Blinatumomab→see monoclonal antibodies
Bortezomib→seeTABLE 8p. 848 (hypotension),TABLE 15p. 850
(myelosuppression),TABLE 12p. 850 (peripheral neuropathy)
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)slightly decrease the exposure to
bortezomib. Avoid.rStudy→Also seeTABLE 12p. 850
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)
slightly increase the exposure tobortezomib.oStudy
▶Cobicistatslightly increases the exposure tobortezomib.
oStudy
▶Enzalutamideslightly decreases the exposure tobortezomib.
Avoid.rStudy
▶HIV-protease inhibitorsslightly increase the exposure to
bortezomib.oStudy
▶Idelalisibslightly increases the exposure tobortezomib.
oStudy→Also seeTABLE 15p. 850
▶Macrolides(clarithromycin)slightly increase the exposure to
bortezomib.oStudy
▶Mitotaneslightly decreases the exposure tobortezomib. Avoid.
rStudy→Also seeTABLE 15p. 850
▶Rifampicinslightly decreases the exposure tobortezomib.
Avoid.rStudy
Bosentan
▶Bosentanis predicted to decrease the exposure to
antiarrhythmics(dronedarone).rTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)affect the exposure tobosentan. Avoid.
rStudy
▶Antifungals, azoles(fluconazole)are predicted to increase the
exposure tobosentan. Avoid.rStudy
▶Antifungals, azoles(itraconazole)are predicted to increase the
exposure tobosentan.oTheoretical
▶Antifungals, azoles(ketoconazole)moderately increase the
exposure tobosentan.oStudy
▶Antifungals, azoles(voriconazole)are predicted to increase the
exposure tobosentan. Avoid.rTheoretical
▶Bosentanis predicted to decrease the exposure toantifungals,
azoles(isavuconazole). Avoid.rTheoretical
▶Bosentanis predicted to decrease the exposure toaxitinib.
oTheoretical
▶Bosentanis predicted to decrease the exposure tobedaquiline.
Avoid.rStudy
▶Bosentanis predicted to decrease the exposure tobosutinib.
Avoid.rTheoretical
▶Bosentanis predicted to decrease the exposure to
cabozantinib.oTheoretical
▶Bosentanis predicted to decrease the exposure tocalcium
channel blockers(amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nifedipine, nimodipine). Monitor and
adjust dose.oTheoretical
▶Bosentanis predicted to decrease the exposure tocalcium
channel blockers(diltiazem, verapamil).oTheoretical
▶Cephalosporins(ceftobiprole)are predicted to increase the
exposure tobosentan.oTheoretical
▶Bosentanmoderately decreases the exposure tociclosporin
andciclosporinmoderately increases the exposure to
bosentan. Avoid.rStudy
▶Bosentanis predicted to decrease the exposure tocobicistat.
Avoid.rTheoretical
▶Bosentanis predicted to decrease the exposure tocobimetinib.
Avoid.rTheoretical
▶Bosentanis predicted to decrease the efficacy ofcombined
hormonal contraceptives. For FSRH guidance, see
Contraceptives, interactionsp. 497.rStudy
▶Bosentandecreases the anticoagulant effect ofcoumarins.
oStudy
▶Bosentanis predicted to decrease the exposure tocrizotinib.
Avoid.rTheoretical
▶Bosentanis predicted to decrease the exposure todaclatasvir.
Adjustdaclatasvirdose.oTheoretical
▶Bosentanis predicted to decrease the exposure todasatinib.
rStudy
▶Bosentanis predicted to decrease the efficacy ofdesogestrel.
For FSRH guidance, seeContraceptives, interactionsp. 497.
rTheoretical▶Bosentandecreases the exposure todolutegravir. Adjust dose.
rStudy
▶Bosentanis predicted to moderately decrease the exposure to
elbasvir. Avoid.rStudy
▶Bosentanis predicted to decrease the exposure toeliglustat.
oTheoretical
▶Bosentanis predicted to decrease the concentration of
elvitegravir. Avoid.rTheoretical
▶Enzalutamideaffects the exposure tobosentan. Avoid.r
Study
▶Bosentanis predicted to decrease the effects ofergotamine.
oTheoretical
▶Bosentanis predicted to decrease the exposure toerlotinib.
rTheoretical
▶Bosentanis predicted to decrease the efficacy ofetonogestrel.
For FSRH guidance, seeContraceptives, interactionsp. 497.
rTheoretical
▶Bosentanis predicted to decrease the exposure toetravirine.
Avoid.rStudy
▶Bosentanis predicted to decrease the concentration of
everolimus. Avoid or adjust dose.rStudy
▶Bosentanis predicted to decrease the exposure togefitinib.
Avoid.rTheoretical
▶Bosentanis predicted to decrease the exposure toglecaprevir.
Avoid.rStudy
▶Bosentanis predicted to markedly decrease the exposure to
grazoprevir. Avoid.rStudy
▶Bosentanis predicted to decrease the concentration of
guanfacine. Adjust dose.oTheoretical
▶HIV-protease inhibitorsare predicted to increase the exposure
tobosentan.rStudy
▶Bosentanis predicted to decrease the effects ofhormone
replacement therapy.oAnecdotal
▶Bosentanis predicted to decrease the exposure toidelalisib.
Avoid.oTheoretical
▶Bosentanis predicted to decrease the exposure toimatinib.
oStudy
▶Bosentanis predicted to decrease the exposure toivacaftor.
rTheoretical
▶Bosentanis predicted to decrease the exposure tolapatinib.
Avoid.rStudy
▶Bosentanis predicted to decrease the efficacy of
levonorgestrel. For FSRH guidance, seeContraceptives,
interactionsp. 497.rTheoretical
▶Bosentanis predicted to decrease the exposure tolurasidone.
Monitor and adjust dose.oTheoretical
▶Macrolides(clarithromycin)are predicted to increase the
exposure tobosentan.oTheoretical
▶Bosentanis predicted to decrease the exposure tomaraviroc.
Avoid.oTheoretical
▶Bosentanis predicted to decrease the concentration of
midazolam. Monitor and adjust dose.oTheoretical
▶Mitotaneaffects the exposure tobosentan. Avoid.rStudy
▶Bosentanis predicted to decrease the exposure tonetupitant.
oTheoretical
▶Bosentanis predicted to decrease the exposure tonilotinib.
Avoid.rTheoretical
▶Bosentanis predicted to decrease the efficacy of
norethisterone. For FSRH guidance, seeContraceptives,
interactionsp. 497.rAnecdotal
▶Bosentanis predicted to decrease the exposure toolaparib.
Avoid.oTheoretical
▶Bosentandecreases the exposure toopioids(methadone).
Monitor and adjust dose.rStudy
▶Bosentanis predicted to decrease the exposure toosimertinib.
oTheoretical
▶Bosentanis predicted to decrease the exposure toparitaprevir
(with ritonavir and ombitasvir). Avoid.rStudy
▶Bosentandecreases the exposure tophosphodiesterase type-5
inhibitors.oStudy
▶Bosentanis predicted to decrease the exposure topibrentasvir.
Avoid.rStudy
▶Bosentanis predicted to decrease the exposure toquetiapine.
oStudy886 Blinatumomab—Bosentan BNFC 2018 – 2019
Interactions|Appendix 1A1