▶Atropine sulfate(Bausch & Lomb UK Ltd)
Atropine sulfate 10 mg per 1 mlMinims atropine sulfate 1 % eye
drops 0. 5 ml unit dose| 20 unit doseP£ 15. 10 DT = £ 15. 10eiiiiF 670Cyclopentolate hydrochloride
lINDICATIONS AND DOSE
Cycloplegia
▶TO THE EYE
▶Child 3 months–11 years:Apply 1 drop, 30 – 60 minutes
before examination, using 1 % eye drops
▶Child 12–17 years:Apply 1 drop, 30 – 60 minutes before
examination, using 0. 5 % eye drops
Uveitis
▶TO THE EYE
▶Child 3 months–17 years:Apply 1 drop 2 – 4 times a day,
using 0. 5 % eye drops ( 1 % for deeply pigmented eyes)lINTERACTIONS→Appendix 1 : cyclopentolate
lSIDE-EFFECTSMydriasis.photophobia
SIDE-EFFECTS, FURTHER INFORMATIONSystemic side-
effects can occur.lPRESCRIBING AND DISPENSING INFORMATIONAlthough
multi-dose cyclopentolate eye drops commonly contain
preservatives, preservative-free unit dose vials may be
available.
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Eye drops
EXCIPIENTS:May contain Benzalkonium chloride
▶Cyclopentolate hydrochloride(Bausch & Lomb UK Ltd)
Cyclopentolate hydrochloride 5 mg per 1 mlMinims cyclopentolate
hydrochloride 0. 5 % eye drops 0. 5 ml unit dose| 20 unit doseP
£ 11. 41 DT = £ 11. 41
Cyclopentolate hydrochloride 10 mg per 1 mlMinims
cyclopentolate hydrochloride 1 % eye drops 0. 5 ml unit dose| 20 unit
doseP£ 11. 68 DT = £ 11. 68
▶Mydrilate(Intrapharm Laboratories Ltd)
Cyclopentolate hydrochloride 5 mg per 1 mlMydrilate 0. 5 %
solution| 5 mlP£ 8. 08 DT = £ 8. 08
Cyclopentolate hydrochloride 10 mg per 1 mlMydrilate 1 %
solution| 5 mlP£ 8. 08 DT = £ 8. 08
eiiiiF 670Homatropine hydrobromide
lINDICATIONS AND DOSE
Anterior uveitis
▶TO THE EYE
▶Child 3 months–1 year:Apply 1 drop daily, alternatively
apply 1 drop once daily on alternate days, adjusted
according to response, only 0. 5 % eye drops to be used
▶Child 2–17 years:Apply 1 drop twice daily, adjusted
according to responselUNLICENSED USENot licensed for use in children under
3 months.
lINTERACTIONS→Appendix 1 : homatropine
lMEDICINAL FORMS
Forms available from special-order manufacturers include: eye
drops
2 Dry eye conditions
Dry eye
Tear deficiency, ocular lubricants, and astringents
Chronic soreness of the eyes associated with reduced or
abnormal tear secretion often responds to tear replacement
therapy. The severity of the condition and child’s preference
will often guide the choice of preparation.
Hypromellose p. 672 is the traditional choice of treatment
for tear deficiency. It may need to be instilled frequently (e.g.
hourly) for adequate relief. Ocular surface mucin is often
abnormal in tear deficiency and the combination of
hypromellose with a mucolytic such as acetylcysteine below
can be helpful.
The ability ofcarbomersto cling to the eye surface may
help reduce frequency of application to 4 times daily.
Polyvinyl alcohol p. 673 increases the persistence of the
tearfilm and is useful when the ocular surface mucin is
reduced.
Sodium hyaluronate eye drops p. 674 , with or without
trehalose, are also used in the management of tear
deficiency.
Sodium chloride 0. 9 % drops p. 673 are sometimes useful in
tear deficiency, and can be used as‘comfort drops’by
contact lens wearers, and to facilitate lens removal. Special
presentations of sodium chloride 0. 9 % and other irrigation
solutions are used routinely for intra-ocular surgery and in
first aid for removal of harmful substances.
Eye ointments containing a paraffin can be used to
lubricate the eye surface, especially in cases of recurrent
corneal epithelial erosion. They may cause temporary visual
disturbance and are best suited for application before sleep.
Ointments should not be used during contact lens wear.OCULAR LUBRICANTS
Acetylcysteine 07-Feb-2017
lINDICATIONS AND DOSE
Tear deficiency|Impaired or abnormal mucus production
▶TO THE EYE
▶Child:Apply 3 – 4 times a daylMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: eye drops
Eye drops
EXCIPIENTS:May contain Benzalkonium chloride, disodium edetate
▶Ilube(Rayner Pharmaceuticals Ltd)
Acetylcysteine 50 mg per 1 mlIlube 5 % eye drops| 10 mlP
£ 16. 90 DT = £ 16. 90Carbomers
(Polyacrylic acid)
lINDICATIONS AND DOSE
Dry eyes including keratoconjunctivitis sicca, unstable
tear film
▶TO THE EYE
▶Child:Apply 3 – 4 times a day or when requiredlUNLICENSED USESome preparations not licensed for use
in children.
lPRESCRIBING AND DISPENSING INFORMATIONSynthetic
high molecular weight polymers of acrylic acid cross-BNFC 2018 – 2019 Dry eye conditions 671
Eye11