Before you move on, assess your understanding of the material with these questions.
For each of the derivatives below, list the nucleophile used to form the derivative in an
acyl substitution reaction and the name of the cyclic form of that functional group.
Carboxylic Acid Derivative Formed by Reaction with: Name of Cyclic Form:
Amide
Ester
Anhydride
1.
Briefly describe the mechanism of nucleophilic acyl substitution reactions.
2.
Can carboxylic acids be reduced by sodium borohydride? Yes or No
3.
Under what conditions will a carboxylic acid spontaneously decarboxylate?
4.
