with very low
birth-weight if intramuscular injection is not possible,
however, it may not provide the prolonged protection of
the intramuscular injection, any neonate receiving
intravenous vitamin K should be given subsequent oral
doses.▶Neonate: 1 mg for 1 dose, to be given at birth.Neonatal prophylaxis of vitamin-K deficiency bleeding in
healthy babies who are not at particular risk of bleeding
disorders
▶BY MOUTH USING CAPSULES
▶Neonate: 1 mg for 1 dose at birth (to protect from the risk
of vitamin K deficiency bleeding in thefirst week).Neonatal prophylaxis of vitamin-K deficiency bleeding in
healthy babies who are not at particular risk of bleeding
disorders (exclusively breast-fed babies)
▶BY MOUTH USING CAPSULES
▶Neonate:Initially 1 mg for 1 dose at birth, then 1 mg
every week for 12 weeks.Neonatal hypoprothrombinaemia|Vitamin-K deficiency
bleeding
▶BY INTRAVENOUS INJECTION
▶Neonate: 1 mg every 8 hours if required.Neonatal biliary atresia and liver disease
▶BY MOUTH
▶Neonate: 1 mg daily.Reversal of coumarin anticoagulation when continued
anticoagulation required or if no significant bleeding—
seek specialist advice
▶BY INTRAVENOUS INJECTION
▶Child: 15 – 30 micrograms/kg (max. per dose 1 mg) for
1 dose, dose may be repeated as necessary
Reversal of coumarin anticoagulation when
anticoagulation not required or if significant bleeding—
seek specialist advice|Treatment of haemorrhage
associated with vitamin-K deficiency—seek specialist
advice
▶BY INTRAVENOUS INJECTION
▶Child: 250 – 300 micrograms/kg (max. per dose 10 mg)
for 1 dose
KONAKION®MM PAEDIATRIC
Neonatal prophylaxis of vitamin-K deficiency bleeding in
healthy babies who are not at risk of bleeding disorders
▶BY MOUTH
▶Neonate:Initially 2 mg for 1 dose at birth, then 2 mg
after 4 – 7 days.Neonatal prophylaxis of vitamin-K deficiency bleeding in
healthy babies who are not at risk of bleeding disorders
(exclusively breast fed babies)
▶BY MOUTH
▶Neonate:Initially 2 mg for 1 dose at birth, then 2 mg
after 4 – 7 days for a further 1 dose, then 2 mg for a
further 1 dose 1 month after birth.lCAUTIONSIntravenous injections should be given very
slowly—risk of vascular collapse
KONAKION®MM PAEDIATRICParenteral administration in
premature infant or neonate of less than 2. 5 kg (increased
risk of kernicterus)
lPREGNANCYUse if potential benefit outweighs risk.
lBREAST FEEDINGPresent in milk.
lHEPATIC IMPAIRMENT
KONAKION®MMCaution—glycocholic acid may displace
bilirubin.
lDIRECTIONS FOR ADMINISTRATION
▶With oral use in neonatesThe contents of one capsule should
be administered by cutting the narrow tubular tip off and
squeezing the liquid contents into the mouth; if the baby
spits out the dose or is sick within three hours of
administration a replacement dose should be given.
KONAKION®MM PAEDIATRICKonakion®MM Paediatric
may be administeredby mouthorby intramuscular injection
orby intravenous injection. Forintravenous injection, may be
diluted with Glucose 5 % if necessary.
KONAKION®MMKonakion®MMmay be administered by
slow intravenous injection or by intravenous infusion in
glucose 5 %;notfor intramuscular injection.636 Vitamin deficiency BNFC 2018 – 2019
Blood and nutrition9