▶Frequency not knownAnaphylactoid reaction.angioedema
.arthritis.ataxia.cough.encephalopathy.eye
inflammation.meningitis aseptic.nerve deafness.nerve
disorders.oculomotor nerve paralysis.oedema.
panniculitis.papillitis.paraesthesia.regional
lymphadenopathy.respiratory disorders.seizures.
Stevens-Johnson syndrome.subacute sclerosing
panencephalitis.syncope.throat pain.thrombocytopenia
.vasculitis
SIDE-EFFECTS, FURTHER INFORMATIONMalaise, fever, or a
rash can occur after thefirst dose of MMR vaccine–most
commonly about a week after vaccination and lasting
about 2 to 3 days. Febrile seizures occur rarely 6 to 11 days
after MMR vaccination (the incidence is lower than that
following measles infection).
Idiopathic thrombocytopenic purpuraIdiopathic
thrombocytopenic purpura has occurred rarely following
MMR vaccination, usually within 6 weeks of thefirst dose.
The risk of idiopathic thrombocytopenic purpura after
MMR vaccine is much less than the risk after infection with
wild measles or rubella virus. Children who develop
idiopathic thrombocytopenic purpura within 6 weeks of
thefirst dose of MMR should undergo serological testing
before the second dose is due; if the results suggest
incomplete immunity against measles, mumps or rubella
then a second dose of MMR is recommended. Samples
should be sent to the Virus Reference Laboratory of the
Health Protection Agency.
Frequency of side effectsAdverse reactions are
considerably less frequent after the second dose of MMR
vaccine than after thefirst.
lALLERGY AND CROSS-SENSITIVITYMMR vaccine can be
given safely even when the child has had an anaphylactic
reaction to food containing egg. Dislike of eggs, refusal to
eat egg, or confirmed anaphylactic reactions to egg-
containing food is not a contra-indication to MMR
vaccination. Children with a confirmed anaphylactic
reaction to the MMR vaccine should be assessed by a
specialist.
lCONCEPTION AND CONTRACEPTIONExclude pregnancy
before immunisation. Avoid pregnancy for at least
1 month after vaccination.
lPRESCRIBING AND DISPENSING INFORMATIONAvailable as
part of childhood immunisation schedule from health
organisations or ImmFormwww.immform.dh.gov.uk.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Powder and solvent for suspension for injection
EXCIPIENTS:May contain Gelatin, neomycin
▶M-M-RVAXPRO(Merck Sharp & Dohme Ltd)
M-M-RVAXPRO vaccine powder and solvent for suspension for injection
0. 5 ml pre-filled syringes| 1 pre-filled disposable injectionP
£ 11. 00
Powder and solvent for solution for injection
EXCIPIENTS:May contain Neomycin
▶Priorix(GlaxoSmithKline UK Ltd)
Priorix vaccine powder and solvent for solution for injection 0. 5 ml pre-
filled syringes| 1 pre-filled disposable injectionP£ 7. 64eiiiiF 788Rabies vaccine
lINDICATIONS AND DOSE
Pre-exposure prophylaxis
▶BY INTRAMUSCULAR INJECTION
▶Child: 1 mL for 2 doses (on days 0 and 7 ), followed by
1 mL for 1 dose (on day 28 ), to be administered in
deltoid region or anterolateral thigh in infants, for
those at continuous risk, measure plasma-
concentration of antirabies antibodies every 6 monthsand give a booster dose if the titre is less than
0. 5 units/mL,final dose may be given from day 21 ,if
insufficient time before travel
Pre-exposure prophylaxis booster dose (for patients at
frequent risk of exposure)
▶BY INTRAMUSCULAR INJECTION
▶Child: 1 mL after 1 year for 1 dose, to be given 1 year
after primary course is completed, then 1 mL every
3 – 5 years, to be administered in deltoid region or
anterolateral thigh in infants, the frequency of booster
doses may alternatively be determined according to
plasma-concentration of antirabies antibodies
Pre-exposure prophylaxis booster dose (for patients at
infrequent risk of exposure)
▶BY INTRAMUSCULAR INJECTION
▶Child: 1 mL for 1 dose, to be given 10 years after
primary course is completed, administered in deltoid
region or anterolateral thigh in infants
Post-exposure prophylaxis of fully immunised individuals
(who have previously received pre-exposure or post-
exposure prophylaxis with cell-derived rabies vaccine)
▶BY INTRAMUSCULAR INJECTION
▶Child (administered on expert advice): 1 mL for 1 dose,
followed by 1 mL after 3 – 7 days for 1 dose, to be
administered in deltoid region or anterolateral thigh in
infants, rabies immunoglobulin is not necessary
Post-exposure treatment for unimmunised individuals (or
those whose prophylaxis is possibly incomplete)
▶BY INTRAMUSCULAR INJECTION
▶Child (administered on expert advice): 1 mL 5 times a
month for 1 month, doses should be given on days 0 , 3 ,
7 , 14 , and thefifth dose is given between day 28 – 30 ,to
be administered in deltoid region or anterolateral thigh
in infants, depending on the level of risk (determined
by factors such as the nature of the bite and the
country where it was sustained), rabies
immunoglobulin is given to unimmunised individuals
on day^0 or within^7 days of starting the course of
rabies vaccine, the immunisation course can be
discontinued if it is proved that the individual was not
at risklINTERACTIONS→Appendix 1 : rabies vaccine
lSIDE-EFFECTS
▶Common or very commonAsthenia.gastrointestinal
discomfort
▶Rare or very rareAnaphylactic shock.angioedema.chills.
encephalitis.Guillain-Barre syndrome.hyperhidrosis.
paraesthesia.presyncope.syncope.vertigo
lPREGNANCYBecause of the potential consequences of
untreated rabies exposure and because rabies vaccination
has not been associated with fetal abnormalities,
pregnancy is not considered a contra-indication to post-
exposure prophylaxis. Immunisation against rabies is
indicated during pregnancy if there is substantial risk of
exposure to rabies and rapid access to post-exposure
prophylaxis is likely to be limited.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Powder and solvent for solution for injection
EXCIPIENTS:May contain Neomycin
▶Rabipur(GlaxoSmithKline UK Ltd)
Rabipur vaccine powder and solvent for solution for injection 1 ml vials
| 1 vialP£ 34. 56
Rabipur vaccine powder and solvent for solution for injection 1 ml pre-
filled syringes| 1 pre-filled disposable injectionP£ 34. 56800 Vaccination BNFC 2018 – 2019
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