Cephalosporins(continued)
▶Ceftriaxoneincreases the risk of cardio-respiratory arrest
when given withcalcium salts(calcium chloride). Avoid.r
Anecdotal
▶Ceftriaxoneincreases the risk of cardio-respiratory arrest
when given with intravenouscalcium salts(calcium gluconate).
Avoid.rAnecdotal
▶Ceftriaxonepotentially increases the risk of bleeding events
when given withcoumarins.rAnecdotal
▶Ceftriaxonepotentially increases the risk of bleeding events
when given withphenindione.rAnecdotal
▶Ceftobiproleis predicted to increase the concentration of
statins.oTheoretical
▶Ceftobiproleis predicted to increase the concentration of
sulfonylureas(glibenclamide).oTheoretical
Ceritinib→seeTABLE 15p. 850 (myelosuppression),TABLE 9p. 849 (QT-
interval prolongation)
▶Ceritinibis predicted to increase the exposure toaliskiren.
oTheoretical
▶Antacidsare predicted to decrease the absorption ofceritinib.
Separate administration by 2 hours.oTheoretical
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
increase the exposure toceritinib.oTheoretical→Also
seeTABLE 9p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toceritinib. Avoid.rStudy
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure toceritinib.o
Theoretical→Also seeTABLE 9p. 849
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure toceritinib. Avoid or adjust
ceritinibdose.rStudy→Also seeTABLE 9p. 849
▶Ceritinibis predicted to increase the exposure to
antihistamines, non-sedating(fexofenadine).oTheoretical
▶Aprepitantis predicted to increase the exposure toceritinib.
oTheoretical
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure toceritinib.oTheoretical
▶Ceritinibis predicted to increase the exposure tociclosporin.
Avoid.rTheoretical
▶Cobicistatis predicted to increase the exposure toceritinib.
Avoid or adjustceritinibdose.rStudy
▶Ceritinibis predicted to increase the exposure tocolchicine.
oTheoretical
▶Ceritinibis predicted to increase the exposure tocoumarins
(warfarin). Avoid.rTheoretical
▶Crizotinibis predicted to increase the exposure toceritinib.
oTheoretical→Also seeTABLE 15p. 850→Also seeTABLE 9
p. 849
▶Ceritinibis predicted to increase the exposure todabigatran.
oTheoretical
▶Ceritinibis predicted to increase the risk of bradycardia when
given withdigoxin. Avoid.rTheoretical
▶Ceritinibis predicted to increase the exposure toedoxaban.
oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
ceritinib. Avoid.rStudy
▶Ceritinibis predicted to increase the exposure toergotamine.
Avoid.rTheoretical
▶Ceritinibis predicted to increase the exposure toeverolimus.
oTheoretical→Also seeTABLE 15p. 850
▶Grapefruit juiceis predicted to increase the exposure to
ceritinib. Avoid.rTheoretical
▶H 2 receptor antagonistsare predicted to decrease the
absorption ofceritinib.oTheoretical
▶HIV-protease inhibitorsare predicted to increase the exposure
toceritinib. Avoid or adjustceritinibdose.rStudy→Also
seeTABLE 9p. 849
▶Idelalisibis predicted to increase the exposure toceritinib.
Avoid or adjustceritinibdose.rStudy→Also seeTABLE 15
p. 850
▶Imatinibis predicted to increase the exposure toceritinib.
oTheoretical→Also seeTABLE 15p. 850▶Lapatinibis predicted to increase the exposure toceritinib.
oTheoretical→Also seeTABLE 9p. 849
▶Ceritinibis predicted to increase the exposure toloperamide.
oTheoretical
▶Macrolides(azithromycin, erythromycin)are predicted to
increase the exposure toceritinib.oTheoretical→Also
seeTABLE 9p. 849
▶Macrolides(clarithromycin)are predicted to increase the
exposure toceritinib. Avoid or adjustceritinibdose.r
Study→Also seeTABLE 9p. 849
▶Mitotaneis predicted to decrease the exposure toceritinib.
Avoid.rStudy→Also seeTABLE 15p. 850
▶Netupitantis predicted to increase the exposure toceritinib.
oTheoretical
▶Nilotinibis predicted to increase the exposure toceritinib.
oTheoretical→Also seeTABLE 15p. 850→Also seeTABLE 9
p. 849
▶Ceritinibis predicted to increase the exposure toNSAIDs
(celecoxib, diclofenac). Adjust dose.oTheoretical
▶Ceritinibis predicted to increase the exposure toopioids
(alfentanil, fentanyl). Avoid.rTheoretical
▶Ceritinibis predicted to increase the exposure topimozide.
Avoid.rTheoretical→Also seeTABLE 9p. 849
▶Proton pump inhibitorsare predicted to decrease the
absorption ofceritinib.oTheoretical
▶Ranolazineis predicted to increase the exposure toceritinib.
oTheoretical→Also seeTABLE 9p. 849
▶Rifampicinis predicted to decrease the exposure toceritinib.
Avoid.rStudy
▶Ceritinibis predicted to increase the exposure tosirolimus.
Avoid.rTheoretical
▶St John’s Wortis predicted to decrease the exposure to
ceritinib. Avoid.rTheoretical
▶Ceritinibis predicted to increase the exposure tosulfonylureas
(glimepiride). Adjust dose.oTheoretical
▶Ceritinibis predicted to increase the exposure totacrolimus.
Avoid.rTheoretical
▶Ceritinibis predicted to increase the exposure totaxanes
(paclitaxel).oTheoretical→Also seeTABLE 15p. 850
▶Ceritinibis predicted to increase the exposure totopotecan.
oTheoretical→Also seeTABLE 15p. 850
Certolizumab pegol→see monoclonal antibodies
Cetirizine→see antihistamines, non-sedating
Cetuximab→see monoclonal antibodies
Chenodeoxycholic acid
▶Oralantacids(aluminium hydroxide)decrease the absorption of
chenodeoxycholic acid.oStudy
▶Antiepileptics(phenobarbital, primidone)are predicted to affect
the efficacy ofchenodeoxycholic acid. Monitor and adjust dose.
oTheoretical
▶Ciclosporinis predicted to affect the efficacy of
chenodeoxycholic acid. Monitor and adjust dose.o
Theoretical
▶Oralcombined hormonal contraceptivespotentially decrease
the efficacy ofchenodeoxycholic acid. Avoid.o
Theoretical
▶Sirolimusis predicted to affect the efficacy ofchenodeoxycholic
acid. Monitor and adjust dose.oTheoretical
Chloral hydrate→seeTABLE 11p. 849 (CNS depressant effects)
▶Intravenousloop diuretics(furosemide)potentially increase the
risk of sweating, variable blood pressure, and tachycardia
when given afterchloral hydrate.oAnecdotal
Chlorambucil→see alkylating agents
Chloramphenicol
ROUTE-SPECIFIC INFORMATIONSince systemic absorption can
follow topical application, the possibility of interactions
should be borne in mind.
▶Antiepileptics(phenobarbital, primidone)decrease the
concentration ofchloramphenicol.oStudy
▶Intravenouschloramphenicolincreases the concentration of
antiepileptics(fosphenytoin, phenytoin)andantiepileptics
(fosphenytoin, phenytoin)affect the concentration of
intravenouschloramphenicol. Monitor concentration and
adjust dose.rStudy894 Cephalosporins—Chloramphenicol BNFC 2018 – 2019
Interactions|Appendix 1A1