▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to moderately increase the exposure toalpha
blockers(alfuzosin, tamsulosin). Use with caution or avoid.
oStudy
▶Aprepitantis predicted to increase the exposure totamsulosin.
oTheoretical
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure totamsulosin.oTheoretical→Also
seeTABLE 8p. 848
▶Cobicistatis predicted to moderately increase the exposure to
alpha blockers(alfuzosin, tamsulosin). Use with caution or
avoid.oStudy
▶Cobicistatis predicted to increase the exposure todoxazosin.
oStudy
▶Crizotinibis predicted to increase the exposure totamsulosin.
oTheoretical
▶HIV-protease inhibitorsare predicted to moderately increase
the exposure toalpha blockers(alfuzosin, tamsulosin). Use with
caution or avoid.oStudy
▶HIV-protease inhibitorsare predicted to increase the exposure
todoxazosin.oStudy
▶Idelalisibis predicted to moderately increase the exposure to
alpha blockers(alfuzosin, tamsulosin). Use with caution or
avoid.oStudy
▶Idelalisibis predicted to increase the exposure todoxazosin.
oStudy
▶Imatinibis predicted to increase the exposure totamsulosin.
oTheoretical
▶Macrolides(clarithromycin)are predicted to increase the
exposure todoxazosin.oStudy
▶Macrolides(erythromycin)are predicted to increase the
exposure totamsulosin.oTheoretical
▶Macrolides(clarithromycin)are predicted to moderately
increase the exposure toalpha blockers(alfuzosin, tamsulosin).
Use with caution or avoid.oStudy
▶Monoamine-oxidase A and B inhibitors, irreversibleare
predicted to increase the effects ofindoramin. Avoid.r
Theoretical→Also seeTABLE 8p. 848
▶Netupitantis predicted to increase the exposure totamsulosin.
oTheoretical
▶Nilotinibis predicted to increase the exposure totamsulosin.
oTheoretical
▶Alpha blockerscause significant hypotensive effects when
given withphosphodiesterase type-5 inhibitors. Patient should
be stabilised onfirst drug then second drug should be added
at the lowest recommended dose.rStudy→Also see
TABLE 8p. 848
▶Ribociclib(high-dose) is predicted to increase the exposure to
alfuzosin. Avoid.oTheoretical
Alpha tocopherol→see vitamin E substances
Alpha tocopheryl acetate→see vitamin E substances
Alprazolam→seeTABLE 11p. 849 (CNS depressant effects)
▶Antiarrhythmics(dronedarone)are predicted to increase the
exposure toalprazolam.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toalprazolam. Adjust dose.oTheoretical→Also see
TABLE 11p. 849
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure toalprazolam.r
Study
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)
moderately increase the exposure toalprazolam. Avoid.
oStudy
▶Antifungals, azoles(miconazole)are predicted to increase the
exposure toalprazolam. Use with caution and adjust dose.
oTheoretical
▶Aprepitantis predicted to increase the exposure toalprazolam.
rStudy
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure toalprazolam.rStudy
▶Cobicistatmoderately increases the exposure toalprazolam.
Avoid.oStudy
▶Crizotinibis predicted to increase the exposure toalprazolam.
rStudy
▶Enzalutamideis predicted to decrease the exposure to
alprazolam. Adjust dose.oTheoretical
▶HIV-protease inhibitorsmoderately increase the exposure to
alprazolam. Avoid.oStudy
▶Idelalisibmoderately increases the exposure toalprazolam.
Avoid.oStudy
▶Imatinibis predicted to increase the exposure toalprazolam.
rStudy
▶Alprazolamis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Macrolides(clarithromycin)moderately increase the exposure
toalprazolam. Avoid.oStudy
▶Macrolides(erythromycin)are predicted to increase the
exposure toalprazolam.rStudy
▶Mitotaneis predicted to decrease the exposure toalprazolam.
Adjust dose.oTheoretical
▶Monoclonal antibodies(tocilizumab)are predicted to decrease
the exposure toalprazolam. Monitor and adjust dose.
oTheoretical
▶Netupitantis predicted to increase the exposure toalprazolam.
rStudy
▶Nilotinibis predicted to increase the exposure toalprazolam.
rStudy
▶Rifampicinis predicted to decrease the exposure to
alprazolam. Adjust dose.oTheoretical
▶SSRIs(fluvoxamine)moderately increase the exposure to
alprazolam. Adjust dose.oStudy
▶St John’sWortmoderately decreases the exposure to
alprazolam.oStudy
Alprostadil→seeTABLE 8p. 848 (hypotension)
Alteplase→seeTABLE 3p. 847 (anticoagulant effects)
Aluminium hydroxide→see antacids
Amantadine→see dopamine receptor agonists
Ambrisentan
▶Ciclosporinmoderately increases the exposure toambrisentan.
Adjustambrisentandose.oStudy
▶Rifampicintransiently increases the exposure toambrisentan.
oStudy
Amfetamines→seeTABLE 13p. 850 (serotonin syndrome)
dexamfetamine.lisdexamfetamine..▶Amfetaminesare predicted to decrease the effects of
apraclonidine. Avoid.rTheoretical
▶Amfetaminesare predicted to increase the risk of side-effects
when given withatomoxetine.rTheoretical
▶Dexamfetaminedecreases the effects ofguanethidine.r
Study
▶HIV-protease inhibitors(ritonavir, tipranavir)are predicted to
increase the exposure toamfetamines.rTheoretical
▶Moclobemideis predicted to increase the risk of a hypertensive
crisis when given withamfetamines. Avoid.r
Theoretical→Also seeTABLE 13p. 850
▶Monoamine-oxidase A and B inhibitors, irreversibleare
predicted to increase the risk of a hypertensive crisis when
given withamfetamines. Avoid and for 14 days after stopping
the MAOI.rAnecdotal→Also seeTABLE 13p. 850
▶Monoamine-oxidase B inhibitors(rasagiline, selegiline)are
predicted to increase the risk of severe hypertension when
given withamfetamines. Avoid.rTheoretical→Also see
TABLE 13p. 850
▶Monoamine-oxidase B inhibitors(safinamide)are predicted to
increase the risk of severe hypertension when given with
amfetamines.rTheoretical→Also seeTABLE 13p. 850
▶Nabiloneis predicted to increase the risk of cardiovascular
side-effects when given withamfetamines.rTheoretical
▶Phenothiazinesare predicted to decrease the effects of
amfetamines.oStudy
▶Amfetaminesare predicted to decrease the effects of
phenothiazines(chlorpromazine).oStudy
▶SSRIs(fluoxetine, paroxetine)are predicted to increase the
exposure toamfetamines.rTheoretical→Also seeTABLE 13
p. 850
Amifampridine→seeTABLE 9p. 849 (QT-interval prolongation)
Amikacin→see aminoglycosides
Amiloride→see potassium-sparing diureticsBNFC 2018 – 2019 Alpha blockers—Amiloride 855
Interactions|Appendix 1A1