▶Enzalutamideis predicted to decrease the exposure to
buspirone. Use with caution and adjust dose.rStudy
▶Enzalutamidemoderately decreases the exposure to
cabozantinib. Avoid.oStudy
▶Enzalutamideis predicted to decrease the exposure tocalcium
channel blockers(amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nifedipine, nimodipine). Monitor and
adjust dose.oStudy
▶Enzalutamideis predicted to decrease the exposure tocalcium
channel blockers(diltiazem, verapamil).rStudy
▶Enzalutamideis predicted to decrease the exposure to
cannabis extract. Avoid.rTheoretical
▶Enzalutamideis predicted to decrease the exposure to
ceritinib. Avoid.rStudy
▶Enzalutamidedecreases the concentration ofciclosporin.
rStudy
▶Enzalutamideis predicted to alter the effects ofcilostazol.
oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
cinacalcet. Monitor and adjust dose.oStudy
▶Enzalutamidedecreases the exposure toclomethiazole.
Monitor and adjust dose.oStudy
▶Clopidogrelmoderately increases the exposure to
enzalutamide. Avoid or adjustenzalutamidedose.rStudy
▶Enzalutamideis predicted to decrease the exposure to
clozapine.oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
cobicistat. Avoid.rTheoretical
▶Enzalutamideis predicted to decrease the exposure to
cobimetinib. Avoid.rTheoretical
▶Enzalutamideis predicted to decrease the exposure to
corticosteroids(budesonide, deflazacort, dexamethasone,
fludrocortisone, hydrocortisone, methylprednisolone,
prednisolone, prednisone, triamcinolone). Monitor and adjust
dose.oStudy
▶Enzalutamideis predicted to decrease the exposure to
corticosteroids(fluticasone).qTheoretical
▶Enzalutamidepotentially decreases the exposure tocoumarins.
Avoid or adjust dose and monitor INR.rStudy
▶Enzalutamideis predicted to markedly decrease the exposure
tocrizotinib. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
dabrafenib. Avoid.oTheoretical
▶Enzalutamideis predicted to moderately decrease the
exposure todaclatasvir. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
darifenacin.oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
dasabuvir. Avoid.rTheoretical
▶Enzalutamideis predicted to markedly decrease the exposure
todasatinib. Avoid.rStudy
▶Enzalutamideis predicted to slightly decrease the exposure to
delamanid. Avoid.oStudy
▶Enzalutamidedecreases the exposure todolutegravir. Adjust
dose.rStudy
▶Enzalutamideis predicted to decrease the exposure toelbasvir.
Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
eliglustat. Avoid.rStudy
▶Enzalutamideis predicted to decrease the concentration of
elvitegravir. Avoid.rTheoretical
▶Enzalutamideis predicted to decrease the effects of
ergotamine.oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
erlotinib. Avoid or adjusterlotinibdose.rStudy
▶Enzalutamideis predicted to decrease the exposure to
etravirine. Avoid.rTheoretical
▶Enzalutamideis predicted to decrease the concentration of
everolimus. Avoid or adjust dose.rStudy
▶Enzalutamidemoderately decreases the exposure to
exemestane.oStudy
▶Enzalutamideis predicted to decrease the exposure to
fesoterodine. Avoid.oStudy
▶Fibrates(gemfibrozil)moderately increase the exposure to
enzalutamide. Avoid or adjustenzalutamidedose.rStudy
▶Enzalutamideis predicted to decrease the exposure to
fingolimod.oStudy
▶Enzalutamideis predicted to decrease the exposure to
fosaprepitant. Avoid.oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
gefitinib. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
grazoprevir. Avoid.rStudy
▶Enzalutamideis predicted to decrease the concentration of
guanfacine. Adjustguanfacinedose,p. 231.oStudy
▶Enzalutamidedecreases the concentration ofhaloperidol.
Adjust dose.oStudy
▶Enzalutamideis predicted to decrease the exposure to
ibrutinib. Avoid or adjustibrutinibdose.rStudy
▶Enzalutamideis predicted to decrease the exposure to
idelalisib. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
imatinib. Avoid.oStudy
▶Enzalutamideis predicted to decrease the exposure to
irinotecan. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
ivabradine. Adjust dose.oTheoretical
▶Enzalutamideis predicted to moderately to markedly decrease
the exposure toivacaftor. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
ixazomib. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
lapatinib. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
linagliptin.oStudy
▶Enzalutamideis predicted to decrease the exposure to
lomitapide. Monitor and adjust dose.oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
lurasidone. Avoid.oStudy
▶Enzalutamideis predicted to decrease the exposure to
macitentan. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
maraviroc. Adjust dose.rStudy
▶Enzalutamideis predicted to decrease the exposure to
midazolam. Monitor and adjust dose.oStudy
▶Enzalutamideis predicted to decrease the exposure to
midostaurin. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
mirtazapine. Adjust dose.oStudy
▶Enzalutamideis predicted to decrease the exposure to
montelukast.nStudy
▶Enzalutamideis predicted to markedly decrease the exposure
tonaloxegol. Avoid.oStudy
▶Enzalutamideis predicted to slightly decrease the exposure to
nateglinide.nStudy
▶Enzalutamideis predicted to decrease the exposure to
netupitant. Avoid.rStudy
▶Enzalutamideis predicted to moderately decrease the
exposure tonilotinib. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
nitisinone. Adjust dose.oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
olaparib. Avoid.oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
ondansetron.oStudy
▶Enzalutamideis predicted to decrease the exposure toopioids
(alfentanil, fentanyl).oStudy
▶Enzalutamideis predicted to decrease the exposure toopioids
(buprenorphine). Monitor and adjust dose.oTheoretical
▶Enzalutamidedecreases the exposure toopioids(methadone).
Monitor and adjust dose.rStudy
▶Enzalutamideis predicted to decrease the exposure toopioids
(oxycodone). Monitor and adjust dose.oStudy
▶Enzalutamideis predicted to moderately decrease the
exposure toosimertinib. Avoid.oStudy
▶Enzalutamideis predicted to decrease the exposure to
palbociclib. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
paliperidone. Monitor and adjust dose.rStudyBNFC 2018 – 2019 Enzalutamide—Enzalutamide 917
Interactions|Appendix 1A1