eiiiiF 489Propantheline bromide
lINDICATIONS AND DOSE
Symptomatic relief of gastro-intestinal disorders
characterised by smooth muscle spasm
▶BY MOUTH
▶Child 1 month–11 years: 300 micrograms/kg 3 – 4 times a
day (max. per dose 15 mg), dose to be taken at least one
hour before food
▶Child 12–17 years: 15 mg 3 times a day, dose to be taken
at least one hour before food and 30 mg, dose to be
taken at night; maximum 120 mg per daylUNLICENSED USETabletsnot licensed for use in children
under 12 years.
lINTERACTIONS→Appendix 1 : propantheline
lSIDE-EFFECTSArrhythmias.bronchial secretion decreased
.mydriasis.photophobia.urinary hesitation
lPREGNANCYManufacturer advises avoid unless
essential—no information available.
lBREAST FEEDINGMay suppress lactation.
lHEPATIC IMPAIRMENTManufacturer advises caution.
lRENAL IMPAIRMENTManufacturer advises caution.
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension, oral solution
Tablet
CAUTIONARY AND ADVISORY LABELS 23
▶Pro-Banthine(Kyowa Kirin Ltd)
Propantheline bromide 15 mgPro-Banthine 15 mg tablets|
112 tabletP£ 20. 74 DT = £ 20. 74
ANTISPASMODICS
Alverine citrate 24-Feb-2016
lINDICATIONS AND DOSE
Symptomatic relief of gastro-intestinal disorders
characterised by smooth muscle spasm|Dysmenorrhoea
▶BY MOUTH
▶Child 12–17 years: 60 – 120 mg 1 – 3 times a daylCONTRA-INDICATIONSIntestinal obstruction.paralytic
ileus
lSIDE-EFFECTSDizziness.dyspnoea.headache.jaundice
(reversible on discontinuation).nausea.skin reactions.
wheezing
lPREGNANCYManufacturer advises avoid—limited
information available
lBREAST FEEDINGManufacturer advises avoid—limited
information available.
lPATIENT AND CARER ADVICE
Driving and skilled tasksDizziness may affect performance
of skilled tasks (e.g. driving).
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Capsule
▶Alverine citrate (Non-proprietary)
Alverine citrate 60 mgAlverine 60 mg capsules| 100 capsulep
£ 19. 49 DT = £ 4. 78
Alverine citrate 120 mgAlverine 120 mg capsules| 60 capsulep
£ 23. 28 DT = £ 23. 28
▶Audmonal(Teva UK Ltd)
Alverine citrate 60 mgAudmonal 60 mg capsules| 100 capsulep
£ 14. 80 DT = £ 4. 78
Alverine citrate 120 mgAudmonal Forte 120 mg capsules|
60 capsulep£ 17. 75 DT = £ 23. 28
▶Gielism(HFA Healthcare Products Ltd)
Alverine citrate 60 mgGielism 60 mg capsules| 100 capsulep
£ 19. 48 DT = £ 4. 78
▶Spasmonal(Meda Pharmaceuticals Ltd)
Alverine citrate 60 mgSpasmonal 60 mg capsules| 100 capsulep
£ 16. 45 DT = £ 4. 78
Alverine citrate 120 mgSpasmonal Forte 120 mg capsules|
60 capsulep£ 19. 42 DT = £ 23. 28Mebeverine hydrochloride
lINDICATIONS AND DOSE
Adjunct in gastro-intestinal disorders characterised by
smooth muscle spasm
▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES
▶Child 3 years: 25 mg 3 times a day, dose preferably
taken 20 minutes before meals
▶Child 4–7 years: 50 mg 3 times a day, dose preferably
taken 20 minutes before meals
▶Child 8–9 years: 100 mg 3 times a day, dose preferably
taken 20 minutes before meals
▶Child 10–17 years: 135 – 150 mg 3 times a day, dose
preferably taken 20 minutes before meals
Irritable bowel syndrome
▶BY MOUTH USING MODIFIED-RELEASE MEDICINES
▶Child 12–17 years: 200 mg twice dailylUNLICENSED USETablets and liquidnot licensed for use in
children under 10 years.Granulesnot licensed for use in
children under 12 years.Modified-release capsulesnot
licensed for use in children under 18 years.
lCONTRA-INDICATIONSParalytic ileus
lSIDE-EFFECTSAngioedema.face oedema.skin reactions
lPREGNANCYNot known to be harmful—manufacturers
advise avoid.
lBREAST FEEDINGManufacturers advise avoid—no
information available.
lPATIENT AND CARER ADVICEPatients or carers should be
given advice on the timing of administration of
mebeverine hydrochloride tablets and oral suspension.
Medicines for Children leaflet: Mebeverine for intestinal spasm
http://www.medicinesforchildren.org.uk/mebeverine-for-intestinal-
spasmslMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Oral suspension
▶Mebeverine hydrochloride (Non-proprietary)
Mebeverine hydrochloride (as Mebeverine pamoate) 10 mg per
1mlMebeverine 50 mg/ 5 ml oral suspension sugar free sugar-free|
300 mlP£ 187. 00 DT = £ 187. 00
Modified-release capsule
CAUTIONARY AND ADVISORY LABELS 25
▶Mebeverine hydrochloride (Non-proprietary)
Mebeverine hydrochloride 200 mgMebeverine 200 mg modified-
release capsules| 60 capsuleP£ 6. 92 DT = £ 6. 92
▶Aurobeverine MR(Milpharm Ltd)
Mebeverine hydrochloride 200 mgAurobeverine MR 200 mg
capsules| 60 capsuleP£ 6. 92 DT = £ 6. 92
▶Colofac MR(Mylan)
Mebeverine hydrochloride 200 mgColofac MR 200 mg capsules|
60 capsuleP£ 6. 92 DT = £ 6. 92
Tablet
▶Mebeverine hydrochloride (Non-proprietary)
Mebeverine hydrochloride 135 mgMebeverine 135 mg tablets|
100 tabletP£ 20. 00 DT = £ 4. 35
▶Colofac(Mylan)
Mebeverine hydrochloride 135 mgColofac 135 mg tablets|
100 tabletP£ 9. 02 DT = £ 4. 35
Colofac IBS 135 mg tablets| 15 tabletp£ 2. 83BNFC 2018 – 2019 Gastro-intestinal smooth muscle spasm 63
Gastro-intestinal system1