▶Mitotaneis predicted to markedly decrease the exposure to
aprepitant. Avoid.oStudy
▶Mitotaneis predicted to moderately decrease the exposure to
aripiprazole. Adjustaripiprazoledose,p. 249.oStudy
▶Mitotaneis predicted to decrease the exposure toaxitinib.
Avoid or adjust dose.oStudy→Also seeTABLE 15p. 850
▶Mitotanedecreases the exposure tobedaquiline. Avoid.r
Study
▶Mitotaneslightly decreases the exposure tobortezomib. Avoid.
rStudy→Also seeTABLE 15p. 850
▶Mitotaneaffects the exposure tobosentan. Avoid.rStudy
▶Mitotaneis predicted to very markedly decrease the exposure
tobosutinib. Avoid.rStudy→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure tobuspirone.
Use with caution and adjust dose.rStudy
▶Mitotanemoderately decreases the exposure tocabozantinib.
Avoid.oStudy→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure tocalcium
channel blockers(amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nimodipine). Monitor and adjust
dose.oStudy
▶Mitotaneis predicted to decrease the exposure tocannabis
extract. Avoid.rTheoretical
▶Mitotaneis predicted to decrease the exposure toceritinib.
Avoid.rStudy→Also seeTABLE 15p. 850
▶Mitotanedecreases the concentration ofciclosporin.r
Study
▶Mitotaneis predicted to alter the effects ofcilostazol.o
Theoretical
▶Mitotaneis predicted to decrease the exposure tocinacalcet.
Monitor and adjust dose.oStudy
▶Mitotanedecreases the exposure toclomethiazole. Monitor
and adjust dose.oStudy
▶Mitotaneis predicted to decrease the exposure tocobicistat.
Avoid.rTheoretical
▶Mitotaneis predicted to decrease the exposure tocobimetinib.
Avoid.rTheoretical
▶Mitotaneis predicted to decrease the exposure to
corticosteroids(budesonide, deflazacort, dexamethasone,
fludrocortisone, hydrocortisone, methylprednisolone,
prednisolone, prednisone, triamcinolone). Monitor and adjust
dose.oStudy
▶Mitotaneis predicted to decrease the exposure to
corticosteroids(fluticasone).qTheoretical
▶Mitotaneis predicted to markedly decrease the exposure to
crizotinib. Avoid.rStudy→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure todabrafenib.
Avoid.oTheoretical→Also seeTABLE 15p. 850
▶Mitotaneis predicted to moderately decrease the exposure to
daclatasvir. Avoid.rStudy
▶Mitotaneis predicted to decrease the exposure todarifenacin.
oTheoretical
▶Mitotaneis predicted to markedly decrease the exposure to
dasatinib. Avoid.rStudy→Also seeTABLE 15p. 850
▶Mitotaneis predicted to slightly decrease the exposure to
delamanid. Avoid.oStudy
▶Mitotanedecreases the exposure todolutegravir. Adjust dose.
rStudy
▶Mitotaneis predicted to decrease the exposure toelbasvir.
Avoid.rStudy
▶Mitotaneis predicted to decrease the exposure toeliglustat.
Avoid.rStudy
▶Mitotaneis predicted to decrease the concentration of
elvitegravir. Avoid.rTheoretical
▶Mitotaneis predicted to decrease the effects ofergotamine.
oTheoretical
▶Mitotaneis predicted to decrease the exposure toerlotinib.
Avoid or adjusterlotinibdose.rStudy
▶Mitotaneis predicted to decrease the exposure toetravirine.
Avoid.rTheoretical
▶Mitotaneis predicted to decrease the concentration of
everolimus. Avoid or adjust dose.rStudy→Also see
TABLE 15p. 850
▶Mitotanemoderately decreases the exposure toexemestane.
oStudy
▶Mitotaneis predicted to decrease the exposure tofesoterodine.
Avoid.oStudy
▶Mitotaneis predicted to decrease the exposure tofingolimod.
oStudy
▶Mitotaneis predicted to decrease the exposure to
fosaprepitant. Avoid.oTheoretical
▶Mitotaneis predicted to decrease the exposure togefitinib.
Avoid.rStudy→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure tograzoprevir.
Avoid.rStudy
▶Mitotaneis predicted to decrease the concentration of
guanfacine. Adjustguanfacinedose,p. 231.oStudy
▶Mitotanedecreases the concentration ofhaloperidol. Adjust
dose.oStudy
▶Mitotaneis predicted to decrease the exposure toibrutinib.
Avoid or adjustibrutinibdose.rStudy→Also seeTABLE 15
p. 850
▶Mitotaneis predicted to decrease the exposure toidelalisib.
Avoid.rStudy→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure toimatinib.
Avoid.oStudy→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure toirinotecan.
Avoid.rStudy→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure toivabradine.
Adjust dose.oTheoretical
▶Mitotaneis predicted to moderately to markedly decrease the
exposure toivacaftor. Avoid.rStudy
▶Mitotaneis predicted to decrease the exposure toixazomib.
Avoid.rStudy
▶Mitotaneis predicted to decrease the exposure tolapatinib.
Avoid.rStudy
▶Mitotaneis predicted to decrease the exposure tolinagliptin.
oStudy
▶Mitotaneis predicted to decrease the exposure tolomitapide.
Monitor and adjust dose.oTheoretical
▶Mitotaneis predicted to decrease the exposure tolurasidone.
Avoid.oStudy
▶Mitotaneis predicted to decrease the exposure tomacitentan.
Avoid.rStudy
▶Mitotaneis predicted to decrease the exposure tomaraviroc.
Adjust dose.rStudy
▶Mitotaneis predicted to decrease the exposure tomidazolam.
Monitor and adjust dose.oStudy
▶Mitotaneis predicted to decrease the exposure tomidostaurin.
Avoid.rStudy
▶Mitotaneis predicted to decrease the exposure tomirtazapine.
Adjust dose.oStudy
▶Mitotaneis predicted to decrease the exposure tomontelukast.
nStudy
▶Mitotaneis predicted to markedly decrease the exposure to
naloxegol. Avoid.oStudy
▶Mitotaneis predicted to slightly decrease the exposure to
nateglinide.nStudy
▶Mitotaneis predicted to decrease the exposure tonetupitant.
Avoid.rStudy
▶Mitotaneis predicted to moderately decrease the exposure to
nilotinib. Avoid.rStudy→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure tonitisinone.
Adjust dose.oTheoretical
▶Mitotaneis predicted to decrease the exposure toolaparib.
Avoid.oTheoretical→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure toondansetron.
oStudy
▶Mitotaneis predicted to decrease the exposure toopioids
(alfentanil, fentanyl).oStudy
▶Mitotaneis predicted to decrease the exposure toopioids
(buprenorphine). Monitor and adjust dose.oTheoretical
▶Mitotanedecreases the exposure toopioids(methadone).
Monitor and adjust dose.rStudy
▶Mitotaneis predicted to decrease the exposure toopioids
(oxycodone). Monitor and adjust dose.oStudy
▶Mitotaneis predicted to moderately decrease the exposure to
osimertinib. Avoid.oStudy
▶Mitotaneis predicted to decrease the exposure topalbociclib.
Avoid.rStudyBNFC 2018 – 2019 Mitotane—Mitotane 955
Interactions|Appendix 1A1