lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: tablet, capsule, oral suspension, oral
solution
Tablet
▶Phytomenadione (Non-proprietary)
Phytomenadione 100 microgramVitamin K1 100microgram tablets
| 30 tablets
Solution for injection
EXCIPIENTS:May contain Glycocholic acid, lecithin
▶Konakion MM(Roche Products Ltd)
Phytomenadione 10 mg per 1 mlKonakion MM Paediatric
2 mg/ 0. 2 ml solution for injection ampoules| 5 ampouleP£ 4. 71
Konakion MM 10 mg/ 1 ml solution for injection ampoules|
10 ampouleP£ 3. 78 DT = £ 3. 78
Capsule
▶Neokay(Neoceuticals Ltd)
Phytomenadione 1 mgNeoKay 1 mg capsules| 12 capsuleP
£ 3. 95 DT = £ 3. 95 | 100 capsuleP£ 34. 00
7.1 Neural tube defects
(prevention in pregnancy)
Neural tube defects (prevention in
pregnancy) 01-Aug-2017
Description of condition
Neural tube defects represent a group of congenital defects,
caused by incomplete closure of the neural tube within
28 days of conception. The most common forms are
anencephaly, spina bifida and encephalocele.
The main risk factors are maternal folate deficiency,
maternal vitamin B 12 deficiency, previous history of having
an infant with a neural tube defect, smoking, diabetes,
obesity, and use of antiepileptic drugs.
Prevention in pregnancy
gPregnant women or women who wish to become
pregnant should be advised to take supplementation with
folic acid p. 574 before conception and until week 12 of
pregnancy.
A higher daily dose (see folic acid) is recommended for
women at a high risk of conceiving a child with a neural tube
defect, including women who have previously had an infant
with a neural tube defect, who are receiving antiepileptic
medication (see Epilepsy p. 191 ), or who have diabetes or
sickle-cell disease.h
Useful Resources
Antenatal care for uncomplicated pregnancies. National
Institute for Health and Care Excellence. Clinical guideline
62. March 2008 (Updated March 2016 ).
http://www.nice.org.uk/guidance/cg 62
Fertility problems: assessment and treatment. National
Institute for Health and Care Excellence. Clinical guideline
156. June 2015.
http://www.nice.org.uk/guidance/cg 156
BNFC 2018 – 2019 Neural tube defects (prevention in pregnancy) 637
Blood and nutrition9