BNF for Children (BNFC) 2018-2019

lMEDICINAL FORMS

There can be variation in the licensing of different medicines

containing the same drug.

Ear/eye/nose drops solution

EXCIPIENTS:May contain Benzalkonium chloride, disodium edetate

▶Betnesol-N(RPH Pharmaceuticals AB)

Betamethasone (as Betamethasone sodium phosphate) 1 mg per

1 ml, Neomycin sulfate 5 mg per 1 mlBetnesol-N ear/eye/nose

drops| 10 mlP£ 2. 39 DT = £ 2. 39

Dexamethasone with framycetin

sulfate and gramicidin 21-Dec-2017

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, dexamethasone p. 668.

lINDICATIONS AND DOSE

Local treatment of inflammation (short-term)

▶TO THE EYE

▶Child:Apply 4 – 6 times a day, may be administered

every 30 – 60 minutes in severe conditions until

controlled, then reduce frequency

IMPORTANT SAFETY INFORMATION

MHRA/CHM ADVICE: CORTICOSTEROIDS: RARE RISK OF CENTRAL

SEROUS CHORIORETINOPATHY WITH LOCAL AS WELL AS SYSTEMIC

ADMINISTRATION (AUGUST 2017)

See Corticosteroids, general use p. 434.

lINTERACTIONS→Appendix 1 : corticosteroids

lLESS SUITABLE FOR PRESCRIBINGSofradex®is less

suitable for prescribing.

lMEDICINAL FORMS

There can be variation in the licensing of different medicines

containing the same drug.

Ear/eye drops solution

EXCIPIENTS:May contain Polysorbates

▶Sofradex(Sanofi)

Gramicidin 50 microgram per 1 ml, Dexamethasone (as

Dexamethasone sodium metasulfobenzoate) 500 microgram per

1 ml, Framycetin sulfate 5 mg per 1 mlSofradex ear/eye drops|

8 mlP£ 7. 50

Dexamethasone with hypromellose,

neomycin and polymyxin B sulfate

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, dexamethasone p. 668.

lINDICATIONS AND DOSE

Local treatment of inflammation (short-term)

▶TO THE EYE USING EYE DROP

▶Child:Apply every 30 – 60 minutes until controlled,

then reduced to 4 – 6 times a day

Local treatment of inflammation (short-term)

▶TO THE EYE USING EYE OINTMENT

▶Child:Apply 3 – 4 times a day, alternatively, apply at

night when used with eye drops

lINTERACTIONS→Appendix 1 : corticosteroids.neomycin

lLESS SUITABLE FOR PRESCRIBINGDexamethasone with

neomycin and polymixin B sulfate is less suitable for

prescribing.

lMEDICINAL FORMS

There can be variation in the licensing of different medicines

containing the same drug.

Eye ointment

EXCIPIENTS:May contain Hydroxybenzoates (parabens), woolfat and

related substances (including lanolin)

▶Maxitrol(Novartis Pharmaceuticals UK Ltd)

Dexamethasone 1 mg per 1 gram, Neomycin (as Neomycin

sulfate) 3500 unit per 1 gram, Polymyxin B sulfate 6000 unit per

1 gramMaxitrol eye ointment| 3. 5 gramP£ 1. 44

Eye drops

EXCIPIENTS:May contain Benzalkonium chloride, polysorbates

▶Maxitrol(Novartis Pharmaceuticals UK Ltd)

Dexamethasone 1 mg per 1 ml, Hypromellose 5 mg per 1 ml,

Neomycin (as Neomycin sulfate) 3500 unit per 1 ml, Polymyxin B

sulfate 6000 unit per 1 mlMaxitrol eye drops|^5 mlP£^1.^68

1.2a Anterior uveitis

ANTIMUSCARINICS

Antimuscarinics (eye) f

lCAUTIONSChildren under 3 months owing to the possible

association between cycloplegia and the development of

amblyopia.darkly pigmented iris is more resistant to

pupillary dilatation and caution should be exercised to

avoid overdosage.mydriasis can precipitate acute angle-

closure glaucoma (usually in those who are predisposed to

the condition because of a shallow anterior chamber).

neonates at increased risk of systemic toxicity

lSIDE-EFFECTSArrhythmias.conjunctivitis (on prolonged

administration).dry mouth.dry skin.eye oedema (on

prolonged administration.flushing.hyperaemia (on

prolonged administration).gastrointestinal disorders.

urinary disorders

lPATIENT AND CARER ADVICEPatients may not be able to

undertake skilled tasks until vision clears after mydriasis.

eiiiiFabove

Atropine sulfate

lINDICATIONS AND DOSE

Cycloplegia

▶TO THE EYE USING EYE DROP

▶Child 3 months–17 years:Apply twice daily for 3 days,

before procedure

Anterior uveitis

▶TO THE EYE USING EYE DROP

▶Child 2–17 years:Apply 1 drop up to 4 times a day

lUNLICENSED USENot licensed for use in children for

uveitis.

lINTERACTIONS→Appendix 1 : atropine

lSIDE-EFFECTS

SIDE-EFFECTS, FURTHER INFORMATIONSystemic side-

effects can occur.

lPRESCRIBING AND DISPENSING INFORMATIONAlthough

multi-dose atropine sulphate eye drops commonly contain

preservatives, preservative-free unit dose vials may be

available.

lMEDICINAL FORMS

There can be variation in the licensing of different medicines

containing the same drug. Forms available from special-order

manufacturers include: eye drops

Eye drops

▶Atropine sulfate (Non-proprietary)

Atropine sulfate 10 mg per 1 mlAtropine 1 % eye drops|

10 mlP£ 132. 25 DT = £ 132. 25

670 Allergic and inflammatory eye conditions BNFC 2018 – 2019

Eye

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