▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure toolaparib. Avoid potent
inhibitors of CYP3A4 or adjustolaparibdose.oStudy
▶Aprepitantis predicted to increase the exposure toolaparib.
Avoid moderate inhibitors of CYP3A4 or adjustolaparibdose.
oTheoretical
▶Bosentanis predicted to decrease the exposure toolaparib.
Avoid.oTheoretical
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure toolaparib. Avoid moderate inhibitors
of CYP3A4 or adjustolaparibdose.oTheoretical
▶Cobicistatis predicted to increase the exposure toolaparib.
Avoid potent inhibitors of CYP3A4 or adjustolaparibdose.
oStudy
▶Crizotinibis predicted to increase the exposure toolaparib.
Avoid moderate inhibitors of CYP3A4 or adjustolaparibdose.
oTheoretical→Also seeTABLE 15p. 850
▶Efavirenzis predicted to decrease the exposure toolaparib.
Avoid.oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
olaparib. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
olaparib. Avoid.oTheoretical
▶HIV-protease inhibitorsare predicted to increase the exposure
toolaparib. Avoid potent inhibitors of CYP3A4 or adjust
olaparibdose.oStudy
▶Idelalisibis predicted to increase the exposure toolaparib.
Avoid potent inhibitors of CYP3A4 or adjustolaparibdose.
oStudy→Also seeTABLE 15p. 850
▶Imatinibis predicted to increase the exposure toolaparib.
Avoid moderate inhibitors of CYP3A4 or adjustolaparibdose.
oTheoretical→Also seeTABLE 15p. 850
▶Macrolides(clarithromycin)are predicted to increase the
exposure toolaparib. Avoid potent inhibitors of CYP3A4 or
adjustolaparibdose.oStudy
▶Macrolides(erythromycin)are predicted to increase the
exposure toolaparib. Avoid moderate inhibitors of CYP3A4 or
adjustolaparibdose.oTheoretical
▶Mitotaneis predicted to decrease the exposure toolaparib.
Avoid.oTheoretical→Also seeTABLE 15p. 850
▶Netupitantis predicted to increase the exposure toolaparib.
Avoid moderate inhibitors of CYP3A4 or adjustolaparibdose.
oTheoretical
▶Nevirapineis predicted to decrease the exposure toolaparib.
Avoid.oTheoretical
▶Nilotinibis predicted to increase the exposure toolaparib.
Avoid moderate inhibitors of CYP3A4 or adjustolaparibdose.
oTheoretical→Also seeTABLE 15p. 850
▶Rifampicinis predicted to decrease the exposure toolaparib.
Avoid.oTheoretical
▶St John’s Wortis predicted to decrease the exposure to
olaparib. Avoid.oTheoretical
Olaratumab→see monoclonal antibodies
Olmesartan→see angiotensin-II receptor antagonists
Olodaterol→see beta 2 agonists
Olsalazine→seeTABLE 15p. 850 (myelosuppression)
Ombitasvir
▶Antiepileptics(carbamazepine)are predicted to decrease the
exposure toombitasvir. Avoid.rTheoretical
▶Rifampicinis predicted to decrease the exposure toombitasvir.
Avoid.rTheoretical
▶St John’s Wortis predicted to decrease the exposure to
ombitasvir. Avoid.rTheoretical
Omega-3-acid ethyl esters→seeTABLE 3p. 847 (anticoagulant
effects)
Omeprazole→see proton pump inhibitors
Ondansetron→seeTABLE 13p. 850 (serotonin syndrome),TABLE 9
p. 849 (QT-interval prolongation)
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toondansetron.oStudy
▶Dopamine receptor agonists(apomorphine)increase the risk of
severe hypotension when given withondansetron. Avoid.
rStudy→Also seeTABLE 9p. 849
▶Enzalutamideis predicted to decrease the exposure to
ondansetron.oStudy
▶Mitotaneis predicted to decrease the exposure toondansetron.
oStudy
▶Rifampicinis predicted to decrease the exposure to
ondansetron.oStudy
Opicapone
▶Opicaponeincreases the exposure tolevodopa. Adjust dose.
oStudy
▶Opicaponeis predicted to increase the exposure toloperamide.
Avoid.oStudy
▶Opicaponeis predicted to increase the risk of elevated blood
pressure when given withmoclobemide. Avoid.r
Theoretical
▶Opicaponeis predicted to increase the risk of elevated blood
pressure when given withmonoamine-oxidase A and B
inhibitors, irreversible. Avoid.rTheoretical
▶Opicaponeis predicted to increase the exposure to
montelukast. Avoid.oStudy
▶Opicaponeis predicted to increase the exposure to
pioglitazone. Avoid.oStudy
▶Opicaponeis predicted to increase the exposure torepaglinide.
Avoid.oStudy
▶Opicaponeis predicted to increase the risk of cardiovascular
side-effects when given withsympathomimetics, inotropic.
rTheoretical
▶Opicaponeis predicted to increase the risk of cardiovascular
side-effects when given withsympathomimetics, vasoconstrictor
(adrenaline/epinephrine, noradrenaline/norepinephrine).
rTheoretical
Opioids→seeTABLE 6p. 848 (bradycardia),TABLE 13p. 850 (serotonin
syndrome),TABLE 9p. 849 (QT-interval prolongation),TABLE 11p. 849
(CNS depressant effects)
alfentanil.buprenorphine.codeine.diamorphine.dihydrocodeine
.diphenoxylate.dipipanone.fentanyl.hydromorphone.
meptazinol.methadone.morphine.oxycodone.papaveretum.
pentazocine.pethidine.remifentanil.sufentanil.tapentadol.
tramadol..
▶Alcohol (beverage)causes rapid release ofopioids
(hydromorphone, morphine)(from extended-release
preparations). Avoid.rStudy→Also seeTABLE 11p. 849
▶Antiarrhythmics(amiodarone)are predicted to increase the
concentration offentanyl.oTheoretical→Also see
TABLE 6p. 848
▶Antiarrhythmics(dronedarone)are predicted to increase the
exposure toopioids(alfentanil, buprenorphine, fentanyl,
oxycodone). Monitor and adjust dose.oStudy
▶Antiarrhythmics(dronedarone)are predicted to increase the
exposure toopioids(methadone, sufentanil).o
Theoretical→Also seeTABLE 9p. 849
▶Antiepileptics(carbamazepine)decrease the concentration of
tramadol. Adjust dose.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tobuprenorphine. Monitor and adjust dose.o
Theoretical→Also seeTABLE 11p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)decrease the exposure tomethadone.
Monitor and adjust dose.rStudy→Also seeTABLE 11p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tooxycodone. Monitor and adjust dose.oStudy→Also
seeTABLE 11p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toopioids(alfentanil, fentanyl).oStudy→Also see
TABLE 11p. 849
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure tomethadone. Adjust dose.
rTheoretical→Also seeTABLE 9p. 849
▶Antifungals, azoles(miconazole)are predicted to increase the
exposure toalfentanil. Use with caution and adjust dose.
oTheoretical
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure toopioids(alfentanil,BNFC 2018 – 2019 Olaparib—Opioids 967
Interactions|Appendix 1A1